HUL5

Summary

Gene Symbol: HUL5
Description: ubiquitin-ubiquitin ligase HUL5
Alias: ubiquitin-ubiquitin ligase HUL5
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Leggett D, Hanna J, Borodovsky A, Crosas B, Schmidt M, Baker R, et al. Multiple associated proteins regulate proteasome structure and function. Mol Cell. 2002;10:495-507 pubmed
    ..The major components are a deubiquitinating enzyme (Ubp6), a ubiquitin-ligase (Hul5), and an uncharacterized protein (Ecm29). Ecm29 tethers the proteasome core particle to the regulatory particle...
  2. Fang N, Ng A, Measday V, Mayor T. Hul5 HECT ubiquitin ligase plays a major role in the ubiquitylation and turnover of cytosolic misfolded proteins. Nat Cell Biol. 2011;13:1344-52 pubmed publisher
    ..We discover that the Hul5 HECT ubiquitin ligase participates in this heat-shock stress response...
  3. Braten O, Shabek N, Kravtsova Ivantsiv Y, Ciechanover A. Generation of free ubiquitin chains is up-regulated in stress and facilitated by the HECT domain ubiquitin ligases UFD4 and HUL5. Biochem J. 2012;444:611-7 pubmed publisher
    ..However, it appears that the stress-induced synthesis of free chains is catalyzed by a different ligase, HUL5 (HECT ubiquitin ligase 5), which is also a HECT domain E3.
  4. Fang N, Mayor T. Hul5 ubiquitin ligase: good riddance to bad proteins. Prion. 2012;6:240-4 pubmed publisher
    ..We discovered that the Hul5 ubiquitin ligase is a major player in a novel protein quality control pathway that targets cytosolic misfolded ..
  5. Crosas B, Hanna J, Kirkpatrick D, Zhang D, Tone Y, Hathaway N, et al. Ubiquitin chains are remodeled at the proteasome by opposing ubiquitin ligase and deubiquitinating activities. Cell. 2006;127:1401-13 pubmed
    The ubiquitin ligase Hul5 was recently identified as a component of the proteasome, a multisubunit protease that degrades ubiquitin-protein conjugates...
  6. Kohlmann S, Schafer A, Wolf D. Ubiquitin ligase Hul5 is required for fragment-specific substrate degradation in endoplasmic reticulum-associated degradation. J Biol Chem. 2008;283:16374-83 pubmed publisher
    ..We identified the strain deleted for the ubiquitin chain elongating ligase Hul5 among the mutant strains with a strong growth phenotype...
  7. Fang N, Chan G, Zhu M, Comyn S, Persaud A, Deshaies R, et al. Rsp5/Nedd4 is the main ubiquitin ligase that targets cytosolic misfolded proteins following heat stress. Nat Cell Biol. 2014;16:1227-37 pubmed publisher
    ..Our results support a bipartite recognition mechanism combining direct and chaperone-dependent ubiquitylation of misfolded cytosolic proteins by Rsp5. ..
  8. Aviram S, Kornitzer D. The ubiquitin ligase Hul5 promotes proteasomal processivity. Mol Cell Biol. 2010;30:985-94 pubmed publisher
    ..b>Hul5 is a 19S subcomplex-associated ubiquitin ligase that elongates ubiquitin chains on proteasome-bound substrates...