IXR1

Summary

Gene Symbol: IXR1
Description: DNA-binding transcription repressor IXR1
Alias: ORD1, DNA-binding transcription repressor IXR1
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Castro Prego R, Lamas Maceiras M, Soengas P, Carneiro I, González Siso I, Cerdán M. Regulatory factors controlling transcription of Saccharomyces cerevisiae IXR1 by oxygen levels: a model of transcriptional adaptation from aerobiosis to hypoxia implicating ROX1 and IXR1 cross-regulation. Biochem J. 2009;425:235-43 pubmed publisher
    ..However, factors controlling IXR1 expression remained unexplored...
  2. Bourdineaud J, De Sampaïo G, Lauquin G. A Rox1-independent hypoxic pathway in yeast. Antagonistic action of the repressor Ord1 and activator Yap1 for hypoxic expression of the SRP1/TIR1 gene. Mol Microbiol. 2000;38:879-90 pubmed
    ..We have found a new hypoxic pathway involving an antagonistic interaction between the Ixr1/Ord1 repressor and the Yap1 factor, a transcriptional activator involved in oxidative stress response...
  3. Rodríguez Lombardero S, Vizoso Vázquez A, Rodríguez Belmonte E, González Siso M, Cerdán M. SKY1 and IXR1 interactions, their effects on cisplatin and spermine resistance in Saccharomyces cerevisiae. Can J Microbiol. 2012;58:184-8 pubmed publisher
    ..Deletion of the IXR1 gene increases resistance to cisplatin, and deletion of the SKY1 gene increases resistance to cisplatin and ..
  4. McA Nulty M, Lippard S. The HMG-domain protein Ixr1 blocks excision repair of cisplatin-DNA adducts in yeast. Mutat Res. 1996;362:75-86 pubmed
    b>Ixr1 is a yeast HMG-domain protein which binds the major DNA adducts of the antitumor drug cisplatin...
  5. McA Nulty M, Whitehead J, Lippard S. Binding of Ixr1, a yeast HMG-domain protein, to cisplatin-DNA adducts in vitro and in vivo. Biochemistry. 1996;35:6089-99 pubmed
    b>Ixr1 is a yeast HMG-domain protein that binds specifically to DNA adducts formed by the antitumor drug cisplatin. Interruption of the IXR1 gene in yeast desensitizes cells to cisplatin...
  6. Castro Prego R, Lamas Maceiras M, Soengas P, Fernández Leiro R, Carneiro I, Becerra M, et al. Ixr1p regulates oxygen-dependent HEM13 transcription. FEMS Yeast Res. 2010;10:309-21 pubmed publisher
    ..Their interactions with the HEM13 promoter might change in the transition from aerobiosis to hypoxia. ..
  7. Batenchuk C, Tepliakova L, Kaern M. Identification of response-modulated genetic interactions by sensitivity-based epistatic analysis. BMC Genomics. 2010;11:493 pubmed publisher
    ..While the method was developed for growth phenotype, it should apply equally well for other phenotypes, including the expression of fluorescent reporters. ..
  8. Fedorov D, Koval tsova S, Peshekhonov V, Korolev V. [IXR1 and HMO1 genes jointly control the level of spontaneous mutagenesis in yeast Saccharomyces cerevisiae]. Genetika. 2010;46:750-7 pubmed
    The yeast genes IXR1 and HMO1 encode proteins belonging to the family of chromatin nonhistone proteins, which are able to recognize and bind to irregular DNA structures...
  9. Tsaponina O, Barsoum E, Aström S, Chabes A. Ixr1 is required for the expression of the ribonucleotide reductase Rnr1 and maintenance of dNTP pools. PLoS Genet. 2011;7:e1002061 pubmed publisher
    ..It has been shown that the deletion of DUN1 is synthetic lethal with the deletion of IXR1, encoding an HMG-box-containing DNA binding protein, but the reason for this lethality is not known...

More Information

Publications11

  1. Liu J, Barrientos A. Transcriptional regulation of yeast oxidative phosphorylation hypoxic genes by oxidative stress. Antioxid Redox Signal. 2013;19:1916-27 pubmed publisher
    ..Rox1 is a transcriptional repressor of COX5b/CYC7 in normoxia. COX5b is additionally repressed by Ord1. Here, we investigated whether these pathways respond to environmental and mitochondria-generated oxidative stress...
  2. Vizoso Vázquez A, Lamas Maceiras M, Becerra M, González Siso M, Rodríguez Belmonte E, Cerdán M. Ixr1p and the control of the Saccharomyces cerevisiae hypoxic response. Appl Microbiol Biotechnol. 2012;94:173-84 pubmed publisher
    ..Analysis of the transcriptome of the wild-type strain BY4741 and its isogenic derivative ?ixr1, grown in aerobic and hypoxic conditions, reveals differential regulation of genes related not only to the hypoxic ..