Gene Symbol: LEU1
Description: 3-isopropylmalate dehydratase LEU1
Alias: 3-isopropylmalate dehydratase LEU1
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Ranish J, Hahn S, Lu Y, Yi E, Li X, Eng J, et al. Identification of TFB5, a new component of general transcription and DNA repair factor IIH. Nat Genet. 2004;36:707-13 pubmed
    ..The identification of a new, evolutionarily conserved, core TFIIH subunit is essential for our understanding of TFIIH function in transcription, DNA repair and human disease. ..
  2. Ano A, Suehiro D, Cha aim K, Aritomi K, Phonimdaeng P, Nontaso N, et al. Combinatorial gene overexpression and recessive mutant gene introduction in sake yeast. Biosci Biotechnol Biochem. 2009;73:633-40 pubmed
    ..Moreover, none of these sake strains had extraneous sequences, and they are thus suitable for use in commercial applications. ..
  3. Bedekovics T, Li H, Gajdos G, Isaya G. Leucine biosynthesis regulates cytoplasmic iron-sulfur enzyme biogenesis in an Atm1p-independent manner. J Biol Chem. 2011;286:40878-88 pubmed publisher
    ..Enzymatic blocks in the pathway (i.e. leu1? or leu2? gene deletion mutations) induced post-transcriptional up-regulation of core components of mitochondrial ..
  4. Ryan E, Tracy J, Kohlhaw G. Subcellular localization of the leucine biosynthetic enzymes in yeast. J Bacteriol. 1973;116:222-5 pubmed
  5. Satyanarayana T, Umbarger H, Lindegren G. Biosynthesis of branched-chain amino acids in yeast: correlation of biochemical blocks and genetic lesions in leucine auxotrophs. J Bacteriol. 1968;96:2012-7 pubmed
    ..The results with the mutants provide strong evidence that the pathway for leucine biosynthesis proposed by Strassman and his colleagues is the sole significant pathway in yeast. ..
  6. Hsu Y, Schimmel P. Yeast LEU1. Repression of mRNA levels by leucine and relationship of 5'-noncoding region to that of LEU2. J Biol Chem. 1984;259:3714-9 pubmed
    Yeast LEU1 encodes the second enzyme in leucine biosynthesis. A 3.5-kilobase pair (kb) yeast genomic DNA fragment which complements a leu1 auxotroph was isolated by yeast transformation...
  7. Wohlschlegel J, Johnson E, Reed S, Yates J. Global analysis of protein sumoylation in Saccharomyces cerevisiae. J Biol Chem. 2004;279:45662-8 pubmed
    ..Additionally, our global analysis has revealed a number of interesting biological patterns in the list of SUMO targets including a clustering of sumoylation targets within macromolecular complexes. ..
  8. Gao Q, Madian A, Liu X, Adamec J, Regnier F. Coupling protein complex analysis to peptide based proteomics. J Chromatogr A. 2010;1217:7661-8 pubmed publisher