HEM14

Summary

Gene Symbol: HEM14
Description: oxygen-dependent protoporphyrinogen oxidase
Alias: oxygen-dependent protoporphyrinogen oxidase
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Camadro J, Thome F, Brouillet N, Labbe P. Purification and properties of protoporphyrinogen oxidase from the yeast Saccharomyces cerevisiae. Mitochondrial location and evidence for a precursor form of the protein. J Biol Chem. 1994;269:32085-91 pubmed
    ..M., Matringe, M., Scalla, R., and Labbe, P. (1991) Biochem. J. 277, 17-21) was shown to be related to partial proteolysis of the enzyme. ..
  2. Urban Grimal D, Labbe Bois R. Genetic and biochemical characterization of mutants of Saccharomyces cerevisiae blocked in six different steps of heme biosynthesis. Mol Gen Genet. 1981;183:85-92 pubmed
    ..These results are discussed in terms of possible modes of regulation of heme synthesis pathway in yeast. ..
  3. Camadro J, Urban Grimal D, Labbe P. A new assay for protoporphyrinogen oxidase - evidence for a total deficiency in that activity in a heme-less mutant of Saccharomyces cerevisiae. Biochem Biophys Res Commun. 1982;106:724-30 pubmed
  4. Huang Z, Chen K, Xu T, Zhang J, Li Y, Li W, et al. Sampangine inhibits heme biosynthesis in both yeast and human. Eukaryot Cell. 2011;10:1536-44 pubmed publisher
    ..This study also reveals a surprising essential role for the interaction between the mitochondrial ATP synthase and the electron transport chain. ..