| IPT1Gene Symbol: IPT1 Description: inositolphosphotransferase Alias: KTI6, MIC2, SYR4, inositolphosphotransferase Species: Saccharomyces cerevisiae S288c Dickson R, Nagiec E, Wells G, Nagiec M, Lester R. Synthesis of mannose-(inositol-P)2-ceramide, the major sphingolipid in Saccharomyces cerevisiae, requires the IPT1 (YDR072c) gene. J Biol Chem. 1997;272:29620-5 pubmed ..inositol-P-ceramide (IPC), we show that a homolog (open reading frame YDR072c), termed Ipt1 (inositolphosphotransferase 1) is necessary for synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), the most abundant and complex .. Balguerie A, Bagnat M, Bonneu M, Aigle M, Breton A. Rvs161p and sphingolipids are required for actin repolarization following salt stress. Eukaryot Cell. 2002;1:1021-31 pubmed ..salt sensitivity all occurred in genes required for sphingolipid biosynthesis: FEN1, SUR4, SUR2, SUR1, and IPT1. These suppressors also suppressed act1-1-related salt sensitivity and the defect in actin repolarization of the .. Tomishige N, Noda Y, Adachi H, Shimoi H, Takatsuki A, Yoda K. Mutations that are synthetically lethal with a gas1Delta allele cause defects in the cell wall of Saccharomyces cerevisiae. Mol Genet Genomics. 2003;269:562-73 pubmed ..Furthermore, the genes CSG2 and IPT1 were found to be required for normal growth of gas1Delta cells in the presence of 1 M sorbitol... Zink S, Mehlgarten C, Kitamoto H, Nagase J, Jablonowski D, Dickson R, et al. Mannosyl-diinositolphospho-ceramide, the major yeast plasma membrane sphingolipid, governs toxicity of Kluyveromyces lactis zymocin. Eukaryot Cell. 2005;4:879-89 pubmed ..Here we present an analysis of kti6 mutants, which resist exogenous zymocin but are sensitive to intracellular expression of its inhibitory gamma-toxin .. Thevissen K, Yen W, Carmona Gutierrez D, Idkowiak Baldys J, Aerts A, Francois I, et al. Skn1 and Ipt1 negatively regulate autophagy in Saccharomyces cerevisiae. FEMS Microbiol Lett. 2010;303:163-8 pubmed publisher We demonstrated that a yeast deletion mutant in IPT1 and SKN1, encoding proteins involved in the biosynthesis of mannosyldiinositolphosphoryl ceramides, is characterized by increased autophagy and DNA fragmentation upon nitrogen (N) .. Tani M, Kuge O. Requirement of a specific group of sphingolipid-metabolizing enzyme for growth of yeast Saccharomyces cerevisiae under impaired metabolism of glycerophospholipids. Mol Microbiol. 2010;78:395-413 pubmed ..analysis involving the SAC1 and non-essential sphingolipid-metabolizing enzyme genes revealed that csg1?, csg2?, ipt1? or scs7? causes synthetic lethality with deletion of SAC1... Toume M, Tani M. Change in activity of serine palmitoyltransferase affects sensitivity to syringomycin E in yeast Saccharomyces cerevisiae. FEMS Microbiol Lett. 2014;358:64-71 pubmed publisher ..These results suggested that an increase in sphingolipid biosynthesis caused by a change in the activity of serine palmitoyltransferase causes resistance to syringomycin E. .. De Block J, Szopinska A, Guerriat B, Dodzian J, Villers J, Hochstenbach J, et al. Yeast Pmp3p has an important role in plasma membrane organization. J Cell Sci. 2015;128:3646-59 pubmed publisher ..These genetic interactions, together with lipid binding assays and epifluorescence microscopy, as well as other biochemical experiments, suggest that Pmp3p could be part of a phosphoinositide-regulated stress sensor. .. Katta S, Chen J, Gardner J, Friederichs J, Smith S, Gogol M, et al. Sec66-Dependent Regulation of Yeast Spindle-Pole Body Duplication Through Pom152. Genetics. 2015;201:1479-95 pubmed publisher
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