KIP2

Summary

Gene Symbol: KIP2
Description: Kip2p
Alias: Kip2p
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Cottingham F, Hoyt M. Mitotic spindle positioning in Saccharomyces cerevisiae is accomplished by antagonistically acting microtubule motor proteins. J Cell Biol. 1997;138:1041-53 pubmed
    ..defects exhibited by dyn1 kip3 cells are caused, to a large extent, by the actions of kinesin- related Kip2p. Microtubules in kip2Delta cells were shorter and more sensitive to benomyl than wild-type, in contrast to the ..
  2. Markus S, Lee W. Regulated offloading of cytoplasmic dynein from microtubule plus ends to the cortex. Dev Cell. 2011;20:639-51 pubmed publisher
    ..These findings provide direct support for an active microtubule-mediated delivery process that appears to be regulated by a conserved masking/unmasking mechanism. ..
  3. Caudron F, Andrieux A, Job D, Boscheron C. A new role for kinesin-directed transport of Bik1p (CLIP-170) in Saccharomyces cerevisiae. J Cell Sci. 2008;121:1506-13 pubmed publisher
    ..However, in yeast, Bik1p travels towards plus ends as a cargo of the plus-end-directed kinesin Kip2p. Additionally, Kip2p behaves as a plus-end-tracking protein; hence, it has been proposed that Bik1p might track ..
  4. Miller R, Heller K, Frisén L, Wallack D, Loayza D, Gammie A, et al. The kinesin-related proteins, Kip2p and Kip3p, function differently in nuclear migration in yeast. Mol Biol Cell. 1998;9:2051-68 pubmed
    The roles of two kinesin-related proteins, Kip2p and Kip3p, in microtubule function and nuclear migration were investigated...
  5. Carvalho P, Gupta M, Hoyt M, Pellman D. Cell cycle control of kinesin-mediated transport of Bik1 (CLIP-170) regulates microtubule stability and dynein activation. Dev Cell. 2004;6:815-29 pubmed
    ..Bik1 forms a complex with the kinesin Kip2. Fluorescently labeled Bik1 and Kip2 comigrate along individual microtubules...
  6. Farkasovsky M, Küntzel H. Cortical Num1p interacts with the dynein intermediate chain Pac11p and cytoplasmic microtubules in budding yeast. J Cell Biol. 2001;152:251-62 pubmed
    ..In addition, Num1p may transiently cooperate with an associated Bni1p-Kar9p complex at the bud tip of early anaphase cells. ..
  7. Hoepfner D, Schaerer F, Brachat A, Wach A, Philippsen P. Reorientation of mispositioned spindles in short astral microtubule mutant spc72Delta is dependent on spindle pole body outer plaque and Kar3 motor protein. Mol Biol Cell. 2002;13:1366-80 pubmed
    ..that reorientation was dependent on the SPB outer plaque and the astral microtubule motor function of Kar3 but not Kip2/Kip3/Dhc1, or the cortex components Kar9/Num1...
  8. Straight A, Sedat J, Murray A. Time-lapse microscopy reveals unique roles for kinesins during anaphase in budding yeast. J Cell Biol. 1998;143:687-94 pubmed
    ..The kip3Delta and kip1Delta mutants affect the duration of anaphase, but cin8Delta does not. ..
  9. Maekawa H, Usui T, Knop M, Schiebel E. Yeast Cdk1 translocates to the plus end of cytoplasmic microtubules to regulate bud cortex interactions. EMBO J. 2003;22:438-49 pubmed
    ..This movement is dependent upon the microtubule motor protein Kip2. Cdc28 activity is required to concentrate Kar9 at the plus end of CMs and hence to establish contacts with the bud ..

More Information

Publications17

  1. Meednu N, Hoops H, D Silva S, Pogorzala L, Wood S, Farkas D, et al. The spindle positioning protein Kar9p interacts with the sumoylation machinery in Saccharomyces cerevisiae. Genetics. 2008;180:2033-55 pubmed publisher
    ..We propose a model in which sumoylation regulates spindle positioning by restricting Kar9p to one SPB. These findings raise the possibility that sumoylation could regulate other microtubule-dependent processes. ..
  2. Hibbel A, Bogdanova A, Mahamdeh M, Jannasch A, Storch M, Schäffer E, et al. Kinesin Kip2 enhances microtubule growth in vitro through length-dependent feedback on polymerization and catastrophe. elife. 2015;4: pubmed publisher
    ..Here, we report that the budding yeast kinesin Kip2 is a microtubule polymerase and catastrophe inhibitor in vitro that uses its processive motor activity as part of a ..
  3. Roberts A, Goodman B, Reck Peterson S. Reconstitution of dynein transport to the microtubule plus end by kinesin. elife. 2014;3:e02641 pubmed publisher
    ..We find that two proteins-homologs of Lis1 and Clip170-are sufficient to couple dynein to Kip2, a plus-end-directed kinesin...
  4. Cuschieri L, Miller R, Vogel J. Gamma-tubulin is required for proper recruitment and assembly of Kar9-Bim1 complexes in budding yeast. Mol Biol Cell. 2006;17:4420-34 pubmed
    ..We propose that SPBs, via the tail of Tub4, promote the assembly of functional +TIP complexes before their deployment to microtubule +ends. ..
  5. Nelson S, Cooper J. A novel pathway that coordinates mitotic exit with spindle position. Mol Biol Cell. 2007;18:3440-50 pubmed
    ..Each component of this pathway is required for the spindle position checkpoint to delay mitotic exit until the spindle is positioned correctly. ..
  6. Markus S, Kalutkiewicz K, Lee W. She1-mediated inhibition of dynein motility along astral microtubules promotes polarized spindle movements. Curr Biol. 2012;22:2221-30 pubmed publisher
    ..She1 has no effect on the motility of either Kip2, a kinesin that utilizes the same microtubule track as dynein, or human kinesin-1, demonstrating the specificity of ..
  7. Drechsler H, Tan A, Liakopoulos D. Yeast GSK-3 kinase regulates astral microtubule function through phosphorylation of the microtubule-stabilizing kinesin Kip2. J Cell Sci. 2015;128:3910-21 pubmed publisher
    The S. cerevisiae kinesin Kip2 stabilises astral microtubules (MTs) and facilitates spindle positioning through transport of MT-associated proteins, such as the yeast CLIP-170 homologue Bik1, dynein and the adenomatous-polyposis-coli-..
  8. Winsor B, Schiebel E. Review: an overview of the Saccharomyces cerevisiae microtubule and microfilament cytoskeleton. Yeast. 1997;13:399-434 pubmed