HYM1

Summary

Gene Symbol: HYM1
Description: Hym1p
Alias: Hym1p
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Bidlingmaier S, Weiss E, Seidel C, Drubin D, Snyder M. The Cbk1p pathway is important for polarized cell growth and cell separation in Saccharomyces cerevisiae. Mol Cell Biol. 2001;21:2449-62 pubmed
    ..Our results suggest that Cbk1p and Hym1p function to regulate two distinct cell morphogenesis pathways: an ACE2-independent pathway that is required for ..
  2. Bogomolnaya L, Pathak R, Guo J, Polymenis M. Roles of the RAM signaling network in cell cycle progression in Saccharomyces cerevisiae. Curr Genet. 2006;49:384-92 pubmed
    The Saccharomyces cerevisiae Hym1p, Mob2p, Tao3p, Cbk1p, Sog2p and Kic1p proteins are thought to function together in the RAM signaling network, which controls polarized growth, cell separation and cell integrity...
  3. Panozzo C, Bourens M, Nowacka A, Herbert C. Mutations in the C-terminus of the conserved NDR kinase, Cbk1p of Saccharomyces cerevisiae, make the protein independent of upstream activators. Mol Genet Genomics. 2010;283:111-22 pubmed publisher
    ..After a UV mutagenesis, we have isolated 115 independent extragenic suppressors of four ram mutations: tao3, hym1, kic1 and sog2...
  4. Schneper L, Krauss A, Miyamoto R, Fang S, Broach J. The Ras/protein kinase A pathway acts in parallel with the Mob2/Cbk1 pathway to effect cell cycle progression and proper bud site selection. Eukaryot Cell. 2004;3:108-20 pubmed
    ..From these observations, we conclude that the PKA pathway and Mob2/Cbk1 act in parallel to determine bud site selection and promote cell cycle progression. ..
  5. Kurischko C, Weiss G, Ottey M, Luca F. A role for the Saccharomyces cerevisiae regulation of Ace2 and polarized morphogenesis signaling network in cell integrity. Genetics. 2005;171:443-55 pubmed
    ..Collectively, these data indicate that RAM and Ssd1p function cooperatively to control cell integrity and suggest that Zrg8p and Srl1p function as nonessential inhibitors of Ssd1p. ..
  6. Mancini Lombardi I, Palani S, Meitinger F, Darieva Z, Hofmann A, Sharrocks A, et al. Lre1 directly inhibits the NDR/Lats kinase Cbk1 at the cell division site in a phosphorylation-dependent manner. Curr Biol. 2013;23:1736-45 pubmed publisher
    ..We propose that similar inhibitory proteins may also provide fine tuning for the activity of NDR kinases in other organisms. ..
  7. Jorgensen P, Nelson B, Robinson M, Chen Y, Andrews B, Tyers M, et al. High-resolution genetic mapping with ordered arrays of Saccharomyces cerevisiae deletion mutants. Genetics. 2002;162:1091-9 pubmed
    ..The Cbk1 kinase signaling pathway, which consists minimally of CBK1, MOB2, KIC1, HYM1, and TAO3 (PAG1), controls polarized morphogenesis and activation of the Ace2 transcription factor...
  8. Nelson B, Kurischko C, Horecka J, Mody M, Nair P, Pratt L, et al. RAM: a conserved signaling network that regulates Ace2p transcriptional activity and polarized morphogenesis. Mol Biol Cell. 2003;14:3782-803 pubmed
    ..Recently, a set of proteins that include Cbk1p kinase, its binding partner Mob2p, Tao3p (Pag1p), and Hym1p were shown to regulate both Ace2p activity and cellular morphogenesis...
  9. Bogomolnaya L, Pathak R, Guo J, Cham R, Aramayo R, Polymenis M. Hym1p affects cell cycle progression in Saccharomyces cerevisiae. Curr Genet. 2004;46:183-92 pubmed
    ..In yeast, Hym1p plays a role in cellular morphogenesis and also promotes the daughter cell-specific localization of the Ace2p ..

More Information

Publications11

  1. Voth W, Olsen A, Sbia M, Freedman K, Stillman D. ACE2, CBK1, and BUD4 in budding and cell separation. Eukaryot Cell. 2005;4:1018-28 pubmed
    Mutations in the RAM network genes, including CBK1, MOB2, KIC1, HYM1, and TAO3, cause defects in bud site selection, asymmetric apical growth, and mating projections...
  2. Hsu J, Weiss E. Cell cycle regulated interaction of a yeast Hippo kinase and its activator MO25/Hym1. PLoS ONE. 2013;8:e78334 pubmed publisher
    ..kinase Kic1 in fact phosphorylates the HM site of Cbk1, and show that Kic1 is allosterically activated by Hym1, a highly conserved protein related to mammalian MO25...