Gene Symbol: HSL7
Description: protein arginine N-methyltransferase
Alias: protein arginine N-methyltransferase
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Sayegh J, Clarke S. Hsl7 is a substrate-specific type II protein arginine methyltransferase in yeast. Biochem Biophys Res Commun. 2008;372:811-5 pubmed publisher
    The Saccharomyces cerevisiae protein Hsl7 is a regulator of the Swe1 protein kinase in cell cycle checkpoint control...
  2. McMillan J, Longtine M, Sia R, Theesfeld C, Bardes E, Pringle J, et al. The morphogenesis checkpoint in Saccharomyces cerevisiae: cell cycle control of Swe1p degradation by Hsl1p and Hsl7p. Mol Cell Biol. 1999;19:6929-39 pubmed
    ..These findings suggest that Hsl1p and Hsl7p interact directly with Swe1p to promote its recognition by the ubiquitination complex, leading ultimately to its destruction. ..
  3. Shulewitz M, Inouye C, Thorner J. Hsl7 localizes to a septin ring and serves as an adapter in a regulatory pathway that relieves tyrosine phosphorylation of Cdc28 protein kinase in Saccharomyces cerevisiae. Mol Cell Biol. 1999;19:7123-37 pubmed
    ..The HSL1 and HSL7 gene products act as negative regulators of Swe1...
  4. Cid V, Shulewitz M, McDonald K, Thorner J. Dynamic localization of the Swe1 regulator Hsl7 during the Saccharomyces cerevisiae cell cycle. Mol Biol Cell. 2001;12:1645-69 pubmed
    ..Swe1 is itself negatively regulated by Hsl1, a Nim1-related protein kinase, and by Hsl7, a presumptive protein-arginine methyltransferase...
  5. Ma X, Lu Q, Grunstein M. A search for proteins that interact genetically with histone H3 and H4 amino termini uncovers novel regulators of the Swe1 kinase in Saccharomyces cerevisiae. Genes Dev. 1996;10:1327-40 pubmed
    ..Another gene, HSL7, is a novel negative regulator of Swe1 function...
  6. Crutchley J, King K, Keaton M, Szkotnicki L, Orlando D, Zyla T, et al. Molecular dissection of the checkpoint kinase Hsl1p. Mol Biol Cell. 2009;20:1926-36 pubmed publisher
    ..We suggest that Hsl1p responds to alterations in septin organization, which themselves occur in response to the local geometry of the cell cortex. ..
  7. Longtine M, Theesfeld C, McMillan J, Weaver E, Pringle J, Lew D. Septin-dependent assembly of a cell cycle-regulatory module in Saccharomyces cerevisiae. Mol Cell Biol. 2000;20:4049-61 pubmed
    ..e., after a bud has formed). ..
  8. Miranda T, Sayegh J, Frankel A, Katz J, Miranda M, Clarke S. Yeast Hsl7 (histone synthetic lethal 7) catalyses the in vitro formation of omega-N(G)-monomethylarginine in calf thymus histone H2A. Biochem J. 2006;395:563-70 pubmed
    The HSL7 (histone synthetic lethal 7) gene in the yeast Saccharomyces cerevisiae encodes a protein with close sequence similarity to the mammalian PRMT5 protein, a member of the class of protein arginine methyltransferases that catalyses ..
  9. King K, Jin M, Lew D. Roles of Hsl1p and Hsl7p in Swe1p degradation: beyond septin tethering. Eukaryot Cell. 2012;11:1496-502 pubmed publisher
    ..However, both Hsl1p and Hsl7p are still required for Swe1p degradation, implying that these proteins play additional roles beyond localizing Swe1p to the neck. ..

More Information


  1. McMillan J, Theesfeld C, Harrison J, Bardes E, Lew D. Determinants of Swe1p degradation in Saccharomyces cerevisiae. Mol Biol Cell. 2002;13:3560-75 pubmed
    ..The other region did not appear to affect interactions with known Swe1p regulators, suggesting that other as-yet-unknown regulators exist. ..
  2. Theesfeld C, Zyla T, Bardes E, Lew D. A monitor for bud emergence in the yeast morphogenesis checkpoint. Mol Biol Cell. 2003;14:3280-91 pubmed
    ..We discuss models for translating cellular geometry (in this case, the emergence of a bud) into biochemical signals regulating cell proliferation. ..
  3. Szkotnicki L, Crutchley J, Zyla T, Bardes E, Lew D. The checkpoint kinase Hsl1p is activated by Elm1p-dependent phosphorylation. Mol Biol Cell. 2008;19:4675-86 pubmed publisher
    ..We identified elm1 mutants in a screen for defects in Swe1p degradation and show that a phosphomimic T273E mutation in HSL1 bypasses the need for Elm1p in this pathway. ..
  4. Ruault M, Pillus L. Chromatin-modifiying enzymes are essential when the Saccharomyces cerevisiae morphogenesis checkpoint is constitutively activated. Genetics. 2006;174:1135-49 pubmed
    ..b>HSL7 is also essential in the absence of the N-terminal tails of histones H3 or H4...
  5. Kang H, Tsygankov D, Lew D. Sensing a bud in the yeast morphogenesis checkpoint: a role for Elm1. Mol Biol Cell. 2016;27:1764-75 pubmed publisher
    ..Swe1 is localized to the septin cytoskeleton at the bud neck by the Swe1-binding protein Hsl7. Neck localization of Swe1 is required for Swe1 degradation...
  6. Yasutis K, Vignali M, Ryder M, Tameire F, Dighe S, Fields S, et al. Zds2p regulates Swe1p-dependent polarized cell growth in Saccharomyces cerevisiae via a novel Cdc55p interaction domain. Mol Biol Cell. 2010;21:4373-86 pubmed publisher
    ..This negative regulation requires the CDC55 gene. Together these data indicate that the Cdc55p/Zds2p module has a function in the regulation of the Swe1p-dependent G2/M checkpoint. ..
  7. Liu H, Wang Y. The function and regulation of budding yeast Swe1 in response to interrupted DNA synthesis. Mol Biol Cell. 2006;17:2746-56 pubmed
    ..Therefore, S-phase accumulated Swe1 prevents Clb2-Cdk1-mediated mitotic activities, but has little effects on Clb5-Cdk1-associated S-phase progression. ..
  8. Wang M, Collins R. A lysine deacetylase Hos3 is targeted to the bud neck and involved in the spindle position checkpoint. Mol Biol Cell. 2014;25:2720-34 pubmed publisher
    ..The morphogenesis checkpoint member Hsl7 recruits Hos3 to the neck region. Cells with a defect in spindle orientation trigger Hos3 to load onto both SPBs...
  9. Pei Y, Niu L, Lu F, Liu C, Zhai J, Kong X, et al. Mutations in the Type II protein arginine methyltransferase AtPRMT5 result in pleiotropic developmental defects in Arabidopsis. Plant Physiol. 2007;144:1913-23 pubmed
    ..Therefore, the type II protein Arg methyltransferase AtPRMT5 is involved in promotion of vegetative growth and FLC-dependent flowering time regulation in Arabidopsis. ..
  10. King K, Kang H, Jin M, Lew D. Feedback control of Swe1p degradation in the yeast morphogenesis checkpoint. Mol Biol Cell. 2013;24:914-22 pubmed publisher
    ..They also highlight the difficulty in disentangling direct checkpoint pathways from the effects of positive-feedback loops active at the G2/M transition. ..
  11. Fujita A, Tonouchi A, Hiroko T, Inose F, Nagashima T, Satoh R, et al. Hsl7p, a negative regulator of Ste20p protein kinase in the Saccharomyces cerevisiae filamentous growth-signaling pathway. Proc Natl Acad Sci U S A. 1999;96:8522-7 pubmed
    ..We identified a mutant, hsl7, that exhibits filamentous growth on rich medium. Hsl7p belongs to a highly conserved protein family in eukaryotes...
  12. Loewen C, Young B, Tavassoli S, Levine T. Inheritance of cortical ER in yeast is required for normal septin organization. J Cell Biol. 2007;179:467-83 pubmed
    ..This perturbation leads to a delay in the transition through G2, activating the Saccharomyces wee1 kinase (Swe1) and the morphogenesis checkpoint. Thus, we identify a mechanism involved in sensing the distribution of ER. ..