Gene Symbol: GUP1
Description: O-acyltransferase
Alias: O-acyltransferase
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Oelkers P, Tinkelenberg A, Erdeniz N, Cromley D, Billheimer J, Sturley S. A lecithin cholesterol acyltransferase-like gene mediates diacylglycerol esterification in yeast. J Biol Chem. 2000;275:15609-12 pubmed
    ..These mechanisms may also exist in mammalian cells. ..
  2. Holst B, Lunde C, Lages F, Oliveira R, Lucas C, Kielland Brandt M. GUP1 and its close homologue GUP2, encoding multimembrane-spanning proteins involved in active glycerol uptake in Saccharomyces cerevisiae. Mol Microbiol. 2000;37:108-24 pubmed
    ..cerevisiae. The gene is named GUP1 (glycerol uptake) and, for growth on glycerol, is important as a carbon and energy source...
  3. Bosson R, Jaquenoud M, Conzelmann A. GUP1 of Saccharomyces cerevisiae encodes an O-acyltransferase involved in remodeling of the GPI anchor. Mol Biol Cell. 2006;17:2636-45 pubmed
    ..Here we show that GUP1 is essential for the synthesis of the C26:0-containing diacylglycerol anchors...
  4. Ferreira C, Lucas C. The yeast O-acyltransferase Gup1p interferes in lipid metabolism with direct consequences on the sphingolipid-sterol-ordered domains integrity/assembly. Biochim Biophys Acta. 2008;1778:2648-53 pubmed publisher
    Saccharomyces cerevisiae Gup1p is a membrane-bound O-acyltransferase. Previous works involved GUP1 in a wide range of crucial processes for cell preservation and functioning...
  5. Neves L, Lages F, Lucas C. New insights on glycerol transport in Saccharomyces cerevisiae. FEBS Lett. 2004;565:160-2 pubmed
    ..activity of a H(+)/glycerol symport, derepressed by growth on non-fermentable carbon sources, later associated with GUP1 and GUP2 genes...
  6. Bleve G, Zacheo G, Cappello M, Dellaglio F, Grieco F. Subcellular localization and functional expression of the glycerol uptake protein 1 (GUP1) of Saccharomyces cerevisiae tagged with green fluorescent protein. Biochem J. 2005;390:145-55 pubmed
    ..The subcellular localization and functional expression of biologically active Gup1-GFP chimaeras was monitored by confocal laser scanning and electron microscopy, thus supplying the first study of ..
  7. Jaquenoud M, Pagac M, Signorell A, Benghezal M, Jelk J, Bütikofer P, et al. The Gup1 homologue of Trypanosoma brucei is a GPI glycosylphosphatidylinositol remodelase. Mol Microbiol. 2008;67:202-12 pubmed
    ..Heterologous expression of the GUP1 homologue of T...
  8. Hess D, Winston F. Evidence that Spt10 and Spt21 of Saccharomyces cerevisiae play distinct roles in vivo and functionally interact with MCB-binding factor, SCB-binding factor and Snf1. Genetics. 2005;170:87-94 pubmed
    ..Taken together, these genetic interactions suggest distinct roles for Spt21 and Spt10 in vivo that are sensitive to multiple perturbations in transcription networks. ..
  9. Bleve G, Di Sansebastiano G, Grieco F. Over-expression of functional Saccharomyces cerevisiae GUP1, induces proliferation of intracellular membranes containing ER and Golgi resident proteins. Biochim Biophys Acta. 2011;1808:733-44 pubmed publisher
    High-level expression of the GUP1 gene in Saccharomyces cerevisiae resulted in the formation of proliferated structures, which hosted endoplasmic reticulum (ER), Golgi and itinerant proteins...

More Information


  1. Copic A, Latham C, Horlbeck M, D Arcangelo J, Miller E. ER cargo properties specify a requirement for COPII coat rigidity mediated by Sec13p. Science. 2012;335:1359-62 pubmed publisher
    ..Thus, Sec13p may rigidify the COPII cage and increase its membrane-bending capacity; this function could be bypassed when a bst mutation renders the membrane more deformable. ..
  2. Faria Oliveira F, Carvalho J, Belmiro C, Ramalho G, Pavão M, Lucas C, et al. Elemental biochemical analysis of the polysaccharides in the extracellular matrix of the yeast Saccharomyces cerevisiae. J Basic Microbiol. 2015;55:685-94 pubmed publisher
    ..the double deletion of the yeast homologues of the mammalian Hedgehog modulators Hhatl and Hhat, respectively yeast Gup1 and Gup2. These results pioneer the study of the molecular biology of the ECM supporting S...
  3. Losev E, Papanikou E, Rossanese O, Glick B. Cdc1p is an endoplasmic reticulum-localized putative lipid phosphatase that affects Golgi inheritance and actin polarization by activating Ca2+ signaling. Mol Cell Biol. 2008;28:3336-43 pubmed publisher
    ..The combined data fit a model in which the cdc1 mutant phenotypes result from accumulation of a phosphorylated lipid that activates Ca(2+) signaling. ..
  4. Jung J, Yun H, Lee J, Oh M. Production of 1,2-propanediol from glycerol in Saccharomyces cerevisiae. J Microbiol Biotechnol. 2011;21:846-53 pubmed
    ..GUT1), glycerol 3-phosphate dehydrogenase (GUT2), glycerol dehydrogenase (gdh), and a glycerol transporter gene (GUP1), showed increased glycerol utilization and growth rate...
  5. Tulha J, Faria Oliveira F, Lucas C, Ferreira C. Programmed cell death in Saccharomyces cerevisiae is hampered by the deletion of GUP1 gene. BMC Microbiol. 2012;12:80 pubmed publisher
    ..Therefore, we hypothesize that apoptotic process would be affected by GUP1 deletion...
  6. Yoko o T, Ichikawa D, Miyagishi Y, Kato A, Umemura M, Takase K, et al. Determination and physiological roles of the glycosylphosphatidylinositol lipid remodelling pathway in yeast. Mol Microbiol. 2013;88:140-55 pubmed publisher
    ..In addition, mass spectrometric analysis of lipid species of Flag-tagged Gas1p revealed that Gas1p contains ceramide moieties in its GPI anchor. ..