Gene Symbol: GIM3
Description: tubulin-binding prefolding complex subunit GIM3
Alias: PFD4, tubulin-binding prefolding complex subunit GIM3
Species: Saccharomyces cerevisiae S288c
Geissler S, Siegers K, Schiebel E. A novel protein complex promoting formation of functional alpha- and gamma-tubulin. EMBO J. 1998;17:952-66 pubmed
We describe the identification of GIM1/YKE2, GIM2/PAC10, GIM3, GIM4 and GIM5 in a screen for mutants that are synthetically lethal with tub4-1, encoding a mutated yeast gamma-tubulin...
Vainberg I, Lewis S, Rommelaere H, Ampe C, Vandekerckhove J, Klein H, et al
. Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin. Cell. 1998;93:863-73 pubmed
..We show that by directing target proteins to chaperonin, prefoldin promotes folding in an environment in which there are many competing pathways for nonnative proteins. ..
Tabuchi M, Audhya A, Parsons A, Boone C, Emr S. The phosphatidylinositol 4,5-biphosphate and TORC2 binding proteins Slm1 and Slm2 function in sphingolipid regulation. Mol Cell Biol. 2006;26:5861-75 pubmed
..Together, our data suggest that Slm1 and Slm2 define a molecular link between phosphoinositide and sphingolipid signaling and thereby regulate actin cytoskeleton organization. ..
Deplazes A, Möckli N, Luke B, Auerbach D, Peter M. Yeast Uri1p promotes translation initiation and may provide a link to cotranslational quality control. EMBO J. 2009;28:1429-41 pubmed publisher
..Together with genetic data, these interactions indicate that Uri1p may coordinate translation initiation and cotranslational quality control. ..
Millán Zambrano G, Rodriguez Gil A, Peñate X, de Miguel Jiménez L, Morillo Huesca M, Krogan N, et al
. The prefoldin complex regulates chromatin dynamics during transcription elongation. PLoS Genet. 2013;9:e1003776 pubmed publisher
..This study establishes the involvement of prefoldin in transcription elongation, and supports a role for this complex in cotranscriptional histone eviction. ..
Brew C, Huffaker T. The yeast ubiquitin protease, Ubp3p, promotes protein stability. Genetics. 2002;162:1079-89 pubmed
..Overall, these data support the idea that Ubp3p has a general role in the reversal of protein ubiquitination. ..
Mayer M, Pot I, Chang M, Xu H, Aneliunas V, Kwok T, et al
. Identification of protein complexes required for efficient sister chromatid cohesion. Mol Biol Cell. 2004;15:1736-45 pubmed
..Furthermore, we find that genes involved in mitotic spindle integrity and positioning have a previously unrecognized role in sister chromatid cohesion. ..
Scarfone I, Venturetti M, Hotz M, Lengefeld J, Barral Y, Piatti S. Asymmetry of the budding yeast Tem1 GTPase at spindle poles is required for spindle positioning but not for mitotic exit. PLoS Genet. 2015;11:e1004938 pubmed publisher
..Thus, asymmetry of the Bub2/Bfa1/Tem1 complex is crucial to control Kar9 distribution and spindle positioning during mitosis. ..
Comyn S, Young B, Loewen C, Mayor T. Prefoldin Promotes Proteasomal Degradation of Cytosolic Proteins with Missense Mutations by Maintaining Substrate Solubility. PLoS Genet. 2016;12:e1006184 pubmed publisher
..In addition to the E3 ubiquitin ligase Ubr1, we identified the prefoldin chaperone subunit Gim3 as an important quality control factor...