GBP2

Summary

Gene Symbol: GBP2
Description: single-stranded telomeric DNA-binding/mRNA-binding protein
Alias: RLF6, single-stranded telomeric DNA-binding/mRNA-binding protein
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Windgassen M, Krebber H. Identification of Gbp2 as a novel poly(A)+ RNA-binding protein involved in the cytoplasmic delivery of messenger RNAs in yeast. EMBO Rep. 2003;4:278-83 pubmed
    ..Here, we present the identification of Gbp2 as a novel shuttling RNA-binding protein in Saccharomyces cerevisiae...
  2. Pang T, Wang C, Hsu C, Chen M, Lin J. Exposure of single-stranded telomeric DNA causes G2/M cell cycle arrest in Saccharomyces cerevisiae. J Biol Chem. 2003;278:9318-21 pubmed
    ..These results indicate that Gbp2p is involved in modulating telomere length. ..
  3. Meinel D, Burkert Kautzsch C, Kieser A, O Duibhir E, Siebert M, Mayer A, et al. Recruitment of TREX to the transcription machinery by its direct binding to the phospho-CTD of RNA polymerase II. PLoS Genet. 2013;9:e1003914 pubmed publisher
    ..In summary, we provide insight into how the phospho-code of the CTD directs mRNP formation and export through TREX recruitment...
  4. Buchan J, Muhlrad D, Parker R. P bodies promote stress granule assembly in Saccharomyces cerevisiae. J Cell Biol. 2008;183:441-55 pubmed publisher
    ..These observations argue that P bodies are important sites for decisions of mRNA fate and that stress granules, at least in yeast, primarily represent pools of mRNAs stalled in the process of reentry into translation from P bodies. ..
  5. Hackmann A, Wu H, Schneider U, Meyer K, Jung K, Krebber H. Quality control of spliced mRNAs requires the shuttling SR proteins Gbp2 and Hrb1. Nat Commun. 2014;5:3123 pubmed publisher
    ..Here we show that the two shuttling serine/arginine (SR)-proteins Gbp2 and Hrb1 are key surveillance factors for the selective export of spliced mRNAs in yeast...
  6. Martínez Lumbreras S, Taverniti V, Zorrilla S, Séraphin B, Pérez Cañadillas J. Gbp2 interacts with THO/TREX through a novel type of RRM domain. Nucleic Acids Res. 2016;44:437-48 pubmed publisher
    ..We determined the NMR structures and nucleic acid interaction modes of Gbp2 and Hrb1, two paralogous budding yeast proteins with similarities to mammalian SR proteins...
  7. Zander G, Hackmann A, Bender L, Becker D, Lingner T, Salinas G, et al. mRNA quality control is bypassed for immediate export of stress-responsive transcripts. Nature. 2016;: pubmed publisher
    ..In Saccharomyces cerevisiae, the shuttling RNA adaptor proteins Npl3, Gbp2, Hrb1 and Nab2 are loaded co-transcriptionally onto growing pre-mRNAs...
  8. Lin J, Zakian V. Isolation and characterization of two Saccharomyces cerevisiae genes that encode proteins that bind to (TG1-3)n single strand telomeric DNA in vitro. Nucleic Acids Res. 1994;22:4906-13 pubmed
    ..The second gene, GBP2 (G-strand Binding Protein), is an anonymous open reading frame from chromosome III...
  9. Windgassen M, Sturm D, Cajigas I, Gonzalez C, Seedorf M, Bastians H, et al. Yeast shuttling SR proteins Npl3p, Gbp2p, and Hrb1p are part of the translating mRNPs, and Npl3p can function as a translational repressor. Mol Cell Biol. 2004;24:10479-91 pubmed
    ..Together, these data shed light onto the transformation of an exporting to a translating mRNP. ..

More Information

Publications14

  1. Lukasiewicz R, Velazquez Dones A, Huynh N, Hagopian J, Fu X, Adams J, et al. Structurally unique yeast and mammalian serine-arginine protein kinases catalyze evolutionarily conserved phosphorylation reactions. J Biol Chem. 2007;282:23036-43 pubmed
    ..Thus, there are physical attributes of SR and SR-like substrates that dictate the mechanism of phosphorylation, whereas the ability to processively phosphorylate substrates is inherent to SR protein kinases. ..
  2. Gao L, Bretscher A. Analysis of unregulated formin activity reveals how yeast can balance F-actin assembly between different microfilament-based organizations. Mol Biol Cell. 2008;19:1474-84 pubmed publisher
    ..Thus, cells must have a way of ensuring a proper balance between actin assembly pathways. ..
  3. Konkel L, Enomoto S, Chamberlain E, McCune Zierath P, Iyadurai S, Berman J. A class of single-stranded telomeric DNA-binding proteins required for Rap1p localization in yeast nuclei. Proc Natl Acad Sci U S A. 1995;92:5558-62 pubmed
    ..Disruption of RLF6 alters the distribution of repressor/activator protein 1 (Rap1p), a telomere-associated protein...
  4. Inoue K, Mizuno T, Wada K, Hagiwara M. Novel RING finger proteins, Air1p and Air2p, interact with Hmt1p and inhibit the arginine methylation of Npl3p. J Biol Chem. 2000;275:32793-9 pubmed
    ..Thus, Air1p and Air2p may affect mRNA transport by regulating the arginine methylation state of heterogeneous nuclear ribonucleoproteins...
  5. Erce M, Abeygunawardena D, Low J, Hart Smith G, Wilkins M. Interactions affected by arginine methylation in the yeast protein-protein interaction network. Mol Cell Proteomics. 2013;12:3184-98 pubmed publisher
    ..Interactions between the yeast hub protein Npl3 and yeast proteins Air2, Ded1, Gbp2, Snp1, and Yra1 were first validated in the absence of methylation...