Gene Symbol: KDX1
Description: putative protein kinase KDX1
Alias: MLP1
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Watanabe Y, Takaesu G, Hagiwara M, Irie K, Matsumoto K. Characterization of a serum response factor-like protein in Saccharomyces cerevisiae, Rlm1, which has transcriptional activity regulated by the Mpk1 (Slt2) mitogen-activated protein kinase pathway. Mol Cell Biol. 1997;17:2615-23 pubmed
    ..We identified a Mpk1-like protein kinase, Mlp1, as an Rlm1-associated protein by using the yeast two-hybrid system...
  2. Palacios L, Dickinson R, Sacristán Reviriego A, Didmon M, Marin M, Martín H, et al. Distinct docking mechanisms mediate interactions between the Msg5 phosphatase and mating or cell integrity mitogen-activated protein kinases (MAPKs) in Saccharomyces cerevisiae. J Biol Chem. 2011;286:42037-50 pubmed publisher
    ..Here we show that Msg5 interacts not only with Fus3, Kss1, and Slt2 but also with the pseudokinase Slt2 paralog Mlp1. Using yeast two-hybrid and in vitro interaction assays, we have identified distinct regions within the N-terminal ..
  3. Hunter T, Plowman G. The protein kinases of budding yeast: six score and more. Trends Biochem Sci. 1997;22:18-22 pubmed
    ..As a consequence, we now know exactly how many protein kinases are encoded by the yeast genome, a number of considerable interest because of the importance of protein phosphorylation in the control of so many cellular processes. ..
  4. Belli G, Molina M, García Martínez J, Pérez Ortín J, Herrero E. Saccharomyces cerevisiae glutaredoxin 5-deficient cells subjected to continuous oxidizing conditions are affected in the expression of specific sets of genes. J Biol Chem. 2004;279:12386-95 pubmed
    ..One of these is MLP1, which codes for a homologue of the Slt2 kinase...
  5. Kim K, Levin D. Transcriptional reporters for genes activated by cell wall stress through a non-catalytic mechanism involving Mpk1 and SBF. Yeast. 2010;27:541-8 pubmed publisher
    ..In this context, the Mlp1 pseudokinase serves a redundant function with Mpk1...
  6. Chang M, Kang H, Baek I, Kang C, Park Y, Yun C. Kdx1 regulates RCK1 gene expression by interacting with Rlm1 in Saccharomyces cerevisiae. Biochem Biophys Res Commun. 2013;435:350-5 pubmed publisher
    b>Kdx1 is known as a stress-responsive protein...
  7. Onishi M, Ko N, Nishihama R, Pringle J. Distinct roles of Rho1, Cdc42, and Cyk3 in septum formation and abscission during yeast cytokinesis. J Cell Biol. 2013;202:311-29 pubmed publisher
    ..This work suggests a general role for the catalytically inactive transglutaminases of fungi and animals, some of which have previously been implicated in cytokinesis. ..
  8. Sacristán Reviriego A, Madrid M, Cansado J, Martín H, Molina M. A conserved non-canonical docking mechanism regulates the binding of dual specificity phosphatases to cell integrity mitogen-activated protein kinases (MAPKs) in budding and fission yeasts. PLoS ONE. 2014;9:e85390 pubmed publisher
    ..These results provide mechanistic insight into MKP-MAPK interplay and stress the relevance of this conserved non-canonical docking site in the regulation of the CWI pathway in fungi. ..
  9. Jin C, Strich R, Cooper K. Slt2p phosphorylation induces cyclin C nuclear-to-cytoplasmic translocation in response to oxidative stress. Mol Biol Cell. 2014;25:1396-407 pubmed publisher

More Information


  1. Harrison J, Bardes E, Ohya Y, Lew D. A role for the Pkc1p/Mpk1p kinase cascade in the morphogenesis checkpoint. Nat Cell Biol. 2001;3:417-20 pubmed
    ..The G2 delay involves stabilization of Swe1p in response to various actin perturbations, although this alone is insufficient to produce a long G2 delay. ..