Gene Symbol: GIM5
Alias: PFD5, Gim5p
Species: Saccharomyces cerevisiae S288c
Geissler S, Siegers K, Schiebel E. A novel protein complex promoting formation of functional alpha- and gamma-tubulin. EMBO J. 1998;17:952-66 pubmed
We describe the identification of GIM1/YKE2, GIM2/PAC10, GIM3, GIM4 and GIM5 in a screen for mutants that are synthetically lethal with tub4-1, encoding a mutated yeast gamma-tubulin...
Vainberg I, Lewis S, Rommelaere H, Ampe C, Vandekerckhove J, Klein H, et al
. Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin. Cell. 1998;93:863-73 pubmed
..We show that by directing target proteins to chaperonin, prefoldin promotes folding in an environment in which there are many competing pathways for nonnative proteins. ..
Malagon F, Tong A, Shafer B, Strathern J. Genetic interactions of DST1 in Saccharomyces cerevisiae suggest a role of TFIIS in the initiation-elongation transition. Genetics. 2004;166:1215-27 pubmed
..We showed that: (1) dst1 and rpb9 mutants have a synthetic growth defective phenotype when combined with fyv4, gim5, htz1, yal011w, ybr231c, soh1, vps71, and vps72 mutants that is exacerbated during germination or at high salt ..
Millán Zambrano G, Rodriguez Gil A, Peñate X, de Miguel Jiménez L, Morillo Huesca M, Krogan N, et al
. The prefoldin complex regulates chromatin dynamics during transcription elongation. PLoS Genet. 2013;9:e1003776 pubmed publisher
..This study establishes the involvement of prefoldin in transcription elongation, and supports a role for this complex in cotranscriptional histone eviction. ..
Brew C, Huffaker T. The yeast ubiquitin protease, Ubp3p, promotes protein stability. Genetics. 2002;162:1079-89 pubmed
..article we show that the temperature-sensitive stu1-5 allele is synthetically lethal in combination with ubp3, gim1-gim5, and kem1 mutations. The primary focus of this article is on the stu1-5 ubp3 interaction...
Deplazes A, Möckli N, Luke B, Auerbach D, Peter M. Yeast Uri1p promotes translation initiation and may provide a link to cotranslational quality control. EMBO J. 2009;28:1429-41 pubmed publisher
..Together with genetic data, these interactions indicate that Uri1p may coordinate translation initiation and cotranslational quality control. ..