Gene Symbol: HSP31
Description: glutathione-independent methylglyoxalase
Alias: glutathione-independent methylglyoxalase
Species: Saccharomyces cerevisiae S288c
Wilson M, St Amour C, Collins J, Ringe D, Petsko G. The 1.8-A resolution crystal structure of YDR533Cp from Saccharomyces cerevisiae: a member of the DJ-1/ThiJ/PfpI superfamily. Proc Natl Acad Sci U S A. 2004;101:1531-6 pubmed
..The structure indicates that the closest relative to YDR533Cp is the Escherichia coli heat shock protein Hsp31 (YedU), which has both chaperone and protease activity...
Tsai C, Aslam K, Drendel H, Asiago J, Goode K, PAUL L, et al
. Hsp31 Is a Stress Response Chaperone That Intervenes in the Protein Misfolding Process. J Biol Chem. 2015;290:24816-34 pubmed publisher
The Saccharomyces cerevisiae heat shock protein Hsp31 is a stress-inducible homodimeric protein that is involved in diauxic shift reprogramming and has glyoxalase activity...
Bankapalli K, Saladi S, Awadia S, Goswami A, Samaddar M, D Silva P. Robust glyoxalase activity of Hsp31, a ThiJ/DJ-1/PfpI family member protein, is critical for oxidative stress resistance in Saccharomyces cerevisiae. J Biol Chem. 2015;290:26491-507 pubmed publisher
..In this report, we demonstrate that Hsp31 protein, a member of the ThiJ/DJ-1/PfpI family in Saccharomyces cerevisiae, plays an indispensable role in ..
Aslam K, Hazbun T. Hsp31, a member of the DJ-1 superfamily, is a multitasking stress responder with chaperone activity. Prion. 2016;10:103-11 pubmed publisher
..b>Hsp31 is a homodimeric protein structurally similar to human DJ-1, a Parkinson's disease-linked protein, and both are ..
Aslam K, Tsai C, Hazbun T. The small heat shock protein Hsp31 cooperates with Hsp104 to modulate Sup35 prion aggregation. Prion. 2016;10:444-465 pubmed
The yeast homolog of DJ-1, Hsp31, is a multifunctional protein that is involved in several cellular pathways including detoxification of the toxic metabolite methylglyoxal and as a protein deglycase...
de Nobel H, Lawrie L, Brul S, Klis F, Davis M, Alloush H, et al
. Parallel and comparative analysis of the proteome and transcriptome of sorbic acid-stressed Saccharomyces cerevisiae. Yeast. 2001;18:1413-28 pubmed
..Subsequently, we demonstrated that a deletion mutant of Hsp26 was sensitive to sorbic acid. Thus, the induction of Hsp26, which occurs during adaptation to sorbic acid, confers resistance to the inhibitory effects of this compound. ..
Skoneczna A, Miciałkiewicz A, Skoneczny M. Saccharomyces cerevisiae Hsp31p, a stress response protein conferring protection against reactive oxygen species. Free Radic Biol Med. 2007;42:1409-20 pubmed
The Saccharomyces cerevisiae HSP31 (YDR533c) gene encodes a protein that belongs to the DJ-1/PfpI family and its function is unknown...
Hasim S, Hussin N, Alomar F, Bidasee K, Nickerson K, Wilson M. A glutathione-independent glyoxalase of the DJ-1 superfamily plays an important role in managing metabolically generated methylglyoxal in Candida albicans. J Biol Chem. 2014;289:1662-74 pubmed publisher
..A close Glx3p homolog from Saccharomyces cerevisiae (YDR533C/Hsp31) also has glyoxalase activity, suggesting that fungal members of the Hsp31 clade of the DJ-1 superfamily are all ..
Miller Fleming L, Antas P, Pais T, Smalley J, Giorgini F, Outeiro T. Yeast DJ-1 superfamily members are required for diauxic-shift reprogramming and cell survival in stationary phase. Proc Natl Acad Sci U S A. 2014;111:7012-7 pubmed publisher
The yeast Hsp31 minifamily proteins (Hsp31, Hsp32, Hsp33, Hsp34) belong to the highly conserved DJ-1 superfamily. The human DJ-1 protein is associated with cancer and neurodegenerative disorders, such as Parkinson disease...