Gene Symbol: GPM1
Description: phosphoglycerate mutase GPM1
Alias: phosphoglycerate mutase GPM1
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Bataille N, Peypouquet M, Boucherie H. Identification of polypeptides of the carbon metabolism machinery on the two-dimensional protein map of Saccharomyces cerevisiae. Location of 23 additional polypeptides. Yeast. 1987;3:11-21 pubmed
    ..The criteria used to establish the identification of these polypeptides spots include migration with purified proteins, immunodetection, overproduction by plasmid-carrying strains and physiological behaviour. ..
  2. Kuhn A, Brow D. Suppressors of a cold-sensitive mutation in yeast U4 RNA define five domains in the splicing factor Prp8 that influence spliceosome activation. Genetics. 2000;155:1667-82 pubmed
  3. Zhou W, Ryan J, Zhou H. Global analyses of sumoylated proteins in Saccharomyces cerevisiae. Induction of protein sumoylation by cellular stresses. J Biol Chem. 2004;279:32262-8 pubmed
    ..Taken together, these results show that protein sumoylation is broadly involved in many cellular functions and this mass spectrometry-based proteomic approach is useful in studying the regulation of protein sumoylation in the cells. ..
  4. Roberts T, Kobor M, Bastin Shanower S, Ii M, Horte S, Gin J, et al. Slx4 regulates DNA damage checkpoint-dependent phosphorylation of the BRCT domain protein Rtt107/Esc4. Mol Biol Cell. 2006;17:539-48 pubmed
  5. White M, Fothergill Gilmore L. Development of a mutagenesis, expression and purification system for yeast phosphoglycerate mutase. Investigation of the role of active-site His181. Eur J Biochem. 1992;207:709-14 pubmed
    ..These observations are consistent with an integral role for His181 in the reaction mechanism of phosphoglycerate mutase, probably as a general acid or base. ..
  6. Rodicio R, Heinisch J. Isolation of the yeast phosphoglyceromutase gene and construction of deletion mutants. Mol Gen Genet. 1987;206:133-40 pubmed
    ..However, growth was inhibited by glucose and neither glycerol nor ethanol alone were sufficient to support growth. ..
  7. Rigden D, Alexeev D, Phillips S, Fothergill Gilmore L. The 2.3 A X-ray crystal structure of S. cerevisiae phosphoglycerate mutase. J Mol Biol. 1998;276:449-59 pubmed
    ..Electron density was apparent for a portion of the functionally important C-terminal tail, which was absent from the earlier structure, showing it to adopt a mainly helical conformation. ..
  8. Brandina I, Graham J, Lemaitre Guillier C, Entelis N, Krasheninnikov I, Sweetlove L, et al. Enolase takes part in a macromolecular complex associated to mitochondria in yeast. Biochim Biophys Acta. 2006;1757:1217-28 pubmed
    ..This suggests an unsuspected novel function for this complex in tRNA mitochondrial import. ..
  9. Mirzaei H, Rogers R, Grimes B, Eng J, Aderem A, Aebersold R. Characterizing the connectivity of poly-ubiquitin chains by selected reaction monitoring mass spectrometry. Mol Biosyst. 2010;6:2004-14 pubmed publisher
    ..cerevisiae. We then applied the method to detect toxin induced changes in the poly-ubiquitination profile in complex and enriched protein samples. ..

More Information


  1. Papini M, Nookaew I, Scalcinati G, Siewers V, Nielsen J. Phosphoglycerate mutase knock-out mutant Saccharomyces cerevisiae: physiological investigation and transcriptome analysis. Biotechnol J. 2010;5:1016-27 pubmed publisher
    ..Here, we studied the response to the deletion of the glycolytic and gluconeogenic gene GPM1, encoding for phosphoglycerate mutase. It was previously shown that a S...
  2. Peter Smits H, Hauf J, Muller S, Hobley T, Zimmermann F, Hahn Hagerdal B, et al. Simultaneous overexpression of enzymes of the lower part of glycolysis can enhance the fermentative capacity of Saccharomyces cerevisiae. Yeast. 2000;16:1325-34 pubmed
  3. Poltermann S, Kunert A, von der Heide M, Eck R, Hartmann A, Zipfel P. Gpm1p is a factor H-, FHL-1-, and plasminogen-binding surface protein of Candida albicans. J Biol Chem. 2007;282:37537-44 pubmed
    ..CaGpm1p is a surface protein as demonstrated by immunostaining and flow cytometry. A C. albicans gpm1(-/-) mutant strain was generated that did not grow on glucose-supplemented but on ethanol- and glycerol-..
  4. Vögtle F, Burkhart J, Rao S, Gerbeth C, Hinrichs J, Martinou J, et al. Intermembrane space proteome of yeast mitochondria. Mol Cell Proteomics. 2012;11:1840-52 pubmed publisher
    ..We present here the first and comprehensive proteome of IMS proteins of yeast mitochondria with 51 proteins in total. The IMS proteome will serve as a valuable source for further studies on the role of the IMS in cell life and death. ..
  5. Mostovoy Y, Thiemicke A, Hsu T, Brem R. The Role of Transcription Factors at Antisense-Expressing Gene Pairs in Yeast. Genome Biol Evol. 2016;8:1748-61 pubmed publisher
    ..we focused on the stress-induced NAD(P)H dehydratase YKL151C and its downstream neighbor, the metabolic enzyme GPM1 Previous work has implicated the region between these genes in regulation of GPM1 expression; our mutation ..