Gene Symbol: KRE9
Species: Saccharomyces cerevisiae S288c
Vink E, Vossen J, Ram A, van den Ende H, Brekelmans S, de Nobel H, et al
. The protein kinase Kic1 affects 1,6-beta-glucan levels in the cell wall of Saccharomyces cerevisiae. Microbiology. 2002;148:4035-48 pubmed
..It is proposed that Kic1 affects cell wall construction in multiple ways and in particular in regulating 1,6-beta-glucan levels in the wall. ..
Chavan M, Suzuki T, Rekowicz M, Lennarz W. Genetic, biochemical, and morphological evidence for the involvement of N-glycosylation in biosynthesis of the cell wall beta1,6-glucan of Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 2003;100:15381-6 pubmed
..Using this screen, we were surprised to identify two KRE genes (KRE5 and KRE9) that are involved in the biosynthesis of the cell wall beta1,6-glucan...
Brown J, North S, Bussey H. SKN7, a yeast multicopy suppressor of a mutation affecting cell wall beta-glucan assembly, encodes a product with domains homologous to prokaryotic two-component regulators and to heat shock transcription factors. J Bacteriol. 1993;175:6908-15 pubmed
A search for genes which, at elevated copy number, could suppress the growth defect in a strain disrupted at the KRE9 locus has identified the SKN7 gene...
Ketela T, Green R, Bussey H. Saccharomyces cerevisiae mid2p is a potential cell wall stress sensor and upstream activator of the PKC1-MPK1 cell integrity pathway. J Bacteriol. 1999;181:3330-40 pubmed
..In addition, we have identified an open reading frame, MTL1, which encodes a protein with both structural and functional similarity to Mid2p. ..
Brown J, Bussey H, Stewart R. Yeast Skn7p functions in a eukaryotic two-component regulatory pathway. EMBO J. 1994;13:5186-94 pubmed
..We present evidence suggesting that Skn7p serves as a transcription factor in such a signaling pathway. ..
Dijkgraaf G, Brown J, Bussey H. The KNH1 gene of Saccharomyces cerevisiae is a functional homolog of KRE9. Yeast. 1996;12:683-92 pubmed
..The product encoded by the KNH1 gene, Knhlp, shares 46% overall identity with Kre9p, a protein required for cell surface beta 1,6-glucan synthesis...
Kaeberlein M, Guarente L. Saccharomyces cerevisiae MPT5 and SSD1 function in parallel pathways to promote cell wall integrity. Genetics. 2002;160:83-95 pubmed
..This work also provides evidence that post-transcriptional regulation is likely to be important both for maintaining cell integrity and for promoting longevity. ..
Brown J, Bussey H. The yeast KRE9 gene encodes an O glycoprotein involved in cell surface beta-glucan assembly. Mol Cell Biol. 1993;13:6346-56 pubmed
..Antibodies were generated against Kre9p and detected an O glycoprotein of approximately 55 to 60 kDa found in the extracellular medium of a strain ..