FUN30

Summary

Gene Symbol: FUN30
Description: DNA-dependent ATPase FUN30
Alias: DNA-dependent ATPase FUN30
Species: Saccharomyces cerevisiae S288c
Products:     FUN30

Top Publications

  1. Chen X, Cui D, Papusha A, Zhang X, Chu C, Tang J, et al. The Fun30 nucleosome remodeller promotes resection of DNA double-strand break ends. Nature. 2012;489:576-80 pubmed publisher
    ..Here we identify the yeast nucleosome-remodelling enzyme Fun30 as a factor promoting DSB end resection...
  2. Eapen V, Sugawara N, Tsabar M, Wu W, Haber J. The Saccharomyces cerevisiae chromatin remodeler Fun30 regulates DNA end resection and checkpoint deactivation. Mol Cell Biol. 2012;32:4727-40 pubmed publisher
    b>Fun30 is a Swi2/Snf2 homolog in budding yeast that has been shown to remodel chromatin both in vitro and in vivo...
  3. Awad S, Ryan D, Prochasson P, Owen Hughes T, Hassan A. The Snf2 homolog Fun30 acts as a homodimeric ATP-dependent chromatin-remodeling enzyme. J Biol Chem. 2010;285:9477-84 pubmed publisher
    The Saccharomyces cerevisiae Fun30 (Function unknown now 30) protein shares homology with an extended family of Snf2-related ATPases...
  4. Ouspenski I, Elledge S, Brinkley B. New yeast genes important for chromosome integrity and segregation identified by dosage effects on genome stability. Nucleic Acids Res. 1999;27:3001-8 pubmed
    ..We have created deletions of five genes obtained in this screen, CST9, CST13, NAT1, SBA1 and FUN30. None of these genes is essential for viability, and deletions of NAT1 and SBA1 cause chromosome instability, a ..
  5. Yu Q, Zhang X, Bi X. Roles of chromatin remodeling factors in the formation and maintenance of heterochromatin structure. J Biol Chem. 2011;286:14659-69 pubmed publisher
    ..Therefore, chromatin remodeling proteins may rearrange nucleosomes during the formation of heterochromatin or serve to stabilize/maintain heterochromatin structure. ..
  6. Neves Costa A, Will W, Vetter A, Miller J, Varga Weisz P. The SNF2-family member Fun30 promotes gene silencing in heterochromatic loci. PLoS ONE. 2009;4:e8111 pubmed publisher
    ..Even simple eukaryotes such as yeast contain members of several subfamilies of SNF2-like factors. The FUN30/ETL1 subfamily of SNF2 remodellers is conserved from yeasts to humans, but is poorly characterized...
  7. Costelloe T, Louge R, Tomimatsu N, Mukherjee B, Martini E, Khadaroo B, et al. The yeast Fun30 and human SMARCAD1 chromatin remodellers promote DNA end resection. Nature. 2012;489:581-4 pubmed publisher
    ..Here we show that the yeast Saccharomyces cerevisiae Fun30 protein and its human counterpart SMARCAD1 (ref...
  8. Byeon B, Wang W, Barski A, Ranallo R, Bao K, Schones D, et al. The ATP-dependent chromatin remodeling enzyme Fun30 represses transcription by sliding promoter-proximal nucleosomes. J Biol Chem. 2013;288:23182-93 pubmed publisher
    The evolutionarily conserved ATP-dependent chromatin remodeling enzyme Fun30 has recently been shown to play important roles in heterochromatin silencing and DNA repair. However, how Fun30 remodels nucleosomes is not clear...
  9. Chen H, Symington L. Overcoming the chromatin barrier to end resection. Cell Res. 2013;23:317-9 pubmed publisher
    ..Two papers in Nature report that Fun30, a poorly characterized member of the Swi2/Snf2 family of chromatin remodelers, plays a role in end processing by ..

More Information

Publications15

  1. Bantele S, Ferreira P, Gritenaite D, Boos D, Pfander B. Targeting of the Fun30 nucleosome remodeller by the Dpb11 scaffold facilitates cell cycle-regulated DNA end resection. elife. 2017;6: pubmed publisher
    ..Here, we show that both layers of control converge in the regulation of resection by the evolutionarily conserved Fun30/SMARCAD1 remodeller...
  2. Durand Dubief M, Will W, Petrini E, Theodorou D, Harris R, Crawford M, et al. SWI/SNF-like chromatin remodeling factor Fun30 supports point centromere function in S. cerevisiae. PLoS Genet. 2012;8:e1002974 pubmed publisher
    ..Here we show that Fun30, a poorly understood SWI/SNF-like chromatin remodeling factor conserved in humans, promotes point centromere ..
  3. Bi X, Yu Q, Siler J, Li C, Khan A. Functions of Fun30 chromatin remodeler in regulating cellular resistance to genotoxic stress. PLoS ONE. 2015;10:e0121341 pubmed publisher
    The Saccharomyces cerevisiae Fun30 chromatin remodeler has recently been shown to facilitate long-range resection of DNA double strand break (DSB) ends, which proceeds homologous recombination (HR)...
  4. Chen X, Niu H, Yu Y, Wang J, Zhu S, Zhou J, et al. Enrichment of Cdk1-cyclins at DNA double-strand breaks stimulates Fun30 phosphorylation and DNA end resection. Nucleic Acids Res. 2016;44:2742-53 pubmed publisher
    ..Here we identify the Fun30 chromatin remodeler as a new target of Cdk1...
  5. Mehta A, Beach A, Haber J. Homology Requirements and Competition between Gene Conversion and Break-Induced Replication during Double-Strand Break Repair. Mol Cell. 2017;65:515-526.e3 pubmed publisher
    ..With short second-end homology, absence of the RecQ helicase Sgs1 promotes gene conversion, whereas deletion of the FANCM-related Mph1 helicase promotes BIR. ..
  6. Siler J, Xia B, Wong C, Kath M, Bi X. Cell cycle-dependent positive and negative functions of Fun30 chromatin remodeler in DNA damage response. DNA Repair (Amst). 2017;50:61-70 pubmed publisher
    The evolutionally conserved Fun30 chromatin remodeler in Saccharomyces cerevisiae has been shown to contribute to cellular resistance to genotoxic stress inflicted by camptothecin (CPT), methyl methanesulfonate (MMS) and hydroxyurea (HU)...