HTL1

Summary

Gene Symbol: HTL1
Description: Htl1p
Alias: Htl1p
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Romeo M, Angus Hill M, Sobering A, Kamada Y, Cairns B, Levin D. HTL1 encodes a novel factor that interacts with the RSC chromatin remodeling complex in Saccharomyces cerevisiae. Mol Cell Biol. 2002;22:8165-74 pubmed
    ..Here we identify Htl1 as a novel factor that associates with the RSC complex both physically and functionally...
  2. Florio C, Moscariello M, Ederle S, Fasano R, Lanzuolo C, Pulitzer J. A study of biochemical and functional interactions of Htl1p, a putative component of the Saccharomyces cerevisiae, Rsc chromatin-remodeling complex. Gene. 2007;395:72-85 pubmed
    ..Yeast, 18, 1317-1330]. Genetic interactions and co-immunoprecipitation experiments indicate a role for Htl1p in functions controlled by RSC, a multiprotein, ATP-dependent, chromatin-remodeling complex [Lu, Y.M., Lin, Y.R...
  3. Lu Y, Lin Y, Tsai A, Hsao Y, Li C, Cheng M. Dissecting the pet18 mutation in Saccharomyces cerevisiae: HTL1 encodes a 7-kDa polypeptide that interacts with components of the RSC complex. Mol Genet Genomics. 2003;269:321-30 pubmed
    ..We demonstrated that Rsc8p interacts physically with Htl1p, and that the genes RSC3, STH1 and RSC30 interact with HTL1...
  4. Lia G, Praly E, Ferreira H, Stockdale C, Tse Dinh Y, Dunlap D, et al. Direct observation of DNA distortion by the RSC complex. Mol Cell. 2006;21:417-25 pubmed
    ..These observations support the idea that the ATPase motors of the Snf2 family of proteins act as DNA translocases specialized to generate transient distortions in DNA structure. ..
  5. Carey M, Li B, Workman J. RSC exploits histone acetylation to abrogate the nucleosomal block to RNA polymerase II elongation. Mol Cell. 2006;24:481-7 pubmed
    ..Thus, RSC can recognize acetylated nucleosomes and facilitate passage of Pol II through them. These data support the view that histone modifications regulate accessibility of the coding region to Pol II. ..
  6. Fischer C, Saha A, Cairns B. Kinetic model for the ATP-dependent translocation of Saccharomyces cerevisiae RSC along double-stranded DNA. Biochemistry. 2007;46:12416-26 pubmed
    ..These results are further discussed in the context of previously published studies of RSC and other DNA translocases. ..
  7. Andress E, Holic R, Edelmann M, Kessler B, Yu V. Dia2 controls transcription by mediating assembly of the RSC complex. PLoS ONE. 2011;6:e21172 pubmed publisher
    ..Dia2, by controlling the RSC chromatin remodeller, fine-tunes transcription by controlling nucleosome positioning during transcriptional activation and repression. ..
  8. Zhang Y, Smith C, Saha A, Grill S, Mihardja S, Smith S, et al. DNA translocation and loop formation mechanism of chromatin remodeling by SWI/SNF and RSC. Mol Cell. 2006;24:559-68 pubmed
    ..Such loop formation may provide a molecular basis for the biological functions of remodelers. ..
  9. Chang M, Bellaoui M, Boone C, Brown G. A genome-wide screen for methyl methanesulfonate-sensitive mutants reveals genes required for S phase progression in the presence of DNA damage. Proc Natl Acad Sci U S A. 2002;99:16934-9 pubmed
    ..These genes may promote replication fork stability or processivity during encounters between replication forks and DNA damage. ..

More Information

Publications12

  1. Lorch Y, Maier Davis B, Kornberg R. Chromatin remodeling by nucleosome disassembly in vitro. Proc Natl Acad Sci U S A. 2006;103:3090-3 pubmed
    ..RSC and related chromatin-remodeling complexes may be responsible for the removal of promoter nucleosomes during transcriptional activation in vivo. ..
  2. Tian R, Hoa X, Lambert J, Pezacki J, Veres T, Figeys D. Development of a multiplexed microfluidic proteomic reactor and its application for studying protein-protein interactions. Anal Chem. 2011;83:4095-102 pubmed publisher
  3. Wang S, Cheng M. The defects in cell wall integrity and G2-M transition of the ?htl1 mutant are interconnected. Yeast. 2012;29:45-57 pubmed publisher
    ..Here we investigate the cellular functioning of HTL1, which encodes a non-essential subunit of the RSC complex...