HSM3

Summary

Gene Symbol: HSM3
Description: Hsm3p
Alias: Hsm3p
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Barrault M, Richet N, Godard C, Murciano B, Le Tallec B, Rousseau E, et al. Dual functions of the Hsm3 protein in chaperoning and scaffolding regulatory particle subunits during the proteasome assembly. Proc Natl Acad Sci U S A. 2012;109:E1001-10 pubmed publisher
    ..The assembly of 19S RP base subcomplex is mediated by multiple dedicated chaperones. Among these, Hsm3 is important for normal growth and directly targets the carboxyl-terminal (C-terminal) domain of Rpt1 of the Rpt1-..
  2. Park S, Roelofs J, Kim W, Robert J, Schmidt M, Gygi S, et al. Hexameric assembly of the proteasomal ATPases is templated through their C termini. Nature. 2009;459:866-70 pubmed publisher
    ..We have also identified an apparent intermediate in base assembly, BP1, which contains Rpn1, three Rpts and Hsm3, a chaperone for base assembly...
  3. Funakoshi M, Tomko R, Kobayashi H, Hochstrasser M. Multiple assembly chaperones govern biogenesis of the proteasome regulatory particle base. Cell. 2009;137:887-99 pubmed publisher
    ..Other RP subcomplexes contain Hsm3, which is related to mammalian proteasome subunit S5b. Hsm3 also contributes to base assembly...
  4. Saeki Y, Toh e A, Kudo T, Kawamura H, Tanaka K. Multiple proteasome-interacting proteins assist the assembly of the yeast 19S regulatory particle. Cell. 2009;137:900-13 pubmed publisher
    ..Here, we show that four proteasome-interacting proteins (PIPs), Nas2/p27, Nas6/gankyrin, Rpn14/PAAF1, and Hsm3/S5b, bind specific Rpt subunits of the RP and interact each other genetically...
  5. Takagi K, Kim S, Yukii H, Ueno M, Morishita R, Endo Y, et al. Structural basis for specific recognition of Rpt1p, an ATPase subunit of 26 S proteasome, by proteasome-dedicated chaperone Hsm3p. J Biol Chem. 2012;287:12172-82 pubmed publisher
    ..b>Hsm3, a 19 S RP dedicated chaperone, transiently binds to the C-terminal domain of the Rpt1 subunit and forms a ..
  6. Le Tallec B, Barrault M, Guerois R, Carré T, Peyroche A. Hsm3/S5b participates in the assembly pathway of the 19S regulatory particle of the proteasome. Mol Cell. 2009;33:389-99 pubmed publisher
    ..Here we characterize the yeast Hsm3 protein, which displays unique features regarding 19S assembly...
  7. Tomko R, Funakoshi M, Schneider K, Wang J, Hochstrasser M. Heterohexameric ring arrangement of the eukaryotic proteasomal ATPases: implications for proteasome structure and assembly. Mol Cell. 2010;38:393-403 pubmed publisher
    ..Finally, the ATPase ring structure casts light on alternative RP structural models and the mechanism of RP action. ..
  8. Chernenkov A, Fedorov D, Kosareva A, Kozhina T, Korolev V. [Spontaneous mutation rate changes in saccharomyces cerevisiae at combinations of hsm3 and hsm6 mutations with rad52 mutation]. Genetika. 2014;50:243-5 pubmed
    ..Combinations of hsm3 and hsm6 mutations with the rad52 mutation lead to a decrease of the spontaneous mutation rate mediated by DNA ..
  9. De La Mota Peynado A, Lee S, Pierce B, Wani P, Singh C, Roelofs J. The proteasome-associated protein Ecm29 inhibits proteasomal ATPase activity and in vivo protein degradation by the proteasome. J Biol Chem. 2013;288:29467-81 pubmed publisher
    ..We propose that the inhibitory ability of Ecm29 is important for its function as a proteasome quality control factor by ensuring that aberrant proteasomes recognized by Ecm29 are inactive. ..

More Information

Publications20

  1. Chernenkov A, Gracheva L, Evstiukhina T, Koval tsova S, Peshekhonov V, Fedorova I, et al. [Interaction of gene HSM3 with genes of the epistatic RAD6 group in yeast Saccharomyces cerevisiae]. Genetika. 2012;48:160-7 pubmed
    ..The results of our recent studies show that gene HSM3 participating in the control of adaptive mutagenesis increases the frequency of mutations induced by different ..
  2. Chernenkov A, Ivanova S, Koval tsova S, Gracheva L, Peshekhonov V, Fedorova I, et al. [Genetic analysis of the Hsm3 protein domain structure in yeast Saccharomyces cerevisiae]. Genetika. 2010;46:742-9 pubmed
    Gene HSM3 encodes the Hsm3 protein involved in the minor branch in the system responsible for the correction of mismatched bases in DNA structure and controls replicative and reparative spontaneous mutagenesis in yeast Saccharomyces ..
  3. Fedorova I, Kovaltzova S, Gracheva L, Evstuhina T, Korolev V. Requirement of HSM3 gene for spontaneous mutagenesis in Saccharomyces cerevisiae. Mutat Res. 2004;554:67-75 pubmed
    ..The participation of the Hsm3p in spontaneous mutagenesis in slowly and activity dividing yeast cells is discussed.
  4. Alekseev S, Kovaltsova S, Fedorova I, Gracheva L, Evstukhina T, Peshekhonov V, et al. HSM2 (HMO1) gene participates in mutagenesis control in yeast Saccharomyces cerevisiae. DNA Repair (Amst). 2002;1:287-97 pubmed
    ..DNA repair pathways (rad2 and rev3) or in a mismatch repair gene (pms1 and recently characterized in our laboratory hsm3). The frequency of UV-induced mutations in hsm2 rev3 was not altered in comparison with single rev3 mutant...
  5. Chernenkov A, Fedorov D, Gracheva L, Evstukhina T, Koval tsova S, Peshekhonov V, et al. [Interaction of the HSM3 gene with genes initiating homologous recombination repair in yeast Saccharomyces cerevisiae]. Genetika. 2012;48:333-9 pubmed
    ..As a next step, genetic analysis was performed to study the interactions between the hsm3 mutation and mutations of the genes that control the initial steps of the D-loop formation...
  6. Park S, Li X, Kim H, Singh C, Tian G, Hoyt M, et al. Reconfiguration of the proteasome during chaperone-mediated assembly. Nature. 2013;497:512-6 pubmed publisher
    ..This complex is subject to active dissociation by the chaperones Hsm3, Nas6 and Rpn14...
  7. Koval tsova S, Gracheva L, Evstiukhina T, Fedorova I, Alekseev S, Korolev V. [Mutator genes of the yeast Saccharomyces cerevisiae. Interaction of mutations him and his with mutations blocking three principal pathways of repair of induced DNA damage]. Genetika. 1996;32:1061-7 pubmed
    ..On the other hand, mutation rad2 synergistically interacts with mutations him1, hsm1, hsm3, hsm6, and hsm2, thus enhancing the frequency of UV-induced mutagenesis in double mutants multiple times...
  8. Lee S, De La Mota Peynado A, Roelofs J. Loss of Rpt5 protein interactions with the core particle and Nas2 protein causes the formation of faulty proteasomes that are inhibited by Ecm29 protein. J Biol Chem. 2011;286:36641-51 pubmed publisher
    ..this apparent role as negative regulator, the deletion of ECM29 rescues the phenotypes of rpt5-?3 and nas2? in an hsm3? background...
  9. Kelberg E, Kovaltsova S, Alekseev S, Fedorova I, Gracheva L, Evstukhina T, et al. HIM1, a new yeast Saccharomyces cerevisiae gene playing a role in control of spontaneous and induced mutagenesis. Mutat Res. 2005;578:64-78 pubmed
    ..rad2, rev3, and rad54, blocking three principal DNA repair pathways; pms1, blocking mismatch repair; hsm2 and hsm3 mutations, which lead to a mutator effect...
  10. Bashore C, Dambacher C, Goodall E, Matyskiela M, Lander G, Martin A. Ubp6 deubiquitinase controls conformational dynamics and substrate degradation of the 26S proteasome. Nat Struct Mol Biol. 2015;22:712-9 pubmed publisher
    ..Ubp6 may thus act as a ubiquitin-dependent 'timer' to coordinate individual processing steps at the proteasome and modulate substrate degradation. ..
  11. Fedorova I, Kovaltzova S, Korolev V. The yeast HSM3 gene is involved in DNA mismatch repair in slowly dividing cells. Genetics. 2000;154:495-6 pubmed