HMO1

Summary

Gene Symbol: HMO1
Description: Hmo1p
Alias: HSM2, Hmo1p
Species: Saccharomyces cerevisiae S288c
Products:     HMO1

Top Publications

  1. Beckouët F, Labarre Mariotte S, Albert B, Imazawa Y, Werner M, Gadal O, et al. Two RNA polymerase I subunits control the binding and release of Rrn3 during transcription. Mol Cell Biol. 2008;28:1596-605 pubmed
    ..These data suggest a dual role of the Rpa49-Rpa34 dimer during the recruitment of Rrn3 and its subsequent dissociation from the elongating polymerase. ..
  2. Hall D, Wade J, Struhl K. An HMG protein, Hmo1, associates with promoters of many ribosomal protein genes and throughout the rRNA gene locus in Saccharomyces cerevisiae. Mol Cell Biol. 2006;26:3672-9 pubmed
    ..Saccharomyces cerevisiae encodes 10 HMG proteins, including Hmo1, which is important for maximal transcription of rRNA...
  3. Merz K, Hondele M, Goetze H, Gmelch K, Stoeckl U, Griesenbeck J. Actively transcribed rRNA genes in S. cerevisiae are organized in a specialized chromatin associated with the high-mobility group protein Hmo1 and are largely devoid of histone molecules. Genes Dev. 2008;22:1190-204 pubmed publisher
    ..We demonstrate that actively transcribed rRNA genes are largely devoid of histone molecules, but instead associate with the high-mobility group protein Hmo1.
  4. Kamau E, Bauerle K, Grove A. The Saccharomyces cerevisiae high mobility group box protein HMO1 contains two functional DNA binding domains. J Biol Chem. 2004;279:55234-40 pubmed
    ..b>HMO1 is one of 10 Saccharomyces cerevisiae HMGB proteins, and it is required for normal growth and plasmid maintenance ..
  5. Kasahara K, Ohtsuki K, Ki S, Aoyama K, Takahashi H, Kobayashi T, et al. Assembly of regulatory factors on rRNA and ribosomal protein genes in Saccharomyces cerevisiae. Mol Cell Biol. 2007;27:6686-705 pubmed
    b>HMO1 is a high-mobility group B protein that plays a role in transcription of genes encoding rRNA and ribosomal proteins (RPGs) in Saccharomyces cerevisiae...
  6. Lu J, Kobayashi R, Brill S. Characterization of a high mobility group 1/2 homolog in yeast. J Biol Chem. 1996;271:33678-85 pubmed
    ..Amino acid sequence alignment suggests that this protein, Hmo1p, is related to the HMG1/2 class of chromatin-associated proteins...
  7. Bauerle K, Kamau E, Grove A. Interactions between N- and C-terminal domains of the Saccharomyces cerevisiae high-mobility group protein HMO1 are required for DNA bending. Biochemistry. 2006;45:3635-45 pubmed
    The Saccharomyces cerevisiae high-mobility group protein HMO1 is composed of two DNA-binding domains termed box A and box B, of which only box B is predicted to adopt a HMG fold, and a lysine-rich C-terminal extension...
  8. Albert B, Colleran C, L ger Silvestre I, Berger A, Dez C, Normand C, et al. Structure-function analysis of Hmo1 unveils an ancestral organization of HMG-Box factors involved in ribosomal DNA transcription from yeast to human. Nucleic Acids Res. 2013;41:10135-49 pubmed publisher
    Ribosome biogenesis is a major metabolic effort for growing cells. In Saccharomyces cerevisiae, Hmo1, an abundant high-mobility group box protein (HMGB) binds to the coding region of the RNA polymerase I transcribed ribosomal RNAs genes ..
  9. Gonzalez Huici V, Szakal B, Urulangodi M, Psakhye I, Castellucci F, Menolfi D, et al. DNA bending facilitates the error-free DNA damage tolerance pathway and upholds genome integrity. EMBO J. 2014;33:327-40 pubmed publisher
    ..Here we show that a chromatin architectural pathway involving the high mobility group box protein Hmo1 channels replication-associated lesions into the error-free DNA damage tolerance pathway mediated by Rad5 and PCNA ..

More Information

Publications35

  1. Xiao L, Kamau E, Donze D, Grove A. Expression of yeast high mobility group protein HMO1 is regulated by TOR signaling. Gene. 2011;489:55-62 pubmed publisher
    ..this regulation, and its localization to ribosomal protein gene promoters requires the high mobility group protein HMO1. We show here that HMO1 expression is similarly controlled by TOR signaling...
  2. Alekseev S, Kovaltsova S, Fedorova I, Gracheva L, Evstukhina T, Peshekhonov V, et al. HSM2 (HMO1) gene participates in mutagenesis control in yeast Saccharomyces cerevisiae. DNA Repair (Amst). 2002;1:287-97 pubmed
    ..Now HSM2 gene has been genetically and physically mapped and identified as a gene previously characterized as HMO1, a yeast homologue of human high mobility group genes HMG1/2...
  3. Xiao L, Williams A, Grove A. The C-terminal domain of yeast high mobility group protein HMO1 mediates lateral protein accretion and in-phase DNA bending. Biochemistry. 2010;49:4051-9 pubmed publisher
    The Saccharomyces cerevisiae high mobility group protein HMO1 has two DNA binding domains, box A and box B, and a lysine-rich C-terminal extension...
  4. Bermejo R, Capra T, Gonzalez Huici V, Fachinetti D, Cocito A, Natoli G, et al. Genome-organizing factors Top2 and Hmo1 prevent chromosome fragility at sites of S phase transcription. Cell. 2009;138:870-84 pubmed publisher
    ..These intergenic loci associate with the HMG protein Hmo1 throughout the cell cycle and are refractory to the histone variant Htz1...
  5. Gadal O, Labarre S, Boschiero C, Thuriaux P. Hmo1, an HMG-box protein, belongs to the yeast ribosomal DNA transcription system. EMBO J. 2002;21:5498-507 pubmed
    b>Hmo1 is one of seven HMG-box proteins of Saccharo myces cerevisiae. Null mutants have a limited effect on growth...
  6. Kim H, Livingston D. Suppression of a DNA polymerase delta mutation by the absence of the high mobility group protein Hmo1 in Saccharomyces cerevisiae. Curr Genet. 2009;55:127-38 pubmed publisher
    The deletion of the gene encoding the high mobility group protein Hmo1 suppresses the growth retardation of the DNA pol delta mutation, pol3-14, at the restrictive temperature...
  7. Kasahara K, Ki S, Aoyama K, Takahashi H, Kokubo T. Saccharomyces cerevisiae HMO1 interacts with TFIID and participates in start site selection by RNA polymerase II. Nucleic Acids Res. 2008;36:1343-57 pubmed publisher
    Saccharomyces cerevisiae HMO1, a high mobility group B (HMGB) protein, associates with the rRNA locus and with the promoters of many ribosomal protein genes (RPGs)...
  8. Panday A, Grove A. Yeast HMO1: Linker Histone Reinvented. Microbiol Mol Biol Rev. 2017;81: pubmed
    ..Here, we discuss the functions of S. cerevisiae HMO1, an HMGB family protein unique in containing a terminal lysine-rich domain and in stabilizing genomic DNA...
  9. Panday A, Gupta A, Srinivasa K, Xiao L, Smith M, Grove A. DNA damage regulates direct association of TOR kinase with the RNA polymerase II-transcribed HMO1 gene. Mol Biol Cell. 2017;28:2449-2459 pubmed publisher
    ..The Saccharomyces cerevisiae high-mobility group protein Hmo1p has been implicated in coordinating this response to mTORC1 inhibition...
  10. Sampath V, Liu B, Tafrov S, Srinivasan M, Rieger R, Chen E, et al. Biochemical characterization of Hpa2 and Hpa3, two small closely related acetyltransferases from Saccharomyces cerevisiae. J Biol Chem. 2013;288:21506-13 pubmed publisher
    ..These results suggest that Hpa2 and Hpa3 are similar but distinct acetyltransferases that might have overlapping roles with other known acetyltransferases in vivo in acetylating histones and other small proteins. ..
  11. Murugesapillai D, McCauley M, Huo R, Nelson Holte M, Stepanyants A, Maher L, et al. DNA bridging and looping by HMO1 provides a mechanism for stabilizing nucleosome-free chromatin. Nucleic Acids Res. 2014;42:8996-9004 pubmed publisher
    ..It is not understood how these factors control the interplay between genome accessibility and compaction. In vivo, HMO1 binds the promoter and coding regions of most ribosomal RNA genes, facilitating transcription and possibly ..
  12. Higashino A, Shiwa Y, Yoshikawa H, Kokubo T, Kasahara K. Both HMG boxes in Hmo1 are essential for DNA binding in vitro and in vivo. Biosci Biotechnol Biochem. 2015;79:384-93 pubmed publisher
    b>Hmo1, a member of the high mobility group B family proteins in Saccharomyces cerevisiae, associates with the promoters of ribosomal protein genes (RPGs) to direct accurate transcriptional initiation...
  13. Kasahara K, Higashino A, Unzai S, Yoshikawa H, Kokubo T. Oligomerization of Hmo1 mediated by box A is essential for DNA binding in vitro and in vivo. Genes Cells. 2016;21:1333-1352 pubmed publisher
    b>Hmo1, a member of HMGB family proteins in Saccharomyces cerevisiae, binds to and regulates the transcription of genes encoding ribosomal RNA and ribosomal proteins...
  14. Koval tsova S, Gracheva L, Evstiukhina T, Fedorova I, Alekseev S, Korolev V. [Mutator genes of the yeast Saccharomyces cerevisiae. Interaction of mutations him and his with mutations blocking three principal pathways of repair of induced DNA damage]. Genetika. 1996;32:1061-7 pubmed
    ..On the other hand, mutation rad2 synergistically interacts with mutations him1, hsm1, hsm3, hsm6, and hsm2, thus enhancing the frequency of UV-induced mutagenesis in double mutants multiple times...
  15. Fedorov D, Koval tsova S, Peshekhonov V, Korolev V. [IXR1 and HMO1 genes jointly control the level of spontaneous mutagenesis in yeast Saccharomyces cerevisiae]. Genetika. 2010;46:750-7 pubmed
    The yeast genes IXR1 and HMO1 encode proteins belonging to the family of chromatin nonhistone proteins, which are able to recognize and bind to irregular DNA structures...
  16. Joo Y, Kim J, Baek J, Seong K, Lee J, Kim J. Determination of the core promoter regions of the Saccharomyces cerevisiae RPS3 gene. Biochim Biophys Acta. 2009;1789:741-50 pubmed publisher
    ..Taken together, our results further the current understanding of the promoter architecture and trans-elements of the Saccharomyces cerevisiae RPS3 gene. ..
  17. Sinha H, David L, Pascon R, Clauder Münster S, Krishnakumar S, Nguyen M, et al. Sequential elimination of major-effect contributors identifies additional quantitative trait loci conditioning high-temperature growth in yeast. Genetics. 2008;180:1661-70 pubmed publisher
    ..The targeted backcrossing approach overcomes the difficulties posed by sample size, genetic linkage, and epistatic effects and facilitates identification of additional alleles with smaller contributions to complex traits. ..
  18. Dolinski K, Heitman J. Hmo1p, a high mobility group 1/2 homolog, genetically and physically interacts with the yeast FKBP12 prolyl isomerase. Genetics. 1999;151:935-44 pubmed
    ..In addition, Hmo1p and FKBP12 physically interact in FKBP12 affinity chromatography experiments, and two-hybrid experiments suggest ..
  19. Kagansky A, Freeman L, Lukyanov D, Strunnikov A. Histone tail-independent chromatin binding activity of recombinant cohesin holocomplex. J Biol Chem. 2004;279:3382-8 pubmed
    ..Histone tails and ATP are dispensable for cohesin binding to chromatin in this reaction. A model for cohesin association with chromatin is proposed. ..
  20. Panday A, Grove A. The high mobility group protein HMO1 functions as a linker histone in yeast. Epigenetics Chromatin. 2016;9:13 pubmed publisher
    ..In contrast, the yeast high mobility group (HMGB) protein HMO1 has been reported to compact chromatin, as evidenced by increased nuclease sensitivity in hmo1? cells...
  21. Kasahara K, Ohyama Y, Kokubo T. Hmo1 directs pre-initiation complex assembly to an appropriate site on its target gene promoters by masking a nucleosome-free region. Nucleic Acids Res. 2011;39:4136-50 pubmed publisher
    Saccharomyces cerevisiae Hmo1 binds to the promoters of ? 70% of ribosomal protein genes (RPGs) at high occupancy, but is observed at lower occupancy on the remaining RPG promoters...
  22. Chen H, Fan M, Pfeffer L, Laribee R. The histone H3 lysine 56 acetylation pathway is regulated by target of rapamycin (TOR) signaling and functions directly in ribosomal RNA biogenesis. Nucleic Acids Res. 2012;40:6534-46 pubmed publisher
    ..RNA polymerase I transcription and nascent rRNA processing by regulating binding of the high mobility group protein Hmo1 and the small ribosomal subunit (SSU) processome complex...
  23. Panday A, Xiao L, Grove A. Yeast high mobility group protein HMO1 stabilizes chromatin and is evicted during repair of DNA double strand breaks. Nucleic Acids Res. 2015;43:5759-70 pubmed publisher
    ..Chromatin remodeling overcomes this barrier. We show here that the Saccharomyces cerevisiae HMGB protein HMO1 stabilizes chromatin as evidenced by faster chromatin remodeling in its absence...
  24. Panday A, Xiao L, Gupta A, Grove A. Control of DNA end resection by yeast Hmo1p affects efficiency of DNA end-joining. DNA Repair (Amst). 2017;53:15-23 pubmed publisher
    ..In Saccharomyces cerevisiae, the high mobility group protein Hmo1p has been implicated in controlling DNA end resection, suggesting its potential role in repair pathway choice...
  25. Kelberg E, Kovaltsova S, Alekseev S, Fedorova I, Gracheva L, Evstukhina T, et al. HIM1, a new yeast Saccharomyces cerevisiae gene playing a role in control of spontaneous and induced mutagenesis. Mutat Res. 2005;578:64-78 pubmed
    ..repair; rad2, rev3, and rad54, blocking three principal DNA repair pathways; pms1, blocking mismatch repair; hsm2 and hsm3 mutations, which lead to a mutator effect...
  26. Hepp M, Smolle M, Gidi C, Amigo R, Valenzuela N, Arriagada A, et al. Role of Nhp6 and Hmo1 in SWI/SNF occupancy and nucleosome landscape at gene regulatory regions. Biochim Biophys Acta Gene Regul Mech. 2017;1860:316-326 pubmed publisher
    ..In this context, we have previously demonstrated that the yeast HMG proteins Nhp6 and Hmo1 can stimulate SWI/SNF activity...