Gene Symbol: HEM25
Species: Saccharomyces cerevisiae S288c
Belenkiy R, Haefele A, Eisen M, Wohlrab H. The yeast mitochondrial transport proteins: new sequences and consensus residues, lack of direct relation between consensus residues and transmembrane helices, expression patterns of the transport protein genes, and protein-protein interactions with . Biochim Biophys Acta. 2000;1467:207-18 pubmed
..Interestingly, yeast two-hybrid screens, that will also be useful in identifying the function of MTPs, indicate that MIR1, AAC3, YOR100C, and YPR011C do interact with non-MTPs. ..
FernÃ¡ndez Murray J, Prykhozhij S, Dufay J, Steele S, Gaston D, Nasrallah G, et al
. Glycine and Folate Ameliorate Models of Congenital Sideroblastic Anemia. PLoS Genet. 2016;12:e1005783 pubmed publisher
..The function of SLC25A38 is not known. Here we report that the SLC25A38 protein, and its yeast homolog Hem25, are mitochondrial glycine transporters required for the initiation of heme synthesis...
Lunetti P, Damiano F, De Benedetto G, Siculella L, Pennetta A, Muto L, et al
. Characterization of Human and Yeast Mitochondrial Glycine Carriers with Implications for Heme Biosynthesis and Anemia. J Biol Chem. 2016;291:19746-59 pubmed publisher
..Herein we describe the biochemical and molecular characterization of yeast Hem25p and human SLC25A38, providing evidence that they are mitochondrial carriers for glycine...