Gene Symbol: IMP1
Description: endopeptidase catalytic subunit IMP1
Alias: endopeptidase catalytic subunit IMP1
Species: Saccharomyces cerevisiae S288c
Schneider A, Behrens M, Scherer P, Pratje E, Michaelis G, Schatz G. Inner membrane protease I, an enzyme mediating intramitochondrial protein sorting in yeast. EMBO J. 1991;10:247-54 pubmed
..This 'inner membrane protease I' shares several key features with the leader peptidase of Escherichia coli and the signal peptidase of the endoplasmic reticulum. ..
Schneider A, Oppliger W, Jeno P. Purified inner membrane protease I of yeast mitochondria is a heterodimer. J Biol Chem. 1994;269:8635-8 pubmed
..We have previously shown that one of its subunits is a 21.4-kDa integral membrane protein encoded by the nuclear IMP1 gene. We have now purified the active protease approximately 300-fold from yeast mitochondria...
Nunnari J, Fox T, Walter P. A mitochondrial protease with two catalytic subunits of nonoverlapping specificities. Science. 1993;262:1997-2004 pubmed
..Thus, inner membrane protease, and by analogy eukaryotic multisubunit signal peptidases, may have acquired multiple catalytic subunits by gene duplication to broaden their range of substrate specificity. ..
Esser K, Pratje E, Michaelis G. SOM 1, a small new gene required for mitochondrial inner membrane peptidase function in Saccharomyces cerevisiae. Mol Gen Genet. 1996;252:437-45 pubmed
b>IMP1 encodes a subunit of the mitochondrial inner membrane peptidase responsible for the proteolytic processing of cytochrome oxidase subunit 2 (Cox2) and cytochrome b2 (Cytb2)...
Jan P, Esser K, Pratje E, Michaelis G. Som1, a third component of the yeast mitochondrial inner membrane peptidase complex that contains Imp1 and Imp2. Mol Gen Genet. 2000;263:483-91 pubmed
..The peptidase contains two catalytic subunits, Imp1 and Imp2...
Navarro Aviñó J, Bellés J, Serrano R. Yeast inositol mono- and trisphosphate levels are modulated by inositol monophosphatase activity and nutrients. Biochem Biophys Res Commun. 2003;302:41-5 pubmed
Yeast lithium-sensitive inositol monophosphatase (IMPase) is encoded by a non-essential gene pair (IMP1 and IMP2)...
Luo W, Fang H, Green N. Substrate specificity of inner membrane peptidase in yeast mitochondria. Mol Genet Genomics. 2006;275:431-6 pubmed
..These results suggest, surprisingly, G-3-P dehydrogenase has switched from Imp1p in yeast to Imp2p in mammals. ..
Elliott L, Saracco S, Fox T. Multiple roles of the Cox20 chaperone in assembly of Saccharomyces cerevisiae cytochrome c oxidase. Genetics. 2012;190:559-67 pubmed publisher
..Pre-Cox2 leader peptide processing by Imp1 occurs in the absence of Cox20 and i-AAA protease activity, but is greatly reduced in efficiency...
Ieva R, Heißwolf A, Gebert M, Vögtle F, Wollweber F, Mehnert C, et al
. Mitochondrial inner membrane protease promotes assembly of presequence translocase by removing a carboxy-terminal targeting sequence. Nat Commun. 2013;4:2853 pubmed publisher
..Here, we report that the TIM23 complex is altered in mitochondria lacking the IMP subunit Imp1 although none of the TIM23 components contains a bipartite presequence...