Gene Symbol: ILV5
Description: ketol-acid reductoisomerase
Alias: ketol-acid reductoisomerase
Species: Saccharomyces cerevisiae S288c
Petersen J, Holmberg S. The ILV5 gene of Saccharomyces cerevisiae is highly expressed. Nucleic Acids Res. 1986;14:9631-51 pubmed
The nucleotide sequence of the yeast ILV5 gene, which codes for the branched-chain amino acid biosynthesis enzyme acetohydroxyacid reductoisomerase, has been determined...
Zelenaya Troitskaya O, Perlman P, Butow R. An enzyme in yeast mitochondria that catalyzes a step in branched-chain amino acid biosynthesis also functions in mitochondrial DNA stability. EMBO J. 1995;14:3268-76 pubmed
..The suppressor is a known gene, ILV5, encoding the mitochondrial protein, acetohydroxy acid reductoisomerase, which catalyzes a step in branched-chain ..
Kaufman B, Newman S, Hallberg R, Slaughter C, Perlman P, Butow R. In organello formaldehyde crosslinking of proteins to mtDNA: identification of bifunctional proteins. Proc Natl Acad Sci U S A. 2000;97:7772-7 pubmed
..These data identify bifunctional proteins that participate in the stability of rho(+) mtDNA. ..
Kakar S, Wagner R. GENETIC AND BIOCHEMICAL ANALYSIS OF ISOLEUCINE-VALINE MUTANTS OF YEAST. Genetics. 1964;49:213-22 pubmed
Park S, Hanekamp T, Thorsness M, Thorsness P. Yme2p is a mediator of nucleoid structure and number in mitochondria of the yeast Saccharomyces cerevisiae. Curr Genet. 2006;50:173-82 pubmed
..The extragenic suppressor, a missense allele of ILV5, encodes an enzyme of the branched-chain amino acid biosynthetic pathway that is also a component of mitochondrial ..
Iacovino M, Granycome C, Sembongi H, Bokori Brown M, Butow R, Holt I, et al
. The conserved translocase Tim17 prevents mitochondrial DNA loss. Hum Mol Genet. 2009;18:65-74 pubmed publisher
..For example, Ilv5 is required for branched chain amino acid biosynthesis and mtDNA stability...
Chen X, Nielsen K, Borodina I, Kielland Brandt M, Karhumaa K. Increased isobutanol production in Saccharomyces cerevisiae by overexpression of genes in valine metabolism. Biotechnol Biofuels. 2011;4:21 pubmed publisher
..16 to 0.97 mg per g glucose by simultaneous overexpression of biosynthetic genes ILV2, ILV3, and ILV5 in valine metabolism in anaerobic fermentation of glucose in mineral medium in S. cerevisiae...
Kingsbury J, Sen N, Cardenas M. Branched-Chain Aminotransferases Control TORC1 Signaling in Saccharomyces cerevisiae. PLoS Genet. 2015;11:e1005714 pubmed publisher
Chen X, Wang X, Kaufman B, Butow R. Aconitase couples metabolic regulation to mitochondrial DNA maintenance. Science. 2005;307:714-7 pubmed
..When constitutively expressed, Aco1p can replace the mtDNA packaging function of the high-mobility-group protein Abf2p. Thus, Aco1p may integrate metabolic signals and mtDNA maintenance. ..