Gene Symbol: KGD2
Description: alpha-ketoglutarate dehydrogenase KGD2
Alias: alpha-ketoglutarate dehydrogenase KGD2
Species: Saccharomyces cerevisiae S288c
Repetto B, Tzagoloff A. In vivo assembly of yeast mitochondrial alpha-ketoglutarate dehydrogenase complex. Mol Cell Biol. 1991;11:3931-9 pubmed
..studied in wild-type Saccharomyces cerevisiae and in respiratory-deficient strains (pet) with mutations in KGD1 and KGD2, the structural genes for alpha-ketoglutarate dehydrogenase (KE1) and dihydrolipoyl transsuccinylase (KE2) ..
Repetto B, Tzagoloff A. Structure and regulation of KGD2, the structural gene for yeast dihydrolipoyl transsuccinylase. Mol Cell Biol. 1990;10:4221-32 pubmed
..The nuclear gene KGD2, coding for yeast KE2, was cloned by transformation of E250/U6, a G104 mutant, with a yeast genomic library...
Kaufman B, Newman S, Hallberg R, Slaughter C, Perlman P, Butow R. In organello formaldehyde crosslinking of proteins to mtDNA: identification of bifunctional proteins. Proc Natl Acad Sci U S A. 2000;97:7772-7 pubmed
..These data identify bifunctional proteins that participate in the stability of rho(+) mtDNA. ..
Przybyla Zawislak B, Gadde D, Ducharme K, McCammon M. Genetic and biochemical interactions involving tricarboxylic acid cycle (TCA) function using a collection of mutants defective in all TCA cycle genes. Genetics. 1999;152:153-66 pubmed
..These results provide genetic evidence that NAD-IDH plays a unique role in TCA cycle function. ..
Chen X, Wang X, Kaufman B, Butow R. Aconitase couples metabolic regulation to mitochondrial DNA maintenance. Science. 2005;307:714-7 pubmed
..When constitutively expressed, Aco1p can replace the mtDNA packaging function of the high-mobility-group protein Abf2p. Thus, Aco1p may integrate metabolic signals and mtDNA maintenance. ..
Sato H, Tachifuji A, Tamura M, Miyakawa I. Identification of the YMN-1 antigen protein and biochemical analyses of protein components in the mitochondrial nucleoid fraction of the yeast Saccharomyces cerevisiae. Protoplasma. 2002;219:51-8 pubmed
..These results suggested that a part of KGDC in the mitochondrial matrix is associated with mt-nucleoids in vivo. ..
Heublein M, Burguillos M, VÃ¶gtle F, Teixeira P, Imhof A, Meisinger C, et al
. The novel component Kgd4 recruits the E3 subunit to the mitochondrial Î±-ketoglutarate dehydrogenase. Mol Biol Cell. 2014;25:3342-9 pubmed publisher
..Our work thus reveals a novel subunit of a key citric acid-cycle enzyme and shows how this large complex is organized. ..