Gene Symbol: HUL4
Description: putative E3 ubiquitin-protein ligase HUL4
Species: Saccharomyces cerevisiae S288c
Wang G, Yang J, Huibregtse J. Functional domains of the Rsp5 ubiquitin-protein ligase. Mol Cell Biol. 1999;19:342-52 pubmed
..In addition, we show that haploid yeast strains bearing complete disruptions of either of two other hect E3 genes of yeast, designated HUL4 (YJR036C) and HUL5 (YGL141W), are viable.
Tedrick K, Trischuk T, Lehner R, Eitzen G. Enhanced membrane fusion in sterol-enriched vacuoles bypasses the Vrp1p requirement. Mol Biol Cell. 2004;15:4609-21 pubmed
..Therefore, the Vrp1p/Las17p requirement for membrane fusion is bypassed by increased sterols, which promotes actin remodeling as part the membrane fusion mechanism. ..
Vanacova S, Wolf J, Martin G, Blank D, Dettwiler S, Friedlein A, et al
. A new yeast poly(A) polymerase complex involved in RNA quality control. PLoS Biol. 2005;3:e189 pubmed
..This polyadenylation-mediated RNA surveillance resembles the role of polyadenylation in bacterial RNA turnover. ..
Khmelinskii A, Blaszczak E, Pantazopoulou M, Fischer B, Omnus D, Le Dez G, et al
. Protein quality control at the inner nuclear membrane. Nature. 2014;516:410-3 pubmed publisher
..We show that the Asi ubiquitin ligase is involved in degradation of mislocalized integral membrane proteins, thus acting to maintain and safeguard the identity of the INM. ..
La Ferla M, Mercatanti A, Rocchi G, Lodovichi S, Cervelli T, Pignata L, et al
. Expression of human poly (ADP-ribose) polymerase 1 in Saccharomyces cerevisiae: Effect on survival, homologous recombination and identification of genes involved in intracellular localization. Mutat Res. 2015;774:14-24 pubmed publisher
..level was altered in strains which are deleted for the transcription regulator GAL3, the histone H1 gene HHO1, the HUL4 gene, the deubiquitination enzyme gene OTU1, the nuclear pore protein POM152 and the SNT1 that encodes for the ..