Gene Symbol: GUF1
Description: GTPase GUF1
Alias: GTPase GUF1
Species: Saccharomyces cerevisiae S288c
Kiser G, Weinert T. GUF1, a gene encoding a novel evolutionarily conserved GTPase in budding yeast. Yeast. 1995;11:1311-6 pubmed
While sequencing a region of chromosome IV adjacent to the checkpoint gene MEC3, we identified a gene we call GUF1 (GTPase of Unknown Function), which predicts a 586 amino acid GTPase of the elongation factor-type class...
Butcher R, Bhullar B, Perlstein E, Marsischky G, Labaer J, Schreiber S. Microarray-based method for monitoring yeast overexpression strains reveals small-molecule targets in TOR pathway. Nat Chem Biol. 2006;2:103-9 pubmed
Bauerschmitt H, Funes S, Herrmann J. The membrane-bound GTPase Guf1 promotes mitochondrial protein synthesis under suboptimal conditions. J Biol Chem. 2008;283:17139-46 pubmed publisher
..Here we show that the yeast counterpart of LepA, Guf1, is located in the mitochondrial matrix and tightly associated with the inner membrane...
Prestele M, Vogel F, Reichert A, Herrmann J, Ott M. Mrpl36 is important for generation of assembly competent proteins during mitochondrial translation. Mol Biol Cell. 2009;20:2615-25 pubmed publisher
..This important function seems to be carried out by a stabilizing activity of Mrpl36 on the interaction between large and small ribosomal subunits, which could influence accuracy of protein synthesis. ..