Gene Symbol: ICP55
Species: Saccharomyces cerevisiae S288c
Naamati A, Regev Rudzki N, Galperin S, Lill R, Pines O. Dual targeting of Nfs1 and discovery of its novel processing enzyme, Icp55. J Biol Chem. 2009;284:30200-8 pubmed publisher
..This led to the discovery of a novel mitochondrial processing enzyme, Icp55. This enzyme removes three amino acids from the N terminus of Nfs1 after cleavage by mitochondrial processing ..
Vögtle F, Wortelkamp S, Zahedi R, Becker D, Leidhold C, Gevaert K, et al
. Global analysis of the mitochondrial N-proteome identifies a processing peptidase critical for protein stability. Cell. 2009;139:428-39 pubmed publisher
..We identified the intermediate cleaving peptidase Icp55, which removes an amino acid from a characteristic set of MPP-generated N-termini, solving the controversial ..
Stames E, O Toole J. Mitochondrial aminopeptidase deletion increases chronological lifespan and oxidative stress resistance while decreasing respiratory metabolism in S. cerevisiae. PLoS ONE. 2013;8:e77234 pubmed publisher
Recessive mutations in XPNPEP3, encoding a mitochondrial x-prolyl aminopeptidase, have been identified in families with a rare hereditary tubulointerstitial kidney disease...
Venne A, Vögtle F, Meisinger C, Sickmann A, Zahedi R. Novel highly sensitive, specific, and straightforward strategy for comprehensive N-terminal proteomics reveals unknown substrates of the mitochondrial peptidase Icp55. J Proteome Res. 2013;12:3823-30 pubmed publisher
..Using ChaFRADIC we compared mitochondrial proteins from wild-type and icp55? yeast (30 ?g each)...