Gene Symbol: ITR1
Description: myo-inositol transporter ITR1
Alias: myo-inositol transporter ITR1
Species: Saccharomyces cerevisiae S288c
Nikawa J, Tsukagoshi Y, Yamashita S. Isolation and characterization of two distinct myo-inositol transporter genes of Saccharomyces cerevisiae. J Biol Chem. 1991;266:11184-91 pubmed
..Nagumo, T., and Yamashita, S. (1982) J. Bacteriol. 150, 441-446), we isolated two myo-inositol transporter genes, ITR1 and ITR2, from a yeast gene library...
Miyashita M, Shugyo M, Nikawa J. Mutational analysis and localization of the inositol transporters of Saccharomyces cerevisiae. J Biosci Bioeng. 2003;96:291-7 pubmed
Saccharomyces cerevisiae possesses two inositol transport proteins, Itr1p and Itr2p, encoded by the ITR1 and ITR2 genes, respectively. Itr1p and Itr2p are high and low affinity transporters, respectively...
Yamagami K, Yamamoto T, Sakai S, Mioka T, Sano T, Igarashi Y, et al
. Inositol depletion restores vesicle transport in yeast phospholipid flippase mutants. PLoS ONE. 2015;10:e0120108 pubmed publisher
..transporter Itr1p by endocytosis, we found that flippase mutations were also suppressed by the disruption of ITR1, as well as by depletion of inositol from the culture medium...
Puts C, Lenoir G, Krijgsveld J, Williamson P, Holthuis J. A P4-ATPase protein interaction network reveals a link between aminophospholipid transport and phosphoinositide metabolism. J Proteome Res. 2010;9:833-42 pubmed publisher
..Together, these findings suggest that aminophospholipid transport and phosphoinositide metabolism are interconnected at the Golgi. ..
Tamura Y, Harada Y, Nishikawa S, Yamano K, Kamiya M, Shiota T, et al
. Tam41 is a CDP-diacylglycerol synthase required for cardiolipin biosynthesis in mitochondria. Cell Metab. 2013;17:709-18 pubmed publisher
..The present findings unveil the missing step of the cardiolipin synthesis pathway in mitochondria as well as the flexibile regulation of phospholipid biosynthesis to respond to compromised CDP-DAG synthesis in mitochondria. ..
Johnson C, Kweon H, Sheidy D, Shively C, Mellacheruvu D, Nesvizhskii A, et al
. The yeast Sks1p kinase signaling network regulates pseudohyphal growth and glucose response. PLoS Genet. 2014;10:e1004183 pubmed publisher
..Collectively, these results identify Sks1p as an important regulator of filamentation and glucose signaling, with additional relevance towards understanding stress-responsive signaling in C. albicans. ..