GUA1

Summary

Gene Symbol: GUA1
Description: GMP synthase (glutamine-hydrolyzing)
Alias: GMP synthase (glutamine-hydrolyzing)
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Dujardin G, Kermorgant M, Slonimski P, Boucherie H. Cloning and sequencing of the GMP synthetase-encoding gene of Saccharomyces cerevisiae. Gene. 1994;139:127-32 pubmed
    We have localised, within a Saccharomyces cerevisiae genomic fragment, the GUA1 gene whose amplification leads to the accumulation of several polypeptides on the two-dimensional (2-D) map of yeast proteins...
  2. Iglesias Gato D, Martin Marcos P, Santos M, Hinnebusch A, Tamame M. Guanine nucleotide pool imbalance impairs multiple steps of protein synthesis and disrupts GCN4 translational control in Saccharomyces cerevisiae. Genetics. 2011;187:105-22 pubmed publisher
    ..We have identified a substitution mutation (G388D) that reduces the activity of the GMP synthase Gua1 in budding yeast and the total G-nucleotide pool, leading to precipitous reductions in the GDP/GTP ratio and ATP ..