Genomes and Genes
Gene Symbol: HEM15
Description: ferrochelatase HEM15
Alias: ferrochelatase HEM15
Species: Saccharomyces cerevisiae S288c
- Grzybowska E, Gora M, Plochocka D, Rytka J. Saccharomyces cerevisiae ferrochelatase forms a homodimer. Arch Biochem Biophys. 2002;398:170-8 pubmed..We propose a structural model of yeast ferrochelatase, based on the known structure of the human enzyme, which helps us to understand the differences in dimerization between the wild-type and mutant proteins. ..
- Urban Grimal D, Labbe Bois R. Genetic and biochemical characterization of mutants of Saccharomyces cerevisiae blocked in six different steps of heme biosynthesis. Mol Gen Genet. 1981;183:85-92 pubmed..These results are discussed in terms of possible modes of regulation of heme synthesis pathway in yeast. ..
- Lesuisse E, Santos R, Matzanke B, Knight S, Camadro J, Dancis A. Iron use for haeme synthesis is under control of the yeast frataxin homologue (Yfh1). Hum Mol Genet. 2003;12:879-89 pubmed..Deltayfh1 strains, the level of ferrochelatase (Hem15p) was very low, as a result of transcriptional repression of HEM15. However, the low amount of Hem15p was not the cause of haeme deficiency in Deltayfh1 cells...
- Kilmartin J. Sfi1p has conserved centrin-binding sites and an essential function in budding yeast spindle pole body duplication. J Cell Biol. 2003;162:1211-21 pubmed..The centrosomal human protein containing Sfi1 repeats also binds centrin in the repeat region, showing that this centrin-binding motif is conserved. ..