Gene Symbol: GLC7
Description: type 1 serine/threonine-protein phosphatase catalytic subunit GLC7
Alias: CID1, DIS2, type 1 serine/threonine-protein phosphatase catalytic subunit GLC7
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Hiraga S, Alvino G, Chang F, Lian H, Sridhar A, Kubota T, et al. Rif1 controls DNA replication by directing Protein Phosphatase 1 to reverse Cdc7-mediated phosphorylation of the MCM complex. Genes Dev. 2014;28:372-83 pubmed publisher
    ..Since PP1 interaction sites are evolutionarily conserved within the Rif1 sequence, it is likely that replication control by Rif1 through PP1 is a conserved mechanism. ..
  2. Frederick D, Tatchell K. The REG2 gene of Saccharomyces cerevisiae encodes a type 1 protein phosphatase-binding protein that functions with Reg1p and the Snf1 protein kinase to regulate growth. Mol Cell Biol. 1996;16:2922-31 pubmed
    The GLC7 gene of Saccharomyces cerevisiae encodes the catalytic subunit of type 1 protein phosphatase (PP1) and is essential for cell growth...
  3. Tabba S, Mangat S, McCartney R, Schmidt M. PP1 phosphatase-binding motif in Reg1 protein of Saccharomyces cerevisiae is required for interaction with both the PP1 phosphatase Glc7 and the Snf1 protein kinase. Cell Signal. 2010;22:1013-21 pubmed publisher
    ..of this key site is determined by changes in the rate of dephosphorylation catalyzed by the yeast PP1 phosphatase Glc7 in a complex with the Reg1 protein...
  4. Tu J, Carlson M. REG1 binds to protein phosphatase type 1 and regulates glucose repression in Saccharomyces cerevisiae. EMBO J. 1995;14:5939-46 pubmed
    Protein phosphatase type 1 (PP1) is encoded by GLC7, an essential gene in Saccharomyces cerevisiae. The GLC7 phosphatase is required for glucose repression and appears to function antagonistically to the SNF1 protein kinase...
  5. Hisamoto N, Sugimoto K, Matsumoto K. The Glc7 type 1 protein phosphatase of Saccharomyces cerevisiae is required for cell cycle progression in G2/M. Mol Cell Biol. 1994;14:3158-65 pubmed
    We isolated a mutant carrying a conditional mutation in the GLC7 gene, encoding the catalytic subunit of a type 1 protein phosphatase, by selection of suppressors that restored the growth defect of cdc24 mutants at high temperature and ..
  6. Tu J, Song W, Carlson M. Protein phosphatase type 1 interacts with proteins required for meiosis and other cellular processes in Saccharomyces cerevisiae. Mol Cell Biol. 1996;16:4199-206 pubmed
    ..To identify regulatory subunits and substrates of the Saccharomyces cerevisiae PP1, encoded by GLC7, we used the two-hybrid system to detect interacting proteins...
  7. Sanz P, Ludin K, Carlson M. Sip5 interacts with both the Reg1/Glc7 protein phosphatase and the Snf1 protein kinase of Saccharomyces cerevisiae. Genetics. 2000;154:99-107 pubmed
    ..We found that Sip5 also interacts strongly with Reg1, the regulatory subunit of the Reg1/Glc7 protein phosphatase 1 complex, in both two-hybrid and coimmunoprecipitation assays...
  8. Bloecher A, Tatchell K. Defects in Saccharomyces cerevisiae protein phosphatase type I activate the spindle/kinetochore checkpoint. Genes Dev. 1999;13:517-22 pubmed
    A conditional allele of type 1 protein phosphatase (glc7-129) in Saccharomyces cerevisiae causes first cycle arrest in G2/M, characterized by cells with a short spindle and high H1 kinase activity...
  9. Cannon J. Function of protein phosphatase-1, Glc7, in Saccharomyces cerevisiae. Adv Appl Microbiol. 2010;73:27-59 pubmed publisher
    ..Budding yeast, Saccharomyces cerevisiae, and its close relatives are unique among eukaryotes in having a single gene, GLC7, encoding protein phosphatase-1 (PP1)...

More Information


  1. Bloecher A, Tatchell K. Dynamic localization of protein phosphatase type 1 in the mitotic cell cycle of Saccharomyces cerevisiae. J Cell Biol. 2000;149:125-40 pubmed
    Protein phosphatase type I (PP1), encoded by the single essential gene GLC7 in Saccharomyces cerevisiae, functions in diverse cellular processes...
  2. He X, Moore C. Regulation of yeast mRNA 3' end processing by phosphorylation. Mol Cell. 2005;19:619-29 pubmed
    Recent studies have found that the phosphatase Glc7 associates with the yeast cleavage/polyadenylation factor (CPF), but the role of Glc7 in 3' end processing has not been investigated...
  3. Dombek K, Voronkova V, Raney A, Young E. Functional analysis of the yeast Glc7-binding protein Reg1 identifies a protein phosphatase type 1-binding motif as essential for repression of ADH2 expression. Mol Cell Biol. 1999;19:6029-40 pubmed
    ..Surprisingly, however, mutant forms of the yeast PP1 homologue Glc7, which are unable to repress expression of another glucose-regulated gene, SUC2, fully repressed ADH2...
  4. Zhang S, Guha S, Volkert F. The Saccharomyces SHP1 gene, which encodes a regulator of phosphoprotein phosphatase 1 with differential effects on glycogen metabolism, meiotic differentiation, and mitotic cell cycle progression. Mol Cell Biol. 1995;15:2037-50 pubmed
    The phosphoprotein phosphatase 1 (PP1) catalytic subunit encoded by the Saccharomyces GLC7 gene is involved in control of glycogen metabolism, meiosis, translation, chromosome segregation, cell polarity, and G2/M cell cycle progression...
  5. Ramaswamy N, Li L, Khalil M, Cannon J. Regulation of yeast glycogen metabolism and sporulation by Glc7p protein phosphatase. Genetics. 1998;149:57-72 pubmed
    ..Analysis of 24 glc7 mutants, isolated primarily by their glycogen accumulation traits, revealed that every mutated Glc7p residue ..
  6. MacKelvie S, Andrews P, Stark M. The Saccharomyces cerevisiae gene SDS22 encodes a potential regulator of the mitotic function of yeast type 1 protein phosphatase. Mol Cell Biol. 1995;15:3777-85 pubmed
    ..We have also generated a temperature-sensitive allele of GLC7 (glc7-12) which causes a block to the completion of mitosis at the restrictive temperature...
  7. Alms G, Sanz P, Carlson M, Haystead T. Reg1p targets protein phosphatase 1 to dephosphorylate hexokinase II in Saccharomyces cerevisiae: characterizing the effects of a phosphatase subunit on the yeast proteome. EMBO J. 1999;18:4157-68 pubmed
    ..These results demonstrate that Reg1p targets PP-1C to dephosphorylate Hxk2p in vivo and that the motif (K/R)(X) (I/V)XF is necessary for its PP-1 targeting function. ..
  8. Wu X, Hart H, Cheng C, Roach P, Tatchell K. Characterization of Gac1p, a regulatory subunit of protein phosphatase type I involved in glycogen accumulation in Saccharomyces cerevisiae. Mol Genet Genomics. 2001;265:622-35 pubmed
    GAC1 and GLC7 encode regulatory and catalytic subunits, respectively, of a type 1 phosphatase (PP1) in Saccharomyces cerevisiae that controls glycogen synthesis by regulating the phosphorylation state of glycogen synthase (Gsy2p)...
  9. Zhang K, Lin W, Latham J, Riefler G, Schumacher J, Chan C, et al. The Set1 methyltransferase opposes Ipl1 aurora kinase functions in chromosome segregation. Cell. 2005;122:723-34 pubmed
    A balance in the activities of the Ipl Aurora kinase and the Glc7 phosphatase is essential for normal chromosome segregation in yeast. We report here that this balance is modulated by the Set1 methyltransferase...
  10. Hsu J, Sun Z, Li X, Reuben M, Tatchell K, Bishop D, et al. Mitotic phosphorylation of histone H3 is governed by Ipl1/aurora kinase and Glc7/PP1 phosphatase in budding yeast and nematodes. Cell. 2000;102:279-91 pubmed
    ..Here we report that Ipl1/aurora kinase and its genetically interacting phosphatase, Glc7/PP1, are responsible for the balance of H3 phosphorylation during mitosis in Saccharomyces cerevisiae and ..
  11. Andrews P, Stark M. Type 1 protein phosphatase is required for maintenance of cell wall integrity, morphogenesis and cell cycle progression in Saccharomyces cerevisiae. J Cell Sci. 2000;113 ( Pt 3):507-20 pubmed
    b>GLC7 encodes the catalytic subunit of type 1 protein serine/threonine phosphatase (PP1) in the yeast Saccharomyces cerevisiae...
  12. Kang J, Cheeseman I, Kallstrom G, Velmurugan S, Barnes G, Chan C. Functional cooperation of Dam1, Ipl1, and the inner centromere protein (INCENP)-related protein Sli15 during chromosome segregation. J Cell Biol. 2001;155:763-74 pubmed
    ..Given their dual association with microtubules and kinetochores, Ipl1, Sli15, and Dam1 may play crucial roles in regulating chromosome-spindle interactions or in the movement of kinetochores along microtubules. ..
  13. Feng Z, Wilson S, Peng Z, Schlender K, Reimann E, Trumbly R. The yeast GLC7 gene required for glycogen accumulation encodes a type 1 protein phosphatase. J Biol Chem. 1991;266:23796-801 pubmed
    The glc7 mutant of the yeast Saccharomyces cerevisiae does not accumulate glycogen due to a defect in glycogen synthase activation (Peng, Z., Trumbly, R. J., and Reimann, E.M. (1990) J. Biol. Chem...
  14. Tatchell K, Makrantoni V, Stark M, Robinson L. Temperature-sensitive ipl1-2/Aurora B mutation is suppressed by mutations in TOR complex 1 via the Glc7/PP1 phosphatase. Proc Natl Acad Sci U S A. 2011;108:3994-9 pubmed publisher
    ..The protein phosphatase Glc7/PP1 opposes Ipl1 for some of these activities...
  15. Hochwagen A, Tham W, Brar G, Amon A. The FK506 binding protein Fpr3 counteracts protein phosphatase 1 to maintain meiotic recombination checkpoint activity. Cell. 2005;122:861-73 pubmed
    ..Our findings define a branch of the recombination checkpoint involved in the adaptation to persistent chromosomal damage and a critical function for FK506 binding proteins during meiosis. ..
  16. Cui D, Brown C, Chiang H. The type 1 phosphatase Reg1p-Glc7p is required for the glucose-induced degradation of fructose-1,6-bisphosphatase in the vacuole. J Biol Chem. 2004;279:9713-24 pubmed
    ..The glc7-T152K mutant strain exhibited a reduced Reg1p binding along with defects in FBPase degradation and Vid vesicle ..
  17. Bharucha J, Larson J, Gao L, Daves L, Tatchell K. Ypi1, a positive regulator of nuclear protein phosphatase type 1 activity in Saccharomyces cerevisiae. Mol Biol Cell. 2008;19:1032-45 pubmed publisher
    ..We show here that the budding yeast Ypi1 protein is a nuclear protein that functions with PP1 (Glc7) in this mitotic role...
  18. Lin J, Lis J. Glycogen synthase phosphatase interacts with heat shock factor to activate CUP1 gene transcription in Saccharomyces cerevisiae. Mol Cell Biol. 1999;19:3237-45 pubmed
    ..The GAC1 gene encodes the regulatory subunit for a type 1 serine/threonine phosphoprotein phosphatase, Glc7. Both gac1 and glc7 mutations had little effect on HSF activation of gene transcription of two heat shock genes, ..
  19. Sassoon I, Severin F, Andrews P, Taba M, Kaplan K, Ashford A, et al. Regulation of Saccharomyces cerevisiae kinetochores by the type 1 phosphatase Glc7p. Genes Dev. 1999;13:545-55 pubmed
    ..By use of phosphatase inhibitors and a type 1 protein phosphatase mutant (glc7-10), we show that the microtubule binding activity, but not the centromeric DNA-binding activity, of the ..
  20. Pedelini L, Marquina M, Arino J, Casamayor A, Sanz L, Bollen M, et al. YPI1 and SDS22 proteins regulate the nuclear localization and function of yeast type 1 phosphatase Glc7. J Biol Chem. 2007;282:3282-92 pubmed
    We have recently characterized Ypi1 as an inhibitory subunit of yeast Glc7 PP1 protein phosphatase...
  21. Stuart J, Frederick D, Varner C, Tatchell K. The mutant type 1 protein phosphatase encoded by glc7-1 from Saccharomyces cerevisiae fails to interact productively with the GAC1-encoded regulatory subunit. Mol Cell Biol. 1994;14:896-905 pubmed
    ..The glycogen accumulation phenotype of gac1 is similar to that of glc7-1, a type 1 protein phosphatase mutant...
  22. Gilbert W, Guthrie C. The Glc7p nuclear phosphatase promotes mRNA export by facilitating association of Mex67p with mRNA. Mol Cell. 2004;13:201-12 pubmed
    ..We propose a model whereby a cycle of cytoplasmic phosphorylation and nuclear dephosphorylation of shuttling SR adaptor proteins regulates Mex67p:Mtr2p/NXF1:p15-dependent mRNA export. ..
  23. Peters C, Andrews P, Stark M, Cesaro Tadic S, Glatz A, Podtelejnikov A, et al. Control of the terminal step of intracellular membrane fusion by protein phosphatase 1. Science. 1999;285:1084-7 pubmed
    ..The PP1-calmodulin complex was required at multiple sites of intracellular trafficking; hence, PP1 may be a general factor controlling membrane bilayer mixing. ..
  24. Peggie M, MacKelvie S, Bloecher A, Knatko E, Tatchell K, Stark M. Essential functions of Sds22p in chromosome stability and nuclear localization of PP1. J Cell Sci. 2002;115:195-206 pubmed
    ..Like some glc7 mutations, sds22-6 can suppress the Ts(-) growth defect associated with ipl1-2, a loss of function mutation in a ..
  25. Pinsky B, Kotwaliwale C, Tatsutani S, Breed C, Biggins S. Glc7/protein phosphatase 1 regulatory subunits can oppose the Ipl1/aurora protein kinase by redistributing Glc7. Mol Cell Biol. 2006;26:2648-60 pubmed
    Faithful chromosome segregation depends on the opposing activities of the budding yeast Glc7/PP1 protein phosphatase and Ipl1/Aurora protein kinase...
  26. Francisco L, Wang W, Chan C. Type 1 protein phosphatase acts in opposition to IpL1 protein kinase in regulating yeast chromosome segregation. Mol Cell Biol. 1994;14:4731-40 pubmed
    ..kinase in regulating chromosome segregation in yeast, a truncated version of the previously identified DIS2S1/GLC7 gene was isolated as a dosage-dependent suppressor of ipl1ts mutations...
  27. Cheng Y, Chen R. The AAA-ATPase Cdc48 and cofactor Shp1 promote chromosome bi-orientation by balancing Aurora B activity. J Cell Sci. 2010;123:2025-34 pubmed publisher
    ..Furthermore, Cdc48-Shp1 positively regulates Glc7/protein phosphatase 1 by facilitating nuclear localization of Glc7, whereas it opposes Ipl1/Aurora B kinase ..
  28. Larson J, Bharucha J, Ceaser S, Salamon J, Richardson C, Rivera S, et al. Protein phosphatase type 1 directs chitin synthesis at the bud neck in Saccharomyces cerevisiae. Mol Biol Cell. 2008;19:3040-51 pubmed publisher
    ..Bni4 also associates with the yeast protein phosphatase (PP1) catalytic subunit, Glc7. To identify regions of Bni4 necessary for its targeting functions, we created a collection of 23 deletion mutants ..
  29. Wu X, Tatchell K. Mutations in yeast protein phosphatase type 1 that affect targeting subunit binding. Biochemistry. 2001;40:7410-20 pubmed
    ..To test this hypothesis, 11 variants of yeast PP1 (Glc7) were constructed in which one or more of the residues comprising the groove were changed to alanine...
  30. Sanz P, Alms G, Haystead T, Carlson M. Regulatory interactions between the Reg1-Glc7 protein phosphatase and the Snf1 protein kinase. Mol Cell Biol. 2000;20:1321-8 pubmed
    Protein phosphatase 1, comprising the regulatory subunit Reg1 and the catalytic subunit Glc7, has a role in glucose repression in Saccharomyces cerevisiae...
  31. Williams Hart T, Wu X, Tatchell K. Protein phosphatase type 1 regulates ion homeostasis in Saccharomyces cerevisiae. Genetics. 2002;160:1423-37 pubmed
    Protein phosphatase type 1 (PP1) is encoded by the essential gene GLC7 in Saccharomyces cerevisiae. glc7-109 (K259A, R260A) has a dominant, hyperglycogen defect and a recessive, ion and drug sensitivity...
  32. Cullen P, Sprague G. The Glc7p-interacting protein Bud14p attenuates polarized growth, pheromone response, and filamentous growth in Saccharomyces cerevisiae. Eukaryot Cell. 2002;1:884-94 pubmed
    ..The genetic interactions between BUD14 and GLC7 suggested a role for Glc7p in filamentous growth, and Glc7p was found to have a positive function in filamentous ..
  33. Nedea E, He X, Kim M, Pootoolal J, Zhong G, Canadien V, et al. Organization and function of APT, a subcomplex of the yeast cleavage and polyadenylation factor involved in the formation of mRNA and small nucleolar RNA 3'-ends. J Biol Chem. 2003;278:33000-10 pubmed
    ..The latter can form a distinct complex, APT, in which Pti1, Swd2, a type I protein phosphatase (Glc7), Ssu72 (a TFIIB and RNA polymerase II-associated factor), Ref2, and Syc1 are associated with the Pta1 subunit of ..
  34. Kozubowski L, Panek H, Rosenthal A, Bloecher A, DeMarini D, Tatchell K. A Bni4-Glc7 phosphatase complex that recruits chitin synthase to the site of bud emergence. Mol Biol Cell. 2003;14:26-39 pubmed herein that Bni4 is also a limiting determinant for the targeting of the type 1 serine/threonine phosphatase (Glc7) to the bud neck...
  35. Bailis J, Roeder G. Pachytene exit controlled by reversal of Mek1-dependent phosphorylation. Cell. 2000;101:211-21 pubmed
    ..Mek1 kinase activity and checkpoint-induced pachytene arrest are counteracted by protein phosphatase type 1 (Glc7). Glc7 coimmunoprecipitates with Red1, colocalizes with Red1 on chromosomes, and dephosphorylates Red1 in vitro...
  36. Pinsky B, Nelson C, Biggins S. Protein phosphatase 1 regulates exit from the spindle checkpoint in budding yeast. Curr Biol. 2009;19:1182-7 pubmed publisher
    ..Here, we show that the catalytic subunit of the budding yeast protein phosphatase 1 (PP1) homolog, Glc7, regulates exit from the checkpoint...
  37. Nedea E, Nalbant D, Xia D, Theoharis N, Suter B, Richardson C, et al. The Glc7 phosphatase subunit of the cleavage and polyadenylation factor is essential for transcription termination on snoRNA genes. Mol Cell. 2008;29:577-87 pubmed publisher
    b>Glc7, the yeast protein phosphatase 1, is a component of the cleavage and polyadenylation factor (CPF)...
  38. Castermans D, Somers I, Kriel J, Louwet W, Wera S, Versele M, et al. Glucose-induced posttranslational activation of protein phosphatases PP2A and PP1 in yeast. Cell Res. 2012;22:1058-77 pubmed publisher
    ..Rts1 interacted with both Pph21 and Glc7 under different conditions and these interactions were Reg1 dependent...
  39. Hisamoto N, Frederick D, Sugimoto K, Tatchell K, Matsumoto K. The EGP1 gene may be a positive regulator of protein phosphatase type 1 in the growth control of Saccharomyces cerevisiae. Mol Cell Biol. 1995;15:3767-76 pubmed
    The Saccharomyces cerevisiae GLC7 gene encodes the catalytic subunit of type 1 protein phosphatase (PP1) and is required for cell growth...
  40. Tung H, Wang W, Chan C. Regulation of chromosome segregation by Glc8p, a structural homolog of mammalian inhibitor 2 that functions as both an activator and an inhibitor of yeast protein phosphatase 1. Mol Cell Biol. 1995;15:6064-74 pubmed
    ..growth phenotype of conditional ipl1-1ts mutants can be suppressed by a partial loss-of-function mutation in the GLC7 gene, which encodes the catalytic subunit (PP1C) of protein phosphatase 1, thus suggesting that this enzyme acts in ..
  41. Garcia Gimeno M, Munoz I, Arino J, Sanz P. Molecular characterization of Ypi1, a novel Saccharomyces cerevisiae type 1 protein phosphatase inhibitor. J Biol Chem. 2003;278:47744-52 pubmed
    ..Ypi1 interacts physically in vitro with both Glc7 and Ppz1 phosphatase catalytic subunits, as shown by pull-down assays...
  42. Huang D, Chun K, Goebl M, Roach P. Genetic interactions between REG1/HEX2 and GLC7, the gene encoding the protein phosphatase type 1 catalytic subunit in Saccharomyces cerevisiae. Genetics. 1996;143:119-27 pubmed
    Mutations in GLC7, the gene encoding the type 1 protein phosphatase catalytic subunit, cause a variety of abberrant phenotypes in yeast, such as impaired glycogen synthesis and relief of glucose repression of the expression of some genes...
  43. Good P, Kendall A, Ignatz Hoover J, Miller E, Pai D, Rivera S, et al. Silencing near tRNA genes is nucleosome-mediated and distinct from boundary element function. Gene. 2013;526:7-15 pubmed publisher
    ..The enzymes include an Rpd3 deacetylase complex, Hos1 deacetylase, Glc7 phosphatase, and the RSC nucleosome remodeling activity, but not multiple other activities required for other ..
  44. Rodriguez Hernandez C, Guinovart J, Murguia J. Anti-diabetic and anti-obesity agent sodium tungstate enhances GCN pathway activation through Glc7p inhibition. FEBS Lett. 2012;586:270-6 pubmed publisher
    ..Therefore tungstate alleviates nutrient stress in yeast by in vivo inhibition of Glc7p. These data uncover a potential role for tungstate in the treatment of PP1 and GCN related diseases. ..
  45. Hooks K, Naseeb S, Parker S, Griffiths Jones S, Delneri D. Novel Intronic RNA Structures Contribute to Maintenance of Phenotype in Saccharomyces cerevisiae. Genetics. 2016;203:1469-81 pubmed publisher
    ..We deleted the novel intronic RNA structure within the GLC7 intron and showed that this region, rather than the intron itself, is responsible for the cell's ability to respond ..
  46. He X, Khan A, Cheng H, Pappas D, Hampsey M, Moore C. Functional interactions between the transcription and mRNA 3' end processing machineries mediated by Ssu72 and Sub1. Genes Dev. 2003;17:1030-42 pubmed
  47. Venturi G, Bloecher A, Williams Hart T, Tatchell K. Genetic interactions between GLC7, PPZ1 and PPZ2 in saccharomyces cerevisiae. Genetics. 2000;155:69-83 pubmed
    b>GLC7 encodes an essential serine/threonine protein type I phosphatase in Saccharomyces cerevisiae. Three other phosphatases (Ppz1p, Ppz2p, and Sal6p) share >59% identity in their catalytic region with Glc7p...
  48. Orii M, Kono K, Wen H, Nakanishi M. PP1-Dependent Formin Bnr1 Dephosphorylation and Delocalization from a Cell Division Site. PLoS ONE. 2016;11:e0146941 pubmed publisher
    ..Impaired PP1/Glc7 activity delayed Bnr1 release and dephosphorylation, Bni1 recruitment and actomyosin ring formation at the division ..
  49. Chandrashekarappa D, McCartney R, Schmidt M. Subunit and domain requirements for adenylate-mediated protection of Snf1 kinase activation loop from dephosphorylation. J Biol Chem. 2011;286:44532-41 pubmed publisher
    ..Therefore, the exact means by which the different adenylate nucleotides are distinguished by the Snf1 enzyme may differ compared with its mammalian ortholog. ..
  50. Cairo L, Ptak C, Wozniak R. Mitosis-specific regulation of nuclear transport by the spindle assembly checkpoint protein Mad1p. Mol Cell. 2013;49:109-20 pubmed publisher
    ..We propose that a distinct branch of the SAC exists in which Mad1p senses unattached kinetochores and, by altering NPC transport activity, regulates the nuclear environment of the spindle. ..
  51. Lenssen E, James N, Pedruzzi I, Dubouloz F, Cameroni E, Bisig R, et al. The Ccr4-Not complex independently controls both Msn2-dependent transcriptional activation--via a newly identified Glc7/Bud14 type I protein phosphatase module--and TFIID promoter distribution. Mol Cell Biol. 2005;25:488-98 pubmed alteration of the posttranslational modification status of Msn2, which depends on the type 1 protein phosphatase Glc7 and its newly identified subunit Bud14...
  52. Dav A, Cooley C, Garg M, Bianchi A. Protein phosphatase 1 recruitment by Rif1 regulates DNA replication origin firing by counteracting DDK activity. Cell Rep. 2014;7:53-61 pubmed publisher
    ..These findings elucidate the mechanism of action of Rif1 in the control of DNA replication and demonstrate a role of PP1 phosphatases in the regulation of origin firing...
  53. Terry Lorenzo R, Elliot E, Weiser D, Prickett T, Brautigan D, Shenolikar S. Neurabins recruit protein phosphatase-1 and inhibitor-2 to the actin cytoskeleton. J Biol Chem. 2002;277:46535-43 pubmed
    ..I-2 complex to actin cytoskeleton and regulate cell morphology. ..
  54. Schreieck A, Easter A, Etzold S, Wiederhold K, Lidschreiber M, Cramer P, et al. RNA polymerase II termination involves C-terminal-domain tyrosine dephosphorylation by CPF subunit Glc7. Nat Struct Mol Biol. 2014;21:175-179 pubmed publisher
    ..Here we show that CPF from Saccharomyces cerevisiae is a Pol II-CTD phosphatase and that the CPF subunit Glc7 dephosphorylates Tyr1 in vitro...
  55. Anderson C, Tatchell K. Hyperactive glycogen synthase mutants of Saccharomyces cerevisiae suppress the glc7-1 protein phosphatase mutant. J Bacteriol. 2001;183:821-9 pubmed
    A yeast glc7-1 mutant expressing a variant of protein phosphatase type 1 fails to accumulate glycogen...
  56. Tachikawa H, Bloecher A, Tatchell K, Neiman A. A Gip1p-Glc7p phosphatase complex regulates septin organization and spore wall formation. J Cell Biol. 2001;155:797-808 pubmed
    ..Here we show that GIP1 and the protein phosphatase 1 encoded by GLC7 play essential roles in spore development...
  57. Dichtl B, Blank D, Ohnacker M, Friedlein A, Roeder D, Langen H, et al. A role for SSU72 in balancing RNA polymerase II transcription elongation and termination. Mol Cell. 2002;10:1139-50 pubmed
    ..The sum of our analyses suggests a negative influence of Ssu72p on RNAP II during transcription that affects the commitment to either elongation or termination. ..
  58. Ghosh A, Cannon J. Analysis of protein phosphatase-1 and aurora protein kinase suppressors reveals new aspects of regulatory protein function in Saccharomyces cerevisiae. PLoS ONE. 2013;8:e69133 pubmed publisher
    ..Overexpression of the sole PP1, Glc7, in budding yeast, Saccharomyces cerevisiae, is lethal...
  59. Cheng Y, Chen R. Assembly and quality control of the protein phosphatase 1 holoenzyme involves the Cdc48-Shp1 chaperone. J Cell Sci. 2015;128:1180-92 pubmed publisher
    ..Nuclear localization of Glc7, the catalytic subunit of PP1 in budding yeast, requires the AAA-ATPase Cdc48 and its adaptor Shp1 through an ..
  60. Maziarz M, Shevade A, Barrett L, Kuchin S. Springing into Action: Reg2 Negatively Regulates Snf1 Protein Kinase and Facilitates Recovery from Prolonged Glucose Starvation in Saccharomyces cerevisiae. Appl Environ Microbiol. 2016;82:3875-3885 pubmed publisher
    ..This involves the function of the type 1 protein phosphatase Glc7, which is targeted to Snf1 by a regulatory subunit, Reg1...
  61. Fréville A, Landrieu I, García Gimeno M, Vicogne J, Montbarbon M, Bertin B, et al. Plasmodium falciparum inhibitor-3 homolog increases protein phosphatase type 1 activity and is essential for parasitic survival. J Biol Chem. 2012;287:1306-21 pubmed publisher
    ..The main localization of a GFP-tagged PfI3 in the nucleus of all blood stage parasites is compatible with a regulatory role of PfI3 on the activity of nuclear PfPP1. ..
  62. Wek R, Cannon J, Dever T, Hinnebusch A. Truncated protein phosphatase GLC7 restores translational activation of GCN4 expression in yeast mutants defective for the eIF-2 alpha kinase GCN2. Mol Cell Biol. 1992;12:5700-10 pubmed
    ..We identified a truncated form of the GLC7 gene, encoding the catalytic subunit of a type 1 protein phosphatase, by its ability to restore derepression of ..