Gene Symbol: HOG1
Description: mitogen-activated protein kinase HOG1
Alias: SSK3, mitogen-activated protein kinase HOG1
Species: Saccharomyces cerevisiae S288c
Products:     HOG1

Top Publications

  1. Yang X, Maurer K, Molanus M, Mager W, Siderius M, van der Vies S. The molecular chaperone Hsp90 is required for high osmotic stress response in Saccharomyces cerevisiae. FEMS Yeast Res. 2006;6:195-204 pubmed
    ..Hsp90 is shown to be required for proper adaptation to high osmolarity via a novel signal transduction pathway that operates parallel to the HOG pathway and requires Cdc37p. ..
  2. Proft M, Mas G, de Nadal E, Vendrell A, Noriega N, Struhl K, et al. The stress-activated Hog1 kinase is a selective transcriptional elongation factor for genes responding to osmotic stress. Mol Cell. 2006;23:241-50 pubmed
    ..Exposure of yeast to high osmolarity results in activation of the SAPK Hog1, which associates with transcription factors bound at target promoters and stimulates transcriptional initiation...
  3. Mapes J, Ota I. Nbp2 targets the Ptc1-type 2C Ser/Thr phosphatase to the HOG MAPK pathway. EMBO J. 2004;23:302-11 pubmed
    The yeast high osmolarity glycerol (HOG) pathway signals via the Pbs2 MEK and the Hog1 MAPK, whose activity requires phosphorylation of Thr and Tyr in the activation loop...
  4. Mollapour M, Piper P. Hog1 mitogen-activated protein kinase phosphorylation targets the yeast Fps1 aquaglyceroporin for endocytosis, thereby rendering cells resistant to acetic acid. Mol Cell Biol. 2007;27:6446-56 pubmed
    ..b>Hog1 MAPK is transiently activated in yeast exposed to high, toxic levels of acetic acid...
  5. Babazadeh R, Adiels C, Smedh M, Petelenz Kurdziel E, Goksör M, Hohmann S. Osmostress-induced cell volume loss delays yeast Hog1 signaling by limiting diffusion processes and by Hog1-specific effects. PLoS ONE. 2013;8:e80901 pubmed publisher
    ..Yeast Hog1, the effector protein kinase of the High Osmolarity Glycerol pathway, translocates transiently from the cytosol to ..
  6. Pelet S, Rudolf F, Nadal Ribelles M, de Nadal E, Posas F, Peter M. Transient activation of the HOG MAPK pathway regulates bimodal gene expression. Science. 2011;332:732-5 pubmed publisher
    ..The p38/Hog1 MAPK is transiently activated in response to osmotic stress, leading to rapid translocation into the nucleus and ..
  7. Bermejo C, Rodriguez E, Garcia R, Rodríguez Peña J, Rodríguez de la Concepción M, Rivas C, et al. The sequential activation of the yeast HOG and SLT2 pathways is required for cell survival to cell wall stress. Mol Biol Cell. 2008;19:1113-24 pubmed publisher
    ..The MAPKs Slt2/Mpk1 and Hog1 regulate transcriptional responses of adaptation to cell wall and osmotic stresses, respectively...
  8. Wurgler Murphy S, Maeda T, Witten E, Saito H. Regulation of the Saccharomyces cerevisiae HOG1 mitogen-activated protein kinase by the PTP2 and PTP3 protein tyrosine phosphatases. Mol Cell Biol. 1997;17:1289-97 pubmed
    In response to increases in extracellular osmolarity, Saccharomyces cerevisiae activates the HOG1 mitogen-activated protein kinase (MAPK) cascade, which is composed of a pair of redundant MAPK kinase kinases, namely, Ssk2p and Ssk22p, the ..
  9. Proft M, Struhl K. Hog1 kinase converts the Sko1-Cyc8-Tup1 repressor complex into an activator that recruits SAGA and SWI/SNF in response to osmotic stress. Mol Cell. 2002;9:1307-17 pubmed
    ..During hyperosmotic stress, Hog1 MAP kinase associates with target promoters, phosphorylates Sko1, and converts Sko1 into a transcriptional ..

More Information


  1. Sole C, Nadal Ribelles M, Kraft C, Peter M, Posas F, de Nadal E. Control of Ubp3 ubiquitin protease activity by the Hog1 SAPK modulates transcription upon osmostress. EMBO J. 2011;30:3274-84 pubmed publisher
    ..In yeast, the Hog1 SAPK has a key role in reprogramming the gene expression pattern required for cell survival upon osmostress...
  2. Proft M, Serrano R. Repressors and upstream repressing sequences of the stress-regulated ENA1 gene in Saccharomyces cerevisiae: bZIP protein Sko1p confers HOG-dependent osmotic regulation. Mol Cell Biol. 1999;19:537-46 pubmed
    ..A glutathione S-transferase-Sko1 fusion protein binds specifically to the URSCRE-ENA1 element. Furthermore, a hog1 mitogen-activated protein kinase deletion strain could not counteract repression on URSCRE-ENA1 during osmotic ..
  3. Brewster J, de Valoir T, Dwyer N, Winter E, Gustin M. An osmosensing signal transduction pathway in yeast. Science. 1993;259:1760-3 pubmed
    ..Two of these genes, HOG1 and PBS2, encode members of the mitogen-activated protein kinase (MAP kinase) and MAP kinase kinase gene families, ..
  4. Mattison C, Ota I. Two protein tyrosine phosphatases, Ptp2 and Ptp3, modulate the subcellular localization of the Hog1 MAP kinase in yeast. Genes Dev. 2000;14:1229-35 pubmed
    The MAP kinase Hog1 transiently accumulates in the nucleus upon activation. Although Hog1 nuclear export correlates with its dephosphorylation, we find that dephosphorylation is not necessary for export...
  5. de Nadal E, Casadome L, Posas F. Targeting the MEF2-like transcription factor Smp1 by the stress-activated Hog1 mitogen-activated protein kinase. Mol Cell Biol. 2003;23:229-37 pubmed
    Exposure of Saccharomyces cerevisiae to increases in extracellular osmolarity activates the stress-activated Hog1 mitogen-activated protein kinase (MAPK), which is essential for cell survival upon osmotic stress...
  6. Rep M, Krantz M, Thevelein J, Hohmann S. The transcriptional response of Saccharomyces cerevisiae to osmotic shock. Hot1p and Msn2p/Msn4p are required for the induction of subsets of high osmolarity glycerol pathway-dependent genes. J Biol Chem. 2000;275:8290-300 pubmed
    ..of the genes that required the general stress-response transcription factors Msn2p and Msn4p was also reduced in a hog1 mutant, suggesting that Msn2p/Msn4p might be regulated by the HOG pathway...
  7. Shock T, Thompson J, Yates J, Madhani H. Hog1 mitogen-activated protein kinase (MAPK) interrupts signal transduction between the Kss1 MAPK and the Tec1 transcription factor to maintain pathway specificity. Eukaryot Cell. 2009;8:606-16 pubmed publisher
    ..We also find that nuclear accumulation of Tec1 is not affected by HOG signaling. Inhibition by Hog1 is apparently indirect since it does not require any of the consensus S/TP MAPK phosphorylation sites on Tec1, its ..
  8. O Rourke S, Herskowitz I. A third osmosensing branch in Saccharomyces cerevisiae requires the Msb2 protein and functions in parallel with the Sho1 branch. Mol Cell Biol. 2002;22:4739-49 pubmed
    ..We previously used the FUS1 gene of the pheromone response pathway as a reporter to monitor cross talk in hog1 mutants...
  9. Krantz M, Ahmadpour D, Ottosson L, Warringer J, Waltermann C, Nordlander B, et al. Robustness and fragility in the yeast high osmolarity glycerol (HOG) signal-transduction pathway. Mol Syst Biol. 2009;5:281 pubmed publisher
    ..Thus, in vivo robustness data can be used to discriminate and improve mathematical models. ..
  10. Reiter W, Anrather D, Dohnal I, Pichler P, Veis J, Grøtli M, et al. Validation of regulated protein phosphorylation events in yeast by quantitative mass spectrometry analysis of purified proteins. Proteomics. 2012;12:3030-43 pubmed publisher
    ..The study of Pan1 under osmotic stress conditions in different mutant backgrounds allowed us to differentiate between mitogen-activated protein kinase Hog1 driven and Hog1 independent stress responses.
  11. Mas G, de Nadal E, Dechant R, Rodríguez de la Concepción M, Logie C, Jimeno González S, et al. Recruitment of a chromatin remodelling complex by the Hog1 MAP kinase to stress genes. EMBO J. 2009;28:326-36 pubmed publisher
    For efficient transcription, RNA PolII must overcome the presence of nucleosomes. The p38-related MAPK Hog1 is an important regulator of transcription upon osmostress in yeast and thereby it is involved in initiation and elongation...
  12. Furukawa K, Sidoux Walter F, Hohmann S. Expression of the yeast aquaporin Aqy2 affects cell surface properties under the control of osmoregulatory and morphogenic signalling pathways. Mol Microbiol. 2009;74:1272-86 pubmed publisher
    ..developments including the above characteristics as well as AQY2 expression through the osmoregulatory Hog1 mitogen-activated protein kinase...
  13. Zi Z, Liebermeister W, Klipp E. A quantitative study of the Hog1 MAPK response to fluctuating osmotic stress in Saccharomyces cerevisiae. PLoS ONE. 2010;5:e9522 pubmed publisher
    ..The Hog1 mitogen-activated protein kinase (MAPK) pathway is crucial for the adaption of yeast cells to external osmotic ..
  14. Posas F, Wurgler Murphy S, Maeda T, Witten E, Thai T, Saito H. Yeast HOG1 MAP kinase cascade is regulated by a multistep phosphorelay mechanism in the SLN1-YPD1-SSK1 "two-component" osmosensor. Cell. 1996;86:865-75 pubmed
    ..We propose that the multistep phosphorelay mechanism is a universal signal transduction apparatus utilized both in prokaryotes and eukaryotes. ..
  15. Hao N, Zeng Y, Elston T, Dohlman H. Control of MAPK specificity by feedback phosphorylation of shared adaptor protein Ste50. J Biol Chem. 2008;283:33798-802 pubmed publisher
    ..Although Kss1 activity is sustained and promotes invasive growth, Hog1 activity is transient and promotes cell adaptation to osmotic stress...
  16. Escote X, Zapater M, Clotet J, Posas F. Hog1 mediates cell-cycle arrest in G1 phase by the dual targeting of Sic1. Nat Cell Biol. 2004;6:997-1002 pubmed
    ..The exposure of yeast cells to high osmolarity, or mutations that lead to activation of the Hog1 SAPK, result in cell-cycle arrest...
  17. Cook K, O Shea E. Hog1 controls global reallocation of RNA Pol II upon osmotic shock in Saccharomyces cerevisiae. G3 (Bethesda). 2012;2:1129-36 pubmed publisher
    ..The stress-responsive MAP kinase Hog1 activates expression of specific genes through interactions with chromatin remodeling enzymes, transcription ..
  18. Adrover M, Zi Z, Duch A, Schaber J, Gonzalez Novo A, Jimenez J, et al. Time-dependent quantitative multicomponent control of the G?-S network by the stress-activated protein kinase Hog1 upon osmostress. Sci Signal. 2011;4:ra63 pubmed publisher
    ..Exposure of yeast to hyperosmotic stress activates the SAPK Hog1, which delays cell cycle progression through G? by direct phosphorylation of the cyclin-dependent kinase (CDK) ..
  19. Geijer C, Medrala Klein D, Petelenz Kurdziel E, Ericsson A, Smedh M, Andersson M, et al. Initiation of the transcriptional response to hyperosmotic shock correlates with the potential for volume recovery. FEBS J. 2013;280:3854-67 pubmed publisher
    ..We employed a conditional osmotic system, which changes the period of the MAPK Hog1 signal independent of the initial stress level...
  20. O Rourke S, Herskowitz I. The Hog1 MAPK prevents cross talk between the HOG and pheromone response MAPK pathways in Saccharomyces cerevisiae. Genes Dev. 1998;12:2874-86 pubmed
    ..We found that mutations in the HOG1 gene, encoding the p38-type MAPK of the HOG pathway, and in the PBS2 gene, encoding the activating kinase for Hog1p,..
  21. Hao N, Behar M, Parnell S, Torres M, Borchers C, Elston T, et al. A systems-biology analysis of feedback inhibition in the Sho1 osmotic-stress-response pathway. Curr Biol. 2007;17:659-67 pubmed
    ..For instance in yeast, the mitogen-activated protein (MAP) kinase Hog1 is activated and inactivated within minutes, even when the osmotic-stress stimulus is sustained...
  22. Ruiz Roig C, Noriega N, Duch A, Posas F, de Nadal E. The Hog1 SAPK controls the Rtg1/Rtg3 transcriptional complex activity by multiple regulatory mechanisms. Mol Biol Cell. 2012;23:4286-96 pubmed publisher
    ..Exposure of yeast to external hyperosmolarity activates the Hog1 stress-activated protein kinase (SAPK), which is a key player in the regulation of gene expression upon stress...
  23. Bilsland Marchesan E, Arino J, Saito H, Sunnerhagen P, Posas F. Rck2 kinase is a substrate for the osmotic stress-activated mitogen-activated protein kinase Hog1. Mol Cell Biol. 2000;20:3887-95 pubmed
    Exposure of yeast cells to increases in extracellular osmolarity activates the Hog1 mitogen-activated protein kinase (MAPK)...
  24. Rep M, Reiser V, Gartner U, Thevelein J, Hohmann S, Ammerer G, et al. Osmotic stress-induced gene expression in Saccharomyces cerevisiae requires Msn1p and the novel nuclear factor Hot1p. Mol Cell Biol. 1999;19:5474-85 pubmed
    ..Thus, Hot1p and Msn1p may define an additional tier of transcriptional regulators that control responses to high-osmolarity stress. ..
  25. Mettetal J, Muzzey D, Gomez Uribe C, van Oudenaarden A. The frequency dependence of osmo-adaptation in Saccharomyces cerevisiae. Science. 2008;319:482-4 pubmed publisher
    ..the dynamics of the osmo-adaptation response are dominated by a fast-acting negative feedback through the kinase Hog1 that does not require protein synthesis...
  26. Alepuz P, de Nadal E, Zapater M, Ammerer G, Posas F. Osmostress-induced transcription by Hot1 depends on a Hog1-mediated recruitment of the RNA Pol II. EMBO J. 2003;22:2433-42 pubmed
    In budding yeast, the mitogen-activated protein kinase (MAPK) Hog1 coordinates the transcriptional program required for cell survival upon osmostress...
  27. Bicknell A, Tourtellotte J, Niwa M. Late phase of the endoplasmic reticulum stress response pathway is regulated by Hog1 MAP kinase. J Biol Chem. 2010;285:17545-55 pubmed publisher
    ..We show that Hog1 MAP kinase becomes phosphorylated during the late stage of ER stress and helps the ER regain homeostasis...
  28. Vendrell A, Martínez Pastor M, Gonzalez Novo A, Pascual Ahuir A, Sinclair D, Proft M, et al. Sir2 histone deacetylase prevents programmed cell death caused by sustained activation of the Hog1 stress-activated protein kinase. EMBO Rep. 2011;12:1062-8 pubmed publisher
    Exposure of yeast to high osmolarity induces a transient activation of the Hog1 stress-activated protein kinase (SAPK), which is required for cell survival under these conditions...
  29. Regot S, de Nadal E, Rodriguez Navarro S, Gonzalez Novo A, Pérez Fernández J, Gadal O, et al. The Hog1 stress-activated protein kinase targets nucleoporins to control mRNA export upon stress. J Biol Chem. 2013;288:17384-98 pubmed publisher
    ..In yeast, the Hog1 SAPK plays a key role in reprogramming the gene expression pattern required for cell survival upon osmostress by ..
  30. de Nadal E, Zapater M, Alepuz P, Sumoy L, Mas G, Posas F. The MAPK Hog1 recruits Rpd3 histone deacetylase to activate osmoresponsive genes. Nature. 2004;427:370-4 pubmed
    ..Exposure of yeast cells to high osmolarity results in rapid activation of the MAPK Hog1, which coordinates the transcriptional programme required for cell survival on osmostress...
  31. Capaldi A, Kaplan T, Liu Y, Habib N, Regev A, Friedman N, et al. Structure and function of a transcriptional network activated by the MAPK Hog1. Nat Genet. 2008;40:1300-6 pubmed publisher
    ..networks, we analyzed gene expression in single- and multiple-mutant strains to build a quantitative model of the Hog1 MAPK-dependent osmotic stress response in budding yeast...
  32. Siderius M, Van Wuytswinkel O, Reijenga K, Kelders M, Mager W. The control of intracellular glycerol in Saccharomyces cerevisiae influences osmotic stress response and resistance to increased temperature. Mol Microbiol. 2000;36:1381-90 pubmed
    ..A hog1 deletion strain was previously found to contain lower internal glycerol and therefore displays an osmosensitive ..
  33. Westfall P, Patterson J, Chen R, Thorner J. Stress resistance and signal fidelity independent of nuclear MAPK function. Proc Natl Acad Sci U S A. 2008;105:12212-7 pubmed publisher
    ..The yeast high-osmolarity glycerol (HOG) pathway activates Hog1 MAPK (mammalian ortholog p38alpha/SAPKalpha), which enters the nucleus and induces expression of >50 genes, ..
  34. Proft M, Struhl K. MAP kinase-mediated stress relief that precedes and regulates the timing of transcriptional induction. Cell. 2004;118:351-61 pubmed
    ..Osmotic stress activates Hog1 MAP kinase, which phosphorylates at least two proteins located at the plasma membrane, the Nha1 Na+/H+ antiporter ..
  35. Kobayashi Y, Inai T, Mizunuma M, Okada I, Shitamukai A, Hirata D, et al. Identification of Tup1 and Cyc8 mutations defective in the responses to osmotic stress. Biochem Biophys Res Commun. 2008;368:50-5 pubmed publisher
  36. Jacoby T, Flanagan H, Faykin A, Seto A, Mattison C, Ota I. Two protein-tyrosine phosphatases inactivate the osmotic stress response pathway in yeast by targeting the mitogen-activated protein kinase, Hog1. J Biol Chem. 1997;272:17749-55 pubmed
    ..The substrate of these phosphatases is likely to be the MAPK, Hog1. Catalytically inactive Ptp2 and Ptp3 coprecipitate with Hog1 from yeast extracts...
  37. Proft M, Pascual Ahuir A, de Nadal E, Arino J, Serrano R, Posas F. Regulation of the Sko1 transcriptional repressor by the Hog1 MAP kinase in response to osmotic stress. EMBO J. 2001;20:1123-33 pubmed
    Exposure of yeast to increases in extracellular osmolarity activates the Hog1 mitogen-activated protein kinase (MAPK), which is essential for the induction of gene expression required for cell survival upon osmotic stress...
  38. Yaakov G, Duch A, Garcia Rubio M, Clotet J, Jimenez J, Aguilera A, et al. The stress-activated protein kinase Hog1 mediates S phase delay in response to osmostress. Mol Biol Cell. 2009;20:3572-82 pubmed publisher
    ..Exposure of yeast to osmostress activates the Hog1 SAPK, which modulates cell cycle progression at G1 and G2 by the phosphorylation of elements of the cell cycle ..
  39. Zapater M, Sohrmann M, Peter M, Posas F, de Nadal E. Selective requirement for SAGA in Hog1-mediated gene expression depending on the severity of the external osmostress conditions. Mol Cell Biol. 2007;27:3900-10 pubmed
    Regulation of gene expression by the Hog1 stress-activated protein kinase is essential for proper cell adaptation to osmostress. Hog1 coordinates an extensive transcriptional program through the modulation of transcription...
  40. Ferrigno P, Posas F, Koepp D, Saito H, Silver P. Regulated nucleo/cytoplasmic exchange of HOG1 MAPK requires the importin beta homologs NMD5 and XPO1. EMBO J. 1998;17:5606-14 pubmed
    ..Exposure of yeast cells to increases in extracellular osmolarity activates the HOG1 MAP kinase cascade, which is composed of three tiers of protein kinases, namely the SSK2, SSK22 and STE11 MAPKKKs, ..
  41. Thorsen M, Di Y, Tängemo C, Morillas M, Ahmadpour D, Van der Does C, et al. The MAPK Hog1p modulates Fps1p-dependent arsenite uptake and tolerance in yeast. Mol Biol Cell. 2006;17:4400-10 pubmed
    ..Understanding how arsenite/antimonite uptake and toxicity is modulated may prove of value for their use in medical therapy. ..
  42. Lee J, Reiter W, Dohnal I, Gregori C, Beese Sims S, Kuchler K, et al. MAPK Hog1 closes the S. cerevisiae glycerol channel Fps1 by phosphorylating and displacing its positive regulators. Genes Dev. 2013;27:2590-601 pubmed publisher
    ..shock involves a redundant pair of regulators, Rgc1 (regulator of the glycerol channel 1) and Rgc2, and the MAPK Hog1 (high-osmolarity glycerol response 1)...
  43. Clotet J, Escote X, Adrover M, Yaakov G, Garí E, Aldea M, et al. Phosphorylation of Hsl1 by Hog1 leads to a G2 arrest essential for cell survival at high osmolarity. EMBO J. 2006;25:2338-46 pubmed
    ..Exposure of yeast to osmostress leads to activation of the Hog1 SAPK, which controls cell cycle at G1 by the targeting of Sic1...
  44. Westfall P, Thorner J. Analysis of mitogen-activated protein kinase signaling specificity in response to hyperosmotic stress: use of an analog-sensitive HOG1 allele. Eukaryot Cell. 2006;5:1215-28 pubmed
    ..This loss of signaling specificity is known as cross talk. To determine whether it is the Hog1 polypeptide per se or its kinase activity that is necessary to prevent cross talk, we constructed a fully ..
  45. Kim S, Shah K. Dissecting yeast Hog1 MAP kinase pathway using a chemical genetic approach. FEBS Lett. 2007;581:1209-16 pubmed
    Using a chemical genetic approach, we identified four novel physiological substrates of Hog1 kinase (Krs1, Tdh3, Hsp26, and Shm2)...
  46. Teixeira V, Medeiros T, Vilaça R, Pereira A, Chaves S, Côrte Real M, et al. Ceramide signalling impinges on Sit4p and Hog1p to promote mitochondrial fission and mitophagy in Isc1p-deficient cells. Cell Signal. 2015;27:1840-9 pubmed publisher
  47. Lee S, Park S, Na J, Kim Y. Osmolarity hypersensitivity of hog1 deleted mutants is suppressed by mutation in KSS1 in budding yeast Saccharomyces cerevisiae. FEMS Microbiol Lett. 2002;209:9-14 pubmed
    ..This study aimed to investigate the response of the yeast to osmotic stress. A mutant strain, in which the HOG1 gene was disrupted by TRP1, was constructed...
  48. Escote X, Miranda M, Rodríguez Porrata B, Mas A, Cordero R, Posas F, et al. The stress-activated protein kinase Hog1 develops a critical role after resting state. Mol Microbiol. 2011;80:423-35 pubmed publisher
    ..Similar results are obtained in higher eukaryotic cells by activation of p38. Thus, these results reveal a novel role of the SAPK Hog1p in the control of cell cycle progression as cells leave a resting state. ..
  49. Yamamoto K, Tatebayashi K, Tanaka K, Saito H. Dynamic control of yeast MAP kinase network by induced association and dissociation between the Ste50 scaffold and the Opy2 membrane anchor. Mol Cell. 2010;40:87-98 pubmed publisher
    ..CR-A binds Ste50 constitutively and can transmit signals to both the Hog1 and Fus3/Kss1 MAPKs...
  50. Mollapour M, Shepherd A, Piper P. Presence of the Fps1p aquaglyceroporin channel is essential for Hog1p activation, but suppresses Slt2(Mpk1)p activation, with acetic acid stress of yeast. Microbiology. 2009;155:3304-11 pubmed publisher
    ..Lack of Fps1p therefore exerts opposing effects on the activation of Hog1p and Slt2p in yeast exposed to acetic acid stress. ..
  51. Montañés F, Pascual Ahuir A, Proft M. Repression of ergosterol biosynthesis is essential for stress resistance and is mediated by the Hog1 MAP kinase and the Mot3 and Rox1 transcription factors. Mol Microbiol. 2011;79:1008-23 pubmed publisher
    Hyperosmotic stress triggers a complex adaptive response that is dominantly regulated by the Hog1 MAP kinase in yeast...
  52. Abu Irqeba A, Li Y, Panahi M, Zhu M, Wang Y. Regulating global sumoylation by a MAP kinase Hog1 and its potential role in osmo-tolerance in yeast. PLoS ONE. 2014;9:e87306 pubmed publisher
    ..Interestingly, disruption of MAP kinase Hog1 leads to a much higher level of accumulation of sumoylated conjugates that are independent of new protein synthesis...
  53. Romero Santacreu L, Orozco H, Garre E, Alepuz P. The bidirectional cytomegalovirus immediate/early promoter is regulated by Hog1 and the stress transcription factors Sko1 and Hot1 in yeast. Mol Genet Genomics. 2010;283:511-8 pubmed publisher
    ..The mitogen-activated protein (MAP) kinase Hog1 controls CMV activation by osmotic stress through the ATF/CRE-related transcription factor Sko1 and the yeast ..
  54. Nevitt T, Pereira J, Azevedo D, Guerreiro P, Rodrigues Pousada C. Expression of YAP4 in Saccharomyces cerevisiae under osmotic stress. Biochem J. 2004;379:367-74 pubmed
    ..4 M and 0.8 M NaCl respectively, a fact that led us to analyse YAP4 mRNA levels in the hog1 (high osmolarity glycerol) mutant...
  55. Eraso P, Mazón M, Posas F, Portillo F. Gene expression profiling of yeasts overexpressing wild type or misfolded Pma1 variants reveals activation of the Hog1 MAPK pathway. Mol Microbiol. 2011;79:1339-52 pubmed publisher
    ..The results suggest that the high osmolarity glycerol (Hog1) mitogen-activated protein kinase (MAPK) pathway is activated by both wild type and mutant ATPases...
  56. Cherkasova V, Lyons D, Elion E. Fus3p and Kss1p control G1 arrest in Saccharomyces cerevisiae through a balance of distinct arrest and proliferative functions that operate in parallel with Far1p. Genetics. 1999;151:989-1004 pubmed
    ..Thus, Fus3p and Kss1p control G1 arrest through a balance of arrest functions that inhibit the Cdc28p machinery and proliferative functions that bypass this inhibition. ..
  57. Mizunuma M, Ogawa T, Koyama T, Shitamukai A, Tsubakiyama R, Komaruyama T, et al. Evidence of antagonistic regulation of restart from G(1) delay in response to osmotic stress by the Hog1 and Whi3 in budding yeast. Biosci Biotechnol Biochem. 2013;77:2002-7 pubmed
    b>Hog1 of Saccharomyces cerevisiae is activated by hyperosmotic stress, and this leads to cell-cycle delay in G1, but the mechanism by which cells restart from G1 delay remains elusive...
  58. Motizuki M, Yokota S, Tsurugi K. Effect of low pH on organization of the actin cytoskeleton in Saccharomyces cerevisiae. Biochim Biophys Acta. 2008;1780:179-84 pubmed
    ..distribution of actin in response to low pH conditions, focusing on the role of mitogen-activated protein kinases, Hog1 and Slt2. Changing the extracellular pH from 6.0 to 3.0 caused a transient depolarization of the actin cytoskeleton...
  59. Pigula A, Drubin D, Barnes G. Regulation of mitotic spindle disassembly by an environmental stress-sensing pathway in budding yeast. Genetics. 2014;198:1043-57 pubmed publisher
    ..three genes in the environmental stress-sensing HOG (high-osmolarity glycerol response) pathway, SHO1, PBS2, and HOG1, and found they are necessary for proper localization of She1 to the anaphase spindle and for proper spindle ..
  60. Sharifian H, Lampert F, Stojanovski K, Regot S, Vaga S, Buser R, et al. Parallel feedback loops control the basal activity of the HOG MAPK signaling cascade. Integr Biol (Camb). 2015;7:412-22 pubmed publisher
    Tight regulation of the MAP kinase Hog1 is crucial for survival under changing osmotic conditions. Interestingly, we found that Hog1 phosphorylates multiple upstream components, implying feedback regulation within the signaling cascade...
  61. Murakami Y, Tatebayashi K, Saito H. Two adjacent docking sites in the yeast Hog1 mitogen-activated protein (MAP) kinase differentially interact with the Pbs2 MAP kinase kinase and the Ptp2 protein tyrosine phosphatase. Mol Cell Biol. 2008;28:2481-94 pubmed publisher
    ..Here, we investigated the mechanism by which the yeast osmoregulatory Hog1 MAPK specifically interacts with its activator, the MAPK kinase Pbs2, and its major inactivator, the protein ..