Gene Symbol: KGD1
Description: alpha-ketoglutarate dehydrogenase KGD1
Alias: OGD1, alpha-ketoglutarate dehydrogenase KGD1
Species: Saccharomyces cerevisiae S288c
Repetto B, Tzagoloff A. In vivo assembly of yeast mitochondrial alpha-ketoglutarate dehydrogenase complex. Mol Cell Biol. 1991;11:3931-9 pubmed
..has been studied in wild-type Saccharomyces cerevisiae and in respiratory-deficient strains (pet) with mutations in KGD1 and KGD2, the structural genes for alpha-ketoglutarate dehydrogenase (KE1) and dihydrolipoyl transsuccinylase (KE2) ..
McAlister Henn L, Small W. Molecular genetics of yeast TCA cycle isozymes. Prog Nucleic Acid Res Mol Biol. 1997;57:317-39 pubmed
Sato H, Tachifuji A, Tamura M, Miyakawa I. Identification of the YMN-1 antigen protein and biochemical analyses of protein components in the mitochondrial nucleoid fraction of the yeast Saccharomyces cerevisiae. Protoplasma. 2002;219:51-8 pubmed
..These results suggested that a part of KGDC in the mitochondrial matrix is associated with mt-nucleoids in vivo. ..
Chen X, Wang X, Kaufman B, Butow R. Aconitase couples metabolic regulation to mitochondrial DNA maintenance. Science. 2005;307:714-7 pubmed
..When constitutively expressed, Aco1p can replace the mtDNA packaging function of the high-mobility-group protein Abf2p. Thus, Aco1p may integrate metabolic signals and mtDNA maintenance. ..
Heublein M, Burguillos M, VÃ¶gtle F, Teixeira P, Imhof A, Meisinger C, et al
. The novel component Kgd4 recruits the E3 subunit to the mitochondrial Î±-ketoglutarate dehydrogenase. Mol Biol Cell. 2014;25:3342-9 pubmed publisher
..Our work thus reveals a novel subunit of a key citric acid-cycle enzyme and shows how this large complex is organized. ..
Przybyla Zawislak B, Gadde D, Ducharme K, McCammon M. Genetic and biochemical interactions involving tricarboxylic acid cycle (TCA) function using a collection of mutants defective in all TCA cycle genes. Genetics. 1999;152:153-66 pubmed
..These results provide genetic evidence that NAD-IDH plays a unique role in TCA cycle function. ..
Kucej M, Kucejova B, SUBRAMANIAN R, Chen X, Butow R. Mitochondrial nucleoids undergo remodeling in response to metabolic cues. J Cell Sci. 2008;121:1861-8 pubmed publisher
..A mutant form of Hsp60 that causes mtDNA instability has altered submitochondrial localization, which suggests that nucleoid remodeling is essential for the maintenance of mitochondrial genome...
Johnson R, Prakash L, Prakash S. Pol31 and Pol32 subunits of yeast DNA polymerase ? are also essential subunits of DNA polymerase ?. Proc Natl Acad Sci U S A. 2012;109:12455-60 pubmed publisher
..To distinguish the four-subunit complex from the two-subunit Pol?, we designate the four-subunit enzyme "Pol?-d," where "-d" denotes the Pol31/Pol32 subunits of Pol?. ..
Nishida I, Watanabe D, Takagi H. Putative mitochondrial ?-ketoglutarate-dependent dioxygenase Fmp12 controls utilization of proline as an energy source in Saccharomyces cerevisiae. Microb Cell. 2016;3:522-528 pubmed publisher
..dehydrogenase (PUT2), alanine transaminase (ALT1), and ?-ketoglutarate dehydrogenase subunit (KGD1), abolished the enhanced cell growth in ?fmp12...