Gene Symbol: FPR3
Description: peptidylprolyl isomerase FPR3
Alias: NPI46, peptidylprolyl isomerase FPR3
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Hochwagen A, Tham W, Brar G, Amon A. The FK506 binding protein Fpr3 counteracts protein phosphatase 1 to maintain meiotic recombination checkpoint activity. Cell. 2005;122:861-73 pubmed
    ..Here, we show that the FK506 binding protein Fpr3 prevents premature adaptation to damage and thus serves to maintain recombination checkpoint activity...
  2. Benton B, Zang J, Thorner J. A novel FK506- and rapamycin-binding protein (FPR3 gene product) in the yeast Saccharomyces cerevisiae is a proline rotamase localized to the nucleolus. J Cell Biol. 1994;127:623-39 pubmed
    The gene (FPR3) encoding a novel type of peptidylpropyl-cis-trans-isomerase (PPIase) was isolated during a search for previously unidentified nuclear proteins in Saccharomyces cerevisiae...
  3. Valencia Burton M, Oki M, Johnson J, Seier T, Kamakaka R, Haber J. Different mating-type-regulated genes affect the DNA repair defects of Saccharomyces RAD51, RAD52 and RAD55 mutants. Genetics. 2006;174:41-55 pubmed
    ..The rad52-Delta327 mutation is suppressed by deleting the prolyl isomerase Fpr3, which is not MAT regulated...
  4. Li X, Li Y, Arendt C, Hochstrasser M. Distinct Elements in the Proteasomal β5 Subunit Propeptide Required for Autocatalytic Processing and Proteasome Assembly. J Biol Chem. 2016;291:1991-2003 pubmed publisher
    ..Our results suggest that β7 insertion precedes half-mer dimerization, and the β7 tail and β5 propeptide have unequal roles in half-mer joining. ..
  5. Wilson L, Dhillon N, Thorner J, Martin G. Casein kinase II catalyzes tyrosine phosphorylation of the yeast nucleolar immunophilin Fpr3. J Biol Chem. 1997;272:12961-7 pubmed
    In the yeast Saccharomyces cerevisiae, the nucleolar immunophilin, Fpr3, is phosphorylated at tyrosine and dephosphorylated by the phosphotyrosine-specific phosphoprotein phosphatase, Ptp1...
  6. Fath S, Milkereit P, Podtelejnikov A, Bischler N, Schultz P, Bier M, et al. Association of yeast RNA polymerase I with a nucleolar substructure active in rRNA synthesis and processing. J Cell Biol. 2000;149:575-90 pubmed
    ..Our results support the idea that a functional nucleolar subdomain formed independently of the state of rDNA transcription may serve as a scaffold for coordinated rRNA synthesis and processing. ..
  7. Davey M, Hannam C, Wong C, Brandl C. The yeast peptidyl proline isomerases FPR3 and FPR4, in high copy numbers, suppress defects resulting from the absence of the E3 ubiquitin ligase TOM1. Mol Gen Genet. 2000;263:520-6 pubmed
    ..b>FPR3 can also suppress the mating defect seen in tom1 strains...
  8. Sydorskyy Y, Dilworth D, Halloran B, Yi E, Makhnevych T, Wozniak R, et al. Nop53p is a novel nucleolar 60S ribosomal subunit biogenesis protein. Biochem J. 2005;388:819-26 pubmed
  9. Shan X, Xue Z, Melese T. Yeast NPI46 encodes a novel prolyl cis-trans isomerase that is located in the nucleolus. J Cell Biol. 1994;126:853-62 pubmed
    We have identified a gene (NPI46) encoding a new prolyl cis-trans isomerase within the nucleolus of the yeast Saccharomyces cerevisiae...

More Information


  1. MacQueen A, Roeder G. Fpr3 and Zip3 ensure that initiation of meiotic recombination precedes chromosome synapsis in budding yeast. Curr Biol. 2009;19:1519-26 pubmed publisher
    ..We show here that the yeast proline isomerase Fpr3 and the small ubiquitin-like modifier (SUMO) ligase Zip3 ensure that SC assembly is dependent upon recombination ..
  2. Padmanabhan N, Fichtner L, Dickmanns A, Ficner R, Schulz J, Braus G. The yeast HtrA orthologue Ynm3 is a protease with chaperone activity that aids survival under heat stress. Mol Biol Cell. 2009;20:68-77 pubmed publisher
    ..Suppression studies with Deltaynm3 led to the discovery of chaperone activity in a nucleolar peptidyl-prolyl cis-trans isomerase, Fpr3, which could partly relieve the heat sensitivity of Deltaynm3.
  3. Utsugi T, Hirata A, Sekiguchi Y, Sasaki T, Toh e A, Kikuchi Y. Yeast tom1 mutant exhibits pleiotropic defects in nuclear division, maintenance of nuclear structure and nucleocytoplasmic transport at high temperatures. Gene. 1999;234:285-95 pubmed
    ..Taken together, we suggest that Tom1 is a ubiquitin ligase. As a multi-copy suppressor of tom1, we isolated STM3/NPI46/FPR3 which encodes a nucleolar nucleolin-like protein...
  4. Wilson L, Benton B, Zhou S, Thorner J, Martin G. The yeast immunophilin Fpr3 is a physiological substrate of the tyrosine-specific phosphoprotein phosphatase Ptp1. J Biol Chem. 1995;270:25185-93 pubmed
    ..purified to homogeneity; analysis of four tryptic peptides revealed that p70 is identical to the recently described FPR3 gene product, a nucleolarly localized proline rotamase of the FK506- and rapamycin-binding family...
  5. Wohlschlegel J, Johnson E, Reed S, Yates J. Global analysis of protein sumoylation in Saccharomyces cerevisiae. J Biol Chem. 2004;279:45662-8 pubmed
    ..Additionally, our global analysis has revealed a number of interesting biological patterns in the list of SUMO targets including a clustering of sumoylation targets within macromolecular complexes. ..
  6. Park S, Xiao H, Lei M. Nuclear FKBPs, Fpr3 and Fpr4 affect genome-wide genes transcription. Mol Genet Genomics. 2014;289:125-36 pubmed publisher
    b>Fpr3 and Fpr4 of Saccharomyces cerevisiae are nuclear FK506-binding proteins each containing an extended acidic domain in addition to the conserved FK506-binding/peptidylprolyl isomerase (PPIase) domain...
  7. Copsey A, Tang S, Jordan P, Blitzblau H, Newcombe S, Chan A, et al. Smc5/6 coordinates formation and resolution of joint molecules with chromosome morphology to ensure meiotic divisions. PLoS Genet. 2013;9:e1004071 pubmed publisher
  8. Magherini F, Gamberi T, Paoli P, Marchetta M, Biagini M, Raugei G, et al. The in vivo tyrosine phosphorylation level of yeast immunophilin Fpr3 is influenced by the LMW-PTP Ltp1. Biochem Biophys Res Commun. 2004;321:424-31 pubmed
    ..Recently we showed that the yeast immunophilin Fpr3 interacts with Stp1 and its dephosphorylated state induces a growth defective phenotype...
  9. Iacovella M, Daly C, Kelly J, Michielsen A, Clyne R. Analysis of Polo-like kinase Cdc5 in the meiosis recombination checkpoint. Cell Cycle. 2010;9:1182-93 pubmed
    ..The cdc5-ad mutation that renders cells unable to adapt to DNA damage in mitosis did not affect checkpoint adaptation in meiosis, indicating that the mechanisms of checkpoint adaptation in mitosis and meiosis are not fully conserved. ..
  10. Ohkuni K, Abdulle R, Kitagawa K. Degradation of centromeric histone H3 variant Cse4 requires the Fpr3 peptidyl-prolyl Cis-Trans isomerase. Genetics. 2014;196:1041-5 pubmed publisher
    ..We report here that the proline isomerase Fpr3 regulates Cse4 proteolysis...
  11. Denison C, Rudner A, Gerber S, Bakalarski C, Moazed D, Gygi S. A proteomic strategy for gaining insights into protein sumoylation in yeast. Mol Cell Proteomics. 2005;4:246-54 pubmed
    ..These data combine with recent works to further our understanding of the breadth and impact of protein sumoylation in a diverse array of biological processes. ..
  12. Manning Krieg U, Henriquez R, Cammas F, Graff P, Gaveriaux S, Movva N. Purification of FKBP-70, a novel immunophilin from Saccharomyces cerevisiae, and cloning of its structural gene, FPR3. FEBS Lett. 1994;352:98-103 pubmed
    ..Its structural gene, FPR3, was cloned and the protein expressed and purified from Escherichia coli...