Gene Symbol: IFH1
Description: Ifh1p
Alias: Ifh1p
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Cherel I, Thuriaux P. The IFH1 gene product interacts with a fork head protein in Saccharomyces cerevisiae. Yeast. 1995;11:261-70 pubmed
    ..A full deletion of IFH1 is lethal, but growth was restored in a strain deleted for both IFH1 and FHL1. Thus, Ifh1p is essential for growth, but only in the presence of a functional Fhp1p protein...
  2. Munding E, Shiue L, Katzman S, Donohue J, Ares M. Competition between pre-mRNAs for the splicing machinery drives global regulation of splicing. Mol Cell. 2013;51:338-48 pubmed publisher
    ..Downregulation of the RPG-dedicated transcription factor gene IFH1 genetically suppresses two spliceosome mutations, prp11-1 and prp4-1, and globally restores splicing efficiency in ..
  3. Albert B, Knight B, Merwin J, Martin V, Ottoz D, Gloor Y, et al. A Molecular Titration System Coordinates Ribosomal Protein Gene Transcription with Ribosomal RNA Synthesis. Mol Cell. 2016;64:720-733 pubmed publisher
    ..Here we show that an interaction between the RPG transcriptional activator Ifh1 and the rRNA processing factor Utp22 serves to coordinate RPG transcription with that of rRNA...
  4. Singer M, Kahana A, Wolf A, Meisinger L, Peterson S, Goggin C, et al. Identification of high-copy disruptors of telomeric silencing in Saccharomyces cerevisiae. Genetics. 1998;150:613-32 pubmed
    ..component Sir4p, DNA helicase Dna2p, ribosomal protein L32, and two proteins of unknown function, Asf1p and Ifh1p. The collection also included genes that had not previously been identified: DOT1, DOT4, DOT5, DOT6, and TLC1, ..
  5. Kleinschmidt M, Schulz R, Braus G. The yeast CPC2/ASC1 gene is regulated by the transcription factors Fhl1p and Ifh1p. Curr Genet. 2006;49:218-28 pubmed
    ..Increased amounts of the Fhl1p co-regulator Ifh1p induce CPC2 transcription even when ethanol is utilized...
  6. Auld K, Hitchcock A, Doherty H, Frietze S, Huang L, Silver P. The conserved ATPase Get3/Arr4 modulates the activity of membrane-associated proteins in Saccharomyces cerevisiae. Genetics. 2006;174:215-27 pubmed
    ..In combination, our characterization of GET3 genetic and biochemical interactions with NPL4, GET1, and GET2 implicates Get3 in multiple membrane-dependent pathways. ..
  7. Kim E, Kim J, Kim Y, Lee P, Shin D, Kim M, et al. Development of high-throughput phosphorylation profiling method for identification of Ser/Thr kinase specificity. J Pept Sci. 2011;17:392-7 pubmed publisher
    ..On the basis of the result, we identified Ifh1, which is a co-activator for the transcription of ribosomal protein genes, as a novel substrate of Yak1 kinase...
  8. Wade J, Hall D, Struhl K. The transcription factor Ifh1 is a key regulator of yeast ribosomal protein genes. Nature. 2004;432:1054-8 pubmed
    ..Here we show that the transcription factors Fhl1 and Ifh1 associate almost exclusively with RP promoters; association depends on Rap1 and (to a lesser extent) a DNA element ..
  9. Schawalder S, Kabani M, Howald I, Choudhury U, Werner M, Shore D. Growth-regulated recruitment of the essential yeast ribosomal protein gene activator Ifh1. Nature. 2004;432:1058-61 pubmed
    ..8) were shown to bind upstream of many RP genes. Here we show that the essential protein Ifh1 binds to and activates many RP gene promoters under optimal growth conditions in Saccharomyces cerevisiae...

More Information


  1. Martin D, Soulard A, Hall M. TOR regulates ribosomal protein gene expression via PKA and the Forkhead transcription factor FHL1. Cell. 2004;119:969-79 pubmed
    ..transcription via TOR and PKA in yeast involves the Forkhead-like transcription factor FHL1 and the two cofactors IFH1 (a coactivator) and CRF1 (a corepressor)...
  2. Rudra D, Mallick J, Zhao Y, Warner J. Potential interface between ribosomal protein production and pre-rRNA processing. Mol Cell Biol. 2007;27:4815-24 pubmed
    ..by RNA polymerase II, is controlled by the interaction of three transcription factors, Rap1, Fhl1, and Ifh1. Of these, only Rap1 binds directly to DNA and only Ifh1 is absent when transcription is repressed...
  3. Kim M, Hahn J. Role of CK2-dependent phosphorylation of Ifh1 and Crf1 in transcriptional regulation of ribosomal protein genes in Saccharomyces cerevisiae. Biochim Biophys Acta. 2016;1859:1004-13 pubmed publisher
    ..Fhl1 is involved in the regulation of ribosomal protein (RP) genes through interaction with either its coactivator Ifh1 or corepressor Crf1, depending on nutrient conditions...
  4. Jorgensen P, Rupes I, Sharom J, Schneper L, Broach J, Tyers M. A dynamic transcriptional network communicates growth potential to ribosome synthesis and critical cell size. Genes Dev. 2004;18:2491-505 pubmed
    ..In turn, Sfp1 influences the nuclear localization of Fhl1 and Ifh1, which bind to RP gene promoters...
  5. Rudra D, Zhao Y, Warner J. Central role of Ifh1p-Fhl1p interaction in the synthesis of yeast ribosomal proteins. EMBO J. 2005;24:533-42 pubmed
    ..The basis for this observation remains unknown. We now provide evidence that two factors, Fhl1p and Ifh1p, are key players in the transcription of RP genes. Both are found at transcribing RP genes in vivo...
  6. Zhong P, Melcher K. Identification and characterization of the activation domain of Ifh1, an activator of model TATA-less genes. Biochem Biophys Res Commun. 2010;392:77-82 pubmed publisher
    ..Here we have identified the AD of the RPG activator Ifh1p and demonstrate that a minimal Ifh1 AD represents a new class of AD that significantly differs from acidic ADs in ..
  7. Downey M, Knight B, Vashisht A, Seller C, Wohlschlegel J, Shore D, et al. Gcn5 and sirtuins regulate acetylation of the ribosomal protein transcription factor Ifh1. Curr Biol. 2013;23:1638-48 pubmed publisher
    ..The transcription factor Ifh1 binds at RP genes and promotes their transcription when growth conditions are favorable...