GIM4

Summary

Gene Symbol: GIM4
Description: tubulin-binding prefolding complex subunit GIM4
Alias: PFD2, tubulin-binding prefolding complex subunit GIM4
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Geissler S, Siegers K, Schiebel E. A novel protein complex promoting formation of functional alpha- and gamma-tubulin. EMBO J. 1998;17:952-66 pubmed
    We describe the identification of GIM1/YKE2, GIM2/PAC10, GIM3, GIM4 and GIM5 in a screen for mutants that are synthetically lethal with tub4-1, encoding a mutated yeast gamma-tubulin...
  2. Mayer M, Pot I, Chang M, Xu H, Aneliunas V, Kwok T, et al. Identification of protein complexes required for efficient sister chromatid cohesion. Mol Biol Cell. 2004;15:1736-45 pubmed
    ..Furthermore, we find that genes involved in mitotic spindle integrity and positioning have a previously unrecognized role in sister chromatid cohesion. ..
  3. Vainberg I, Lewis S, Rommelaere H, Ampe C, Vandekerckhove J, Klein H, et al. Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin. Cell. 1998;93:863-73 pubmed
    ..We show that by directing target proteins to chaperonin, prefoldin promotes folding in an environment in which there are many competing pathways for nonnative proteins. ..
  4. Brew C, Huffaker T. The yeast ubiquitin protease, Ubp3p, promotes protein stability. Genetics. 2002;162:1079-89 pubmed
    ..Overall, these data support the idea that Ubp3p has a general role in the reversal of protein ubiquitination. ..
  5. Lee M, Spencer F. Bipolar orientation of chromosomes in Saccharomyces cerevisiae is monitored by Mad1 and Mad2, but not by Mad3. Proc Natl Acad Sci U S A. 2004;101:10655-60 pubmed
    ..Cells without MAD3 were checkpoint-proficient. We conclude that Mad1 and Mad2 are required to detect bipolar orientation and/or tension at kinetochores, whereas Mad3 is not. ..