Gene Symbol: ILV5
Description: ketol-acid reductoisomerase
Alias: ketol-acid reductoisomerase
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Petersen J, Holmberg S. The ILV5 gene of Saccharomyces cerevisiae is highly expressed. Nucleic Acids Res. 1986;14:9631-51 pubmed
    The nucleotide sequence of the yeast ILV5 gene, which codes for the branched-chain amino acid biosynthesis enzyme acetohydroxyacid reductoisomerase, has been determined...
  2. Zelenaya Troitskaya O, Perlman P, Butow R. An enzyme in yeast mitochondria that catalyzes a step in branched-chain amino acid biosynthesis also functions in mitochondrial DNA stability. EMBO J. 1995;14:3268-76 pubmed
    ..The suppressor is a known gene, ILV5, encoding the mitochondrial protein, acetohydroxy acid reductoisomerase, which catalyzes a step in branched-chain ..
  3. Kaufman B, Newman S, Hallberg R, Slaughter C, Perlman P, Butow R. In organello formaldehyde crosslinking of proteins to mtDNA: identification of bifunctional proteins. Proc Natl Acad Sci U S A. 2000;97:7772-7 pubmed
    ..These data identify bifunctional proteins that participate in the stability of rho(+) mtDNA. ..
  5. Park S, Hanekamp T, Thorsness M, Thorsness P. Yme2p is a mediator of nucleoid structure and number in mitochondria of the yeast Saccharomyces cerevisiae. Curr Genet. 2006;50:173-82 pubmed
    ..The extragenic suppressor, a missense allele of ILV5, encodes an enzyme of the branched-chain amino acid biosynthetic pathway that is also a component of mitochondrial ..
  6. Iacovino M, Granycome C, Sembongi H, Bokori Brown M, Butow R, Holt I, et al. The conserved translocase Tim17 prevents mitochondrial DNA loss. Hum Mol Genet. 2009;18:65-74 pubmed publisher
    ..For example, Ilv5 is required for branched chain amino acid biosynthesis and mtDNA stability...
  7. Chen X, Nielsen K, Borodina I, Kielland Brandt M, Karhumaa K. Increased isobutanol production in Saccharomyces cerevisiae by overexpression of genes in valine metabolism. Biotechnol Biofuels. 2011;4:21 pubmed publisher
    ..16 to 0.97 mg per g glucose by simultaneous overexpression of biosynthetic genes ILV2, ILV3, and ILV5 in valine metabolism in anaerobic fermentation of glucose in mineral medium in S. cerevisiae...
  8. Kingsbury J, Sen N, Cardenas M. Branched-Chain Aminotransferases Control TORC1 Signaling in Saccharomyces cerevisiae. PLoS Genet. 2015;11:e1005714 pubmed publisher
  9. Chen X, Wang X, Kaufman B, Butow R. Aconitase couples metabolic regulation to mitochondrial DNA maintenance. Science. 2005;307:714-7 pubmed
    ..When constitutively expressed, Aco1p can replace the mtDNA packaging function of the high-mobility-group protein Abf2p. Thus, Aco1p may integrate metabolic signals and mtDNA maintenance. ..

More Information


  1. Macierzanka M, Plotka M, Pryputniewicz Drobinska D, Lewandowska A, Lightowlers R, Marszalek J. Maintenance and stabilization of mtDNA can be facilitated by the DNA-binding activity of Ilv5p. Biochim Biophys Acta. 2008;1783:107-17 pubmed
    ..Deletions of ILV5 lead not only to metabolic defects but also to destabilization of mtDNA...
  2. Omura F. Targeting of mitochondrial Saccharomyces cerevisiae Ilv5p to the cytosol and its effect on vicinal diketone formation in brewing. Appl Microbiol Biotechnol. 2008;78:503-13 pubmed publisher
    ..Unlike the case of the wild-type Ilv5p, an additional expression of Ilv5pDelta46 did not alter the quality of the resultant beer in terms of contents of aromatic compounds and organic acids. ..
  3. Chen L, Wang M, Hou J, Liu L, Fu J, Shen Y, et al. Regulation of Saccharomyces cerevisiae MEF1 by Hda1p affects salt resistance of bdf1Δ mutant. FEMS Yeast Res. 2014;14:575-85 pubmed
    ..Among the six genes, over-expression of PDB1, ILV5, or ATP2 partially recovered the salt stress sensitivity of bdf1Δ...