Gene Symbol: HCA4
Description: RNA-dependent ATPase HCA4
Alias: DBP4, ECM24, RNA-dependent ATPase HCA4
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Kawasaki Y, Hiraga S, Sugino A. Interactions between Mcm10p and other replication factors are required for proper initiation and elongation of chromosomal DNA replication in Saccharomyces cerevisiae. Genes Cells. 2000;5:975-89 pubmed
  2. Garcia I, Uhlenbeck O. Differential RNA-dependent ATPase activities of four rRNA processing yeast DEAD-box proteins. Biochemistry. 2008;47:12562-73 pubmed publisher
    ..This systematic comparison of four members of the DExD/H-box family demonstrates a range of biochemical properties and lays the foundation for relating the activities of proteins to their biological functions. ..
  3. Garcia I, Albring M, Uhlenbeck O. Duplex destabilization by four ribosomal DEAD-box proteins. Biochemistry. 2012;51:10109-18 pubmed publisher
    ..Further enhancement of the strand displacement rate in the presence of ATP was observed for only Dbp3p and Rrp3p. ..
  4. Kos M, Tollervey D. The Putative RNA Helicase Dbp4p Is Required for Release of the U14 snoRNA from Preribosomes in Saccharomyces cerevisiae. Mol Cell. 2005;20:53-64 pubmed
    ..Point mutations in helicase motifs I and III of Dbp4p blocked release of U14 from preribosomes. We conclude that the helicase activity of Dbp4p is required to unwind U14 and snR41 from the pre-rRNA. ..
  5. Soltanieh S, Lapensée M, Dragon F. Nucleolar proteins Bfr2 and Enp2 interact with DEAD-box RNA helicase Dbp4 in two different complexes. Nucleic Acids Res. 2014;42:3194-206 pubmed publisher
    ..b>Dbp4, a conserved DEAD-box RNA helicase implicated in ribosome biogenesis, interacts with nucleolar proteins Bfr2 and ..
  6. Soltanieh S, Osheim Y, Spasov K, Trahan C, Beyer A, Dragon F. DEAD-box RNA helicase Dbp4 is required for small-subunit processome formation and function. Mol Cell Biol. 2015;35:816-30 pubmed publisher
    DEAD-box RNA helicase Dbp4 is required for 18S rRNA synthesis: cellular depletion of Dbp4 impairs the early cleavage reactions of the pre-rRNA and causes U14 small nucleolar RNA (snoRNA) to remain associated with pre-rRNA...
  7. Hoang T, Peng W, Vanrobays E, Krogan N, Hiley S, Beyer A, et al. Esf2p, a U3-associated factor required for small-subunit processome assembly and compaction. Mol Cell Biol. 2005;25:5523-34 pubmed
    ..The identification of ABT1 in a large-scale analysis of the human nucleolar proteome indicates that its role may also be conserved in mammals. ..
  8. Gerus M, Bonnart C, Caizergues Ferrer M, Henry Y, Henras A. Evolutionarily conserved function of RRP36 in early cleavages of the pre-rRNA and production of the 40S ribosomal subunit. Mol Cell Biol. 2010;30:1130-44 pubmed publisher
    ..In parallel, we studied the human orthologue of Rrp36p in HeLa cells, and we show that the function of this protein in early cleavages of the pre-rRNA has been conserved through evolution in eukaryotes. ..