Gene Symbol: JSN1
Description: Jsn1p
Alias: PUF1, Jsn1p
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Gerber A, Herschlag D, Brown P. Extensive association of functionally and cytotopically related mRNAs with Puf family RNA-binding proteins in yeast. PLoS Biol. 2004;2:E79 pubmed
  2. Ulbricht R, Olivas W. Puf1p acts in combination with other yeast Puf proteins to control mRNA stability. RNA. 2008;14:246-62 pubmed
  3. Machin N, Lee J, Barnes G. Microtubule stability in budding yeast: characterization and dosage suppression of a benomyl-dependent tubulin mutant. Mol Biol Cell. 1995;6:1241-59 pubmed
    ..One of these genes, JSN1, encodes a protein of 125 kDa that has limited similarity to a number of proteins of unknown function...
  4. Olivas W, Parker R. The Puf3 protein is a transcript-specific regulator of mRNA degradation in yeast. EMBO J. 2000;19:6602-11 pubmed
    ..cerevisae, we analyzed the role of five members of the Puf family present in the yeast genome (referred to as JSN1/PUF1, PUF2, PUF3, PUF4 and MPT5/PUF5)...
  5. Goldstrohm A, Seay D, Hook B, Wickens M. PUF protein-mediated deadenylation is catalyzed by Ccr4p. J Biol Chem. 2007;282:109-14 pubmed
    ..Our data suggest that PUF proteins may enhance mRNA degradation and repress expression by both deadenylation-dependent and -independent mechanisms, using the same Pop2p bridge to recruit a multifunctional Pop2p complex to the mRNA. ..
  6. Machin N, Lee J, Chamany K, Barnes G. Dosage suppressors of a benomyl-dependent tubulin mutant: evidence for a link between microtubule stability and cellular metabolism. Genetics. 1996;144:1363-73 pubmed
  7. Fehrenbacher K, Boldogh I, Pon L. A role for Jsn1p in recruiting the Arp2/3 complex to mitochondria in budding yeast. Mol Biol Cell. 2005;16:5094-102 pubmed
    ..We find that Jsn1p, a member of the PUF family of proteins, facilitates association of Arp2/3 complex to yeast mitochondria...
  8. Cridge A, Castelli L, Smirnova J, Selley J, Rowe W, Hubbard S, et al. Identifying eIF4E-binding protein translationally-controlled transcripts reveals links to mRNAs bound by specific PUF proteins. Nucleic Acids Res. 2010;38:8039-50 pubmed publisher
    ..Thus the combined action of each 4E-BP with specific 3'-UTR-binding proteins mediates mRNA-specific translational control in yeast, showing that this form of translational control is more widely employed than previously thought. ..
  9. Yosefzon Y, Koh Y, Chritton J, Lande A, Leibovich L, Barziv L, et al. Divergent RNA binding specificity of yeast Puf2p. RNA. 2011;17:1479-88 pubmed publisher
    ..This study expands the repertoire of cis elements bound by PUF proteins and suggests new modes by which PUF proteins recognize their mRNA targets. ..

More Information


  1. Russo J, Olivas W. Conditional regulation of Puf1p, Puf4p, and Puf5p activity alters YHB1 mRNA stability for a rapid response to toxic nitric oxide stress in yeast. Mol Biol Cell. 2015;26:1015-29 pubmed publisher
    ..Puf1p and Puf4p can bind target mRNA in inactivating conditions; however, Puf5p binding is reduced. This work demonstrates how multiple Puf proteins coordinately regulate YHB1 mRNA to protect cells from nitric oxide stress. ..