HIR3

Summary

Gene Symbol: HIR3
Description: Hir3p
Alias: HPC1, Hir3p
Species: Saccharomyces cerevisiae S288c
Products:     HIR3

Top Publications

  1. Prochasson P, Florens L, Swanson S, Washburn M, Workman J. The HIR corepressor complex binds to nucleosomes generating a distinct protein/DNA complex resistant to remodeling by SWI/SNF. Genes Dev. 2005;19:2534-9 pubmed
    ..Here, we demonstrate that Hir1, Hir2, Hir3, and Hpc2 proteins form a stable HIR repressor complex...
  2. Xu H, Kim U, Schuster T, Grunstein M. Identification of a new set of cell cycle-regulatory genes that regulate S-phase transcription of histone genes in Saccharomyces cerevisiae. Mol Cell Biol. 1992;12:5249-59 pubmed
    ..Using this approach, we have isolated five mutants (hpc1, hpc2, hpc3, hpc4, and hpc5) in which cell cycle regulation of histone gene transcription is altered...
  3. Spector M, Raff A, deSilva H, Lee K, Osley M. Hir1p and Hir2p function as transcriptional corepressors to regulate histone gene transcription in the Saccharomyces cerevisiae cell cycle. Mol Cell Biol. 1997;17:545-52 pubmed
    ..The two proteins might function as a complex in vivo: Hir2p required both Hir1p and another Hir protein, Hir3p, to repress transcription when it was tethered to an HTA1-lacZ reporter gene, and Hir1p and Hir2p could be ..
  4. Formosa T, Ruone S, Adams M, Olsen A, Eriksson P, Yu Y, et al. Defects in SPT16 or POB3 (yFACT) in Saccharomyces cerevisiae cause dependence on the Hir/Hpc pathway: polymerase passage may degrade chromatin structure. Genetics. 2002;162:1557-71 pubmed
    ..when combined with a mutation in any member of the set of functionally related genes HIR1, HIR2/SPT1, HIR3/HPC1, or HPC2. Mutations in POB3, but not in NHP6A/B, also display strong synthetic defects with hir/hpc mutations...
  5. Green E, Antczak A, Bailey A, Franco A, Wu K, Yates J, et al. Replication-independent histone deposition by the HIR complex and Asf1. Curr Biol. 2005;15:2044-9 pubmed
    ..Here, we demonstrate that Hir1, Hir2, Hir3, and Hpc2 comprise the HIR complex, which copurifies with the histone deposition protein Asf1...
  6. Pham H, Ferrari R, Cokus S, Kurdistani S, Pellegrini M. Modeling the regulatory network of histone acetylation in Saccharomyces cerevisiae. Mol Syst Biol. 2007;3:153 pubmed
    ..We validate the model, both computationally and experimentally, to demonstrate that it yields accurate predictions of these regulatory mechanisms. ..
  7. Lin L, Minard L, Johnston G, Singer R, Schultz M. Asf1 can promote trimethylation of H3 K36 by Set2. Mol Cell Biol. 2010;30:1116-29 pubmed publisher
    ..This function of Asf1 promotes the switch from di- to trimethylation of H3 K36 at that gene. These results support the view that Set2 function in chromatin metabolism can intimately involve histone chaperone Asf1. ..
  8. Qian Z, Huang H, Hong J, Burck C, Johnston S, Berman J, et al. Yeast Ty1 retrotransposition is stimulated by a synergistic interaction between mutations in chromatin assembly factor I and histone regulatory proteins. Mol Cell Biol. 1998;18:4783-92 pubmed
    ..CAC3 gene in the strain in which this screen was undertaken enabled us to discover that double mutaions of cac3 and hir3, but neither of the two single mutations, caused a dramatic increase in the rate of retrotransposition...
  9. Huang H, Hong J, Burck C, Liebman S. Host genes that affect the target-site distribution of the yeast retrotransposon Ty1. Genetics. 1999;151:1393-407 pubmed
    ..We found that the simultaneous inactivation of Hir3 (a histone transcription regulator) and Cac3 (a subunit of the chromatin assembly factor I), which was previously ..

More Information

Publications13

  1. Nourani A, Robert F, Winston F. Evidence that Spt2/Sin1, an HMG-like factor, plays roles in transcription elongation, chromatin structure, and genome stability in Saccharomyces cerevisiae. Mol Cell Biol. 2006;26:1496-509 pubmed
    ..Taken together, our results suggest a direct link for Spt2 with transcription elongation, chromatin dynamics, and genome stability. ..
  2. Vishnoi N, Flaherty K, Hancock L, Ferreira M, Amin A, Prochasson P. Separation-of-function mutation in HPC2, a member of the HIR complex in S. cerevisiae, results in derepression of the histone genes but does not confer cryptic TATA phenotypes. Biochim Biophys Acta. 2011;1809:557-66 pubmed publisher
    The HIR complex, which is comprised of the four proteins Hir1, Hir2, Hir3 and Hpc2, was first characterized as a repressor of three of the four histone gene loci in Saccharomyces cerevisiae...
  3. Georgakopoulos T, Koutroubas G, Vakonakis I, Tzermia M, Prokova V, Voutsina A, et al. Functional analysis of the Saccharomyces cerevisiae YFR021w/YGR223c/YPL100w ORF family suggests relations to mitochondrial/peroxisomal functions and amino acid signalling pathways. Yeast. 2001;18:1155-71 pubmed
    ..We found no unique phenotype attributed to the deletion of YGR223c. However, its function interferes with the function of the other two ORFs, as revealed by the effects of double- and triple-ORF deletions. ..
  4. Kuranda K, Grabinska K, Berges T, Karst F, Leberre V, Sokol S, et al. The YTA7 gene is involved in the regulation of the isoprenoid pathway in the yeast Saccharomyces cerevisiae. FEMS Yeast Res. 2009;9:381-90 pubmed publisher
    ..Altogether, these results provide substantial evidence of Yta7p involvement in the regulation of isoprenoid biosynthesis. ..