IME1

Summary

Gene Symbol: IME1
Description: transcription factor IME1
Alias: transcription factor IME1
Species: Saccharomyces cerevisiae S288c
Products:     IME1

Top Publications

  1. Vidan S, Mitchell A. Stimulation of yeast meiotic gene expression by the glucose-repressible protein kinase Rim15p. Mol Cell Biol. 1997;17:2688-97 pubmed
    ..Deletion of RIM15 causes reduced expression of several early meiotic genes (IME2, SPO13, and HOP1) and of IME1, which specifies an activator of early meiotic genes...
  2. Gerke J, Lorenz K, Cohen B. Genetic interactions between transcription factors cause natural variation in yeast. Science. 2009;323:498-501 pubmed publisher
    ..and vineyard strains is due to allelic variation between four nucleotide changes in three transcription factors: IME1, RME1, and RSF1...
  3. Matsuura A, Treinin M, Mitsuzawa H, Kassir Y, Uno I, Simchen G. The adenylate cyclase/protein kinase cascade regulates entry into meiosis in Saccharomyces cerevisiae through the gene IME1. EMBO J. 1990;9:3225-32 pubmed
    ..The gene IME1 is also involved in starvation control of meiosis...
  4. Mandel S, Robzyk K, Kassir Y. IME1 gene encodes a transcription factor which is required to induce meiosis in Saccharomyces cerevisiae. Dev Genet. 1994;15:139-47 pubmed
    Previous studies have shown that the IME1 gene is required for sporulation and the expression of meiosis specific genes in Saccharomyces cerevisiae...
  5. Rubin Bejerano I, Sagee S, Friedman O, Pnueli L, Kassir Y. The in vivo activity of Ime1, the key transcriptional activator of meiosis-specific genes in Saccharomyces cerevisiae, is inhibited by the cyclic AMP/protein kinase A signal pathway through the glycogen synthase kinase 3-beta homolog Rim11. Mol Cell Biol. 2004;24:6967-79 pubmed
    ..in a medium promoting vegetative growth with acetate as the sole carbon source (SA medium), Rim11 phosphorylates Ime1, the master transcriptional activator required for entry into the meiotic cycle and for the transcription of early ..
  6. Arevalo Rodriguez M, Heitman J. Cyclophilin A is localized to the nucleus and controls meiosis in Saccharomyces cerevisiae. Eukaryot Cell. 2005;4:17-29 pubmed
    ..Our findings reveal a novel nuclear role for cyclophilin A in governing the transcriptional program required for the vegetative to meiotic developmental switch in budding yeast. ..
  7. Malathi K, Xiao Y, Mitchell A. Catalytic roles of yeast GSK3beta/shaggy homolog Rim11p in meiotic activation. Genetics. 1999;153:1145-52 pubmed
    ..Therefore, Ime1p and Rim11p have two genetically separable functions in the sporulation program. However, catalytic activity of Rim11p is required for sporulation in the presence or absence of Ume6p. ..
  8. Colomina N, Gari E, Gallego C, Herrero E, Aldea M. G1 cyclins block the Ime1 pathway to make mitosis and meiosis incompatible in budding yeast. EMBO J. 1999;18:320-9 pubmed
    ..While G1 cyclins play a key role in initiating the mitotic cell cycle, entry into meiosis depends on Ime1, a transcriptional activator regulated by both nutritional and cell-type signals...
  9. Su S, Mitchell A. Identification of functionally related genes that stimulate early meiotic gene expression in yeast. Genetics. 1993;133:67-77 pubmed
    ..We have isolated mutations that cause reduced expression of an ime2-lacZ fusion gene. We found mutations in IME1, a known positive regultor of IME2, and MCK1, a known positive regulator of IME1...

More Information

Publications26

  1. Malathi K, Xiao Y, Mitchell A. Interaction of yeast repressor-activator protein Ume6p with glycogen synthase kinase 3 homolog Rim11p. Mol Cell Biol. 1997;17:7230-6 pubmed
    ..Therefore, interaction between Rim11p and Ume6p, resulting in phosphorylation of Ume6p, is required for Ime1p-Ume6p complex formation. Rim11p, like metazoan GSK3beta, phosphorylates both interacting subunits of a target protein complex. ..
  2. Piccirillo S, Morales R, White M, Smith K, Kapros T, Honigberg S. Cell Differentiation and Spatial Organization in Yeast Colonies: Role of Cell-Wall Integrity Pathway. Genetics. 2015;201:1427-38 pubmed publisher
    ..The relative fraction of the colony apportioned to feeder cells depends on nutrient environment, potentially buffering sexual reproduction against suboptimal environments. ..
  3. Nakazawa N, Abe K, Koshika Y, Iwano K. Cln3 blocks IME1 transcription and the Ime1-Ume6 interaction to cause the sporulation incompetence in a sake yeast, Kyokai no. 7. J Biosci Bioeng. 2010;110:1-7 pubmed publisher
    ..7 (K7), are generally unable to sporulate. In K7 (Saccharomyces cerevisiae) cells, IME1 transcription was not induced under sporulation conditions, and K7 cells partially restored sporulation ability ..
  4. Smith H, Driscoll S, Sia R, Yuan H, Mitchell A. Genetic evidence for transcriptional activation by the yeast IME1 gene product. Genetics. 1993;133:775-84 pubmed
    b>IME1 is required in yeast for meiosis and for expression of IME2 and other early meiotic genes. IME1 is a 360-amino acid polypeptide with central and C-terminal tyrosine-rich regions...
  5. Zhao H, Wang Q, Liu C, Shang Y, Wen F, Wang F, et al. A Role for the Respiratory Chain in Regulating Meiosis Initiation in Saccharomyces cerevisiae. Genetics. 2018;208:1181-1194 pubmed publisher
    ..revealed that respiratory deficiency resulted in the failure of premeiotic DNA replication due to insufficient IME1 expression...
  6. Bowdish K, Yuan H, Mitchell A. Analysis of RIM11, a yeast protein kinase that phosphorylates the meiotic activator IME1. Mol Cell Biol. 1994;14:7909-19 pubmed
    ..Known regulators of early meiotic genes include IME1, which is required for their expression, and SIN3 and UME6, which prevent their expression in nonmeiotic cells...
  7. Inai T, Yukawa M, Tsuchiya E. Interplay between chromatin and trans-acting factors on the IME2 promoter upon induction of the gene at the onset of meiosis. Mol Cell Biol. 2007;27:1254-63 pubmed
    ..IME2 expression in meiosis requires Gcn5/histone acetyltransferase, the transcriptional activator Ime1, and the chromatin remodeler RSC; however, the molecular basis of IME2 activation had not been previously defined...
  8. Koyama H, Nagao T, Inai T, Miyahara K, Hayasida Y, Shirahige K, et al. RSC Nucleosome-remodeling complex plays prominent roles in transcriptional regulation throughout budding yeast gametogenesis. Biosci Biotechnol Biochem. 2004;68:909-19 pubmed
    ..This defect is partially suppressed by the overexpression of either IME1 or IME2...
  9. Guttmann Raviv N, Martin S, Kassir Y. Ime2, a meiosis-specific kinase in yeast, is required for destabilization of its transcriptional activator, Ime1. Mol Cell Biol. 2002;22:2047-56 pubmed
    ..yeast Saccharomyces cerevisiae, entry into meiosis and its successful completion depend on two positive regulators, Ime1 and Ime2...
  10. Mitchell A, Bowdish K. Selection for early meiotic mutants in yeast. Genetics. 1992;131:65-72 pubmed
    ..Entry into meiosis is accompanied by an increase in expression of the IME1 gene; the IME1 product (IME1) then activates IME2 and other meiotic genes...
  11. Beeser A, Cooper T. The dual-specificity protein phosphatase Yvh1p acts upstream of the protein kinase mck1p in promoting spore development in Saccharomyces cerevisiae. J Bacteriol. 1999;181:5219-24 pubmed
    ..We show that yvh1 disruption causes a defect in spore maturation; overexpression of MCK1 or IME1 suppresses this yvh1 phenotype...
  12. Chu S, Herskowitz I. Gametogenesis in yeast is regulated by a transcriptional cascade dependent on Ndt80. Mol Cell. 1998;1:685-96 pubmed
    ..Transcription of NDT80 itself is dependent on Ime1, which activates expression of early sporulation genes...
  13. Hanlon S, Norris D, Vershon A. Depletion of H2A-H2B dimers in Saccharomyces cerevisiae triggers meiotic arrest by reducing IME1 expression and activating the BUB2-dependent branch of the spindle checkpoint. Genetics. 2003;164:1333-44 pubmed
    ..genes and that the meiotic arrest of the hta1-htb1Delta mutant can be partially bypassed by overexpression of IME1. Additionally, deletions of BUB2 or BFA1, components of one branch of the spindle checkpoint pathway, bypass the ..
  14. Yukawa M, Katoh S, Miyakawa T, Tsuchiya E. Nps1/Sth1p, a component of an essential chromatin-remodeling complex of Saccharomyces cerevisiae, is required for the maximal expression of early meiotic genes. Genes Cells. 1999;4:99-110 pubmed
    ..The sporulation defect of nps1-105 was alleviated by the over-expression of either IME1 or IME2. However, over-expression of IME1 did not permit the full expression of IME2, SPO11 and SPO13 in nps1-105...
  15. Strudwick N, Brown M, Parmar V, Schroder M. Ime1 and Ime2 are required for pseudohyphal growth of Saccharomyces cerevisiae on nonfermentable carbon sources. Mol Cell Biol. 2010;30:5514-30 pubmed publisher
    ..Pseudohyphal SK1 cells can exit pseudohyphal growth to complete meiosis. Two stimulators of meiosis, Ime1 and Ime2, are required for pseudohyphal growth of SK1 cells in the presence of nonfermentable carbon sources...
  16. Kahana Edwin S, Stark M, Kassir Y. Multiple MAPK cascades regulate the transcription of IME1, the master transcriptional activator of meiosis in Saccharomyces cerevisiae. PLoS ONE. 2013;8:e78920 pubmed publisher
    ..In Saccharomyces cerevisiae, entry into meiosis depends on multiple signals converging upon IME1, the master transcriptional activator of meiosis...
  17. Rubin Bejerano I, Mandel S, Robzyk K, Kassir Y. Induction of meiosis in Saccharomyces cerevisiae depends on conversion of the transcriptional represssor Ume6 to a positive regulator by its regulated association with the transcriptional activator Ime1. Mol Cell Biol. 1996;16:2518-26 pubmed
    ..genes, as well as the initiation of meiosis, in the budding yeast Saccharomyces cerevisiae depends on IME1. IME1 encodes a transcriptional activator which lacks known DNA binding motifs...