Gene Symbol: GID8
Description: glucose-induced degradation complex subunit GID8
Alias: DCR1, glucose-induced degradation complex subunit GID8
Species: Saccharomyces cerevisiae S288c
Regelmann J, Schüle T, Josupeit F, Horak J, Rose M, Entian K, et al
. Catabolite degradation of fructose-1,6-bisphosphatase in the yeast Saccharomyces cerevisiae: a genome-wide screen identifies eight novel GID genes and indicates the existence of two degradation pathways. Mol Biol Cell. 2003;14:1652-63 pubmed
..The influence of Ubp14p, a deubiquitinating enzyme, on proteasome-dependent catabolite degradation was further uncovered. ..
Bogomolnaya L, Pathak R, Guo J, Polymenis M. Roles of the RAM signaling network in cell cycle progression in Saccharomyces cerevisiae. Curr Genet. 2006;49:384-92 pubmed
..Taken together, our results point to a complex regulation of cell proliferation by RAM proteins, in a non-uniform manner that was not previously anticipated. ..
Pitre S, Dehne F, Chan A, Cheetham J, Duong A, Emili A, et al
. PIPE: a protein-protein interaction prediction engine based on the re-occurring short polypeptide sequences between known interacting protein pairs. BMC Bioinformatics. 2006;7:365 pubmed
..Using PIPE, we identified a novel interaction between YGL227W (vid30) and YMR135C (gid8) yeast proteins...
Santt O, Pfirrmann T, Braun B, Juretschke J, Kimmig P, Scheel H, et al
. The yeast GID complex, a novel ubiquitin ligase (E3) involved in the regulation of carbohydrate metabolism. Mol Biol Cell. 2008;19:3323-33 pubmed publisher
..Our study uncovers a new type of ubiquitin ligase complex composed of novel subunits involved in carbohydrate metabolism and identifies Gid4/Vid24 as a major regulator of this E3. ..
Menssen R, Schweiggert J, Schreiner J, Kusevic D, Reuther J, Braun B, et al
. Exploring the topology of the Gid complex, the E3 ubiquitin ligase involved in catabolite-induced degradation of gluconeogenic enzymes. J Biol Chem. 2012;287:25602-14 pubmed publisher
..Under gluconeogenic conditions the E3 ligase is composed of six subunits (Gid1/Vid30, Gid2/Rmd5, Gid5/Vid28, Gid7, Gid8, and Gid9/Fyv10)...
Pathak R, Bogomolnaya L, Guo J, Polymenis M. Gid8p (Dcr1p) and Dcr2p function in a common pathway to promote START completion in Saccharomyces cerevisiae. Eukaryot Cell. 2004;3:1627-38 pubmed
..in Saccharomyces cerevisiae overexpression of the dosage-dependent cell cycle regulator genes DCR2 (YLR361C) and GID8 (DCR1/YMR135C) accelerates initiation of DNA replication...