Gene Symbol: FUM1
Description: fumarase FUM1
Alias: fumarase FUM1
Species: Saccharomyces cerevisiae S288c
Sass E, Blachinsky E, Karniely S, Pines O. Mitochondrial and cytosolic isoforms of yeast fumarase are derivatives of a single translation product and have identical amino termini. J Biol Chem. 2001;276:46111-7 pubmed
We have previously proposed that a single translation product of the FUM1 gene encoding fumarase is distributed between the cytosol and mitochondria of Saccharomyces cerevisiae and that all fumarase translation products are targeted and ..
Singh B, Gupta R. Mitochondrial import of human and yeast fumarase in live mammalian cells: retrograde translocation of the yeast enzyme is mainly caused by its poor targeting sequence. Biochem Biophys Res Commun. 2006;346:911-8 pubmed
Regev Rudzki N, Battat E, Goldberg I, Pines O. Dual localization of fumarase is dependent on the integrity of the glyoxylate shunt. Mol Microbiol. 2009;72:297-306 pubmed
..Specifically, we suggest that metabolites of the glyoxylate shunt act as 'nanosensors' for fumarase subcellular targeting and distribution. The possible mechanisms involved are discussed. ..
Lin A, Anderson S, Minard K, McAlister Henn L. Effects of excess succinate and retrograde control of metabolite accumulation in yeast tricarboxylic cycle mutants. J Biol Chem. 2011;286:33737-46 pubmed publisher
Cellular and mitochondrial metabolite levels were measured in yeast TCA cycle mutants (sdh2? or fum1?) lacking succinate dehydrogenase or fumarase activities...
Wu M, Tzagoloff A. Mitochondrial and cytoplasmic fumarases in Saccharomyces cerevisiae are encoded by a single nuclear gene FUM1. J Biol Chem. 1987;262:12275-82 pubmed
..A representative mutant from this complementation group was used to clone a nuclear gene (FUM1) whose sequence encodes a protein homologous to bacterial fumarase...
Yogev O, Yogev O, Singer E, Shaulian E, Goldberg M, Fox T, et al
. Fumarase: a mitochondrial metabolic enzyme and a cytosolic/nuclear component of the DNA damage response. PLoS Biol. 2010;8:e1000328 pubmed publisher
..This study shows an exciting crosstalk between primary metabolism and the DNA damage response, thereby providing a scenario for metabolic control of tumor propagation. ..
Kaclíková E, Lachowicz T, Gbelska Y, Subik J. Fumaric acid overproduction in yeast mutants deficient in fumarase. FEMS Microbiol Lett. 1992;70:101-6 pubmed
..This accumulation was observed only in growing cultures and required functional mitochondrial electron transport from succinate dehydrogenase to oxygen. ..
Grandier Vazeille X, Bathany K, Chaignepain S, Camougrand N, Manon S, Schmitter J. Yeast mitochondrial dehydrogenases are associated in a supramolecular complex. Biochemistry. 2001;40:9758-69 pubmed
..The association of these proteins is discussed in terms of NADH-channeling. ..
McAlister Henn L, Small W. Molecular genetics of yeast TCA cycle isozymes. Prog Nucleic Acid Res Mol Biol. 1997;57:317-39 pubmed