Gene Symbol: HRB1
Description: mRNA-binding protein
Alias: TOM34, mRNA-binding protein
Species: Saccharomyces cerevisiae S288c
Machell R, Ciclitira P, Farthing M, Dick A, Hunter J. Maintenance cimetidine in prevention of peptic-ulcer relapse. Lancet. 1978;1:663 pubmed
Senger B, Simos G, Bischoff F, Podtelejnikov A, Mann M, Hurt E. Mtr10p functions as a nuclear import receptor for the mRNA-binding protein Npl3p. EMBO J. 1998;17:2196-207 pubmed
..This suggests that Npl3p follows a distinct nuclear import pathway and that intranuclear release from its specific import receptor Mtr10p requires the cooperative action of both Ran-GTP and newly synthesized mRNA. ..
Windgassen M, Sturm D, Cajigas I, Gonzalez C, Seedorf M, Bastians H, et al
. Yeast shuttling SR proteins Npl3p, Gbp2p, and Hrb1p are part of the translating mRNPs, and Npl3p can function as a translational repressor. Mol Cell Biol. 2004;24:10479-91 pubmed
..Together, these data shed light onto the transformation of an exporting to a translating mRNP. ..
Zander G, Hackmann A, Bender L, Becker D, Lingner T, Salinas G, et al
. mRNA quality control is bypassed for immediate export of stress-responsive transcripts. Nature. 2016;: pubmed publisher
..In Saccharomyces cerevisiae, the shuttling RNA adaptor proteins Npl3, Gbp2, Hrb1 and Nab2 are loaded co-transcriptionally onto growing pre-mRNAs...
Shen E, Henry M, Weiss V, Valentini S, Silver P, Lee M. Arginine methylation facilitates the nuclear export of hnRNP proteins. Genes Dev. 1998;12:679-91 pubmed
..Together, these findings establish that one biological role for arginine methylation is in facilitating the export of certain hnRNPs out of the nucleus. ..
Häcker S, Krebber H. Differential export requirements for shuttling serine/arginine-type mRNA-binding proteins. J Biol Chem. 2004;279:5049-52 pubmed
..Here, we present the characterization of Hrb1, a novel component of the transported ribonucleoprotein complex in Saccharomyces cerevisiae...
Porat Z, Erez O, Kahana C. Cellular localization and phosphorylation of Hrb1p is independent of Sky1p. Biochim Biophys Acta. 2006;1763:207-13 pubmed
..Furthermore, we demonstrate that Hrb1p and additional putative Sky1p substrates, identified by computational approach, are not involved in mediating the spermine tolerant phenotype of sky1Delta cells. ..
Meinel D, Burkert Kautzsch C, Kieser A, O Duibhir E, Siebert M, Mayer A, et al
. Recruitment of TREX to the transcription machinery by its direct binding to the phospho-CTD of RNA polymerase II. PLoS Genet. 2013;9:e1003914 pubmed publisher
..In summary, we provide insight into how the phospho-code of the CTD directs mRNP formation and export through TREX recruitment...
Hackmann A, Wu H, Schneider U, Meyer K, Jung K, Krebber H. Quality control of spliced mRNAs requires the shuttling SR proteins Gbp2 and Hrb1. Nat Commun. 2014;5:3123 pubmed publisher
..Here we show that the two shuttling serine/arginine (SR)-proteins Gbp2 and Hrb1 are key surveillance factors for the selective export of spliced mRNAs in yeast...