IMA1

Summary

Gene Symbol: IMA1
Description: oligo-1,6-glucosidase IMA1
Alias: oligo-1,6-glucosidase IMA1
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Naumoff D, Naumov G. Discovery of a novel family of alpha-glucosidase IMA genes in yeast Saccharomyces cerevisiae. Dokl Biochem Biophys. 2010;432:114-6 pubmed
  2. Yamamoto K, Miyake H, Kusunoki M, Osaki S. Crystal structures of isomaltase from Saccharomyces cerevisiae and in complex with its competitive inhibitor maltose. FEBS J. 2010;277:4205-14 pubmed publisher
    ..These features of the isomaltase active site pocket prevent isomalto-oligosaccharides from binding to the active site effectively. ..
  3. Deng X, Petitjean M, Teste M, Kooli W, Tranier S, Francois J, et al. Similarities and differences in the biochemical and enzymological properties of the four isomaltases from Saccharomyces cerevisiae. FEBS Open Bio. 2014;4:200-12 pubmed publisher
    ..Altogether, this work illustrates that a gene family encoding proteins with strong sequence similarities can lead to enzyme with notable differences in biochemical and enzymological properties. ..
  4. Brown C, Murray A, Verstrepen K. Rapid expansion and functional divergence of subtelomeric gene families in yeasts. Curr Biol. 2010;20:895-903 pubmed publisher
  5. Teste M, Francois J, Parrou J. Characterization of a new multigene family encoding isomaltases in the yeast Saccharomyces cerevisiae, the IMA family. J Biol Chem. 2010;285:26815-24 pubmed publisher
    ..five genes encodes a protein with alpha-glucosidase activity on isomaltose, and we therefore renamed these genes IMA1 to IMA5 for IsoMAltase...
  6. Yamamoto K, Miyake H, Kusunoki M, Osaki S. Steric hindrance by 2 amino acid residues determines the substrate specificity of isomaltase from Saccharomyces cerevisiae. J Biosci Bioeng. 2011;112:545-50 pubmed publisher
    ..Two isomaltase mutant enzymes - V216T and Q279A - hydrolyzed maltose. Thus, the amino acid residues at these positions may be largely responsible for determining the substrate specificity of ?-glucosidases. ..
  7. Yamamoto K, Nakayama A, Yamamoto Y, Tabata S. Val216 decides the substrate specificity of alpha-glucosidase in Saccharomyces cerevisiae. Eur J Biochem. 2004;271:3414-20 pubmed