Gene Symbol: HUL5
Description: ubiquitin-ubiquitin ligase HUL5
Alias: ubiquitin-ubiquitin ligase HUL5
Species: Saccharomyces cerevisiae S288c
Leggett D, Hanna J, Borodovsky A, Crosas B, Schmidt M, Baker R, et al
. Multiple associated proteins regulate proteasome structure and function. Mol Cell. 2002;10:495-507 pubmed
..The major components are a deubiquitinating enzyme (Ubp6), a ubiquitin-ligase (Hul5), and an uncharacterized protein (Ecm29). Ecm29 tethers the proteasome core particle to the regulatory particle...
Fang N, Ng A, Measday V, Mayor T. Hul5 HECT ubiquitin ligase plays a major role in the ubiquitylation and turnover of cytosolic misfolded proteins. Nat Cell Biol. 2011;13:1344-52 pubmed publisher
..We discover that the Hul5 HECT ubiquitin ligase participates in this heat-shock stress response...
Braten O, Shabek N, Kravtsova Ivantsiv Y, Ciechanover A. Generation of free ubiquitin chains is up-regulated in stress and facilitated by the HECT domain ubiquitin ligases UFD4 and HUL5. Biochem J. 2012;444:611-7 pubmed publisher
..However, it appears that the stress-induced synthesis of free chains is catalyzed by a different ligase, HUL5 (HECT ubiquitin ligase 5), which is also a HECT domain E3.
Fang N, Mayor T. Hul5 ubiquitin ligase: good riddance to bad proteins. Prion. 2012;6:240-4 pubmed publisher
..We discovered that the Hul5 ubiquitin ligase is a major player in a novel protein quality control pathway that targets cytosolic misfolded ..
Crosas B, Hanna J, Kirkpatrick D, Zhang D, Tone Y, Hathaway N, et al
. Ubiquitin chains are remodeled at the proteasome by opposing ubiquitin ligase and deubiquitinating activities. Cell. 2006;127:1401-13 pubmed
The ubiquitin ligase Hul5 was recently identified as a component of the proteasome, a multisubunit protease that degrades ubiquitin-protein conjugates...
Kohlmann S, Schafer A, Wolf D. Ubiquitin ligase Hul5 is required for fragment-specific substrate degradation in endoplasmic reticulum-associated degradation. J Biol Chem. 2008;283:16374-83 pubmed publisher
..We identified the strain deleted for the ubiquitin chain elongating ligase Hul5 among the mutant strains with a strong growth phenotype...
Fang N, Chan G, Zhu M, Comyn S, Persaud A, Deshaies R, et al
. Rsp5/Nedd4 is the main ubiquitin ligase that targets cytosolic misfolded proteins following heat stress. Nat Cell Biol. 2014;16:1227-37 pubmed publisher
..Our results support a bipartite recognition mechanism combining direct and chaperone-dependent ubiquitylation of misfolded cytosolic proteins by Rsp5. ..
Aviram S, Kornitzer D. The ubiquitin ligase Hul5 promotes proteasomal processivity. Mol Cell Biol. 2010;30:985-94 pubmed publisher
..b>Hul5 is a 19S subcomplex-associated ubiquitin ligase that elongates ubiquitin chains on proteasome-bound substrates...