IDP3

Summary

Gene Symbol: IDP3
Description: isocitrate dehydrogenase (NADP(+)) IDP3
Alias: isocitrate dehydrogenase (NADP(+)) IDP3
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. McAlister Henn L, Small W. Molecular genetics of yeast TCA cycle isozymes. Prog Nucleic Acid Res Mol Biol. 1997;57:317-39 pubmed
  2. Henke B, Girzalsky W, Berteaux Lecellier V, Erdmann R. IDP3 encodes a peroxisomal NADP-dependent isocitrate dehydrogenase required for the beta-oxidation of unsaturated fatty acids. J Biol Chem. 1998;273:3702-11 pubmed
    ..We report the identification and functional analysis of the IDP3 gene product, which is a yeast peroxisomal NADP-dependent isocitrate dehydrogenase...
  3. Contreras Shannon V, McAlister Henn L. Influence of compartmental localization on the function of yeast NADP+-specific isocitrate dehydrogenases. Arch Biochem Biophys. 2004;423:235-46 pubmed
    ..compartmentalized isozymes of isocitrate dehydrogenase (mitochondrial IDP1, cytosolic IDP2, and peroxisomal IDP3) in the yeast Saccharomyces cerevisiae catalyze the NADP(+)-dependent oxidative decarboxylation of isocitrate to ..
  4. Lu Q, McAlister Henn L. Peroxisomal localization and function of NADP+ -specific isocitrate dehydrogenases in yeast. Arch Biochem Biophys. 2010;493:125-34 pubmed publisher
    Yeast peroxisomal NADP(+)-specific isocitrate dehydrogenase (IDP3) contains a canonical type I peroxisomal targeting sequence (a carboxyl-terminal Cys-Lys-Leu tripeptide), and provides the NADPH required for beta-oxidation of some fatty ..
  5. Oeljeklaus S, Reinartz B, Wolf J, Wiese S, Tonillo J, Podwojski K, et al. Identification of core components and transient interactors of the peroxisomal importomer by dual-track stable isotope labeling with amino acids in cell culture analysis. J Proteome Res. 2012;11:2567-80 pubmed publisher
  6. Kingsbury J, Shamaprasad N, Billmyre R, Heitman J, Cardenas M. Cancer-associated isocitrate dehydrogenase mutations induce mitochondrial DNA instability. Hum Mol Genet. 2016;25:3524-3538 pubmed publisher
    ..the analogous glioma-associated mutations into the NADP+?isocitrate dehydrogenase genes (IDP1, IDP2, IDP3) in Saccharomyces cerevisiae Intriguingly, expression of the mitochondrial IDP1R148H mutant allele ..