FMT1

Summary

Gene Symbol: FMT1
Description: methionyl-tRNA formyltransferase
Alias: methionyl-tRNA formyltransferase
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Li Y, Holmes W, Appling D, RajBhandary U. Initiation of protein synthesis in Saccharomyces cerevisiae mitochondria without formylation of the initiator tRNA. J Bacteriol. 2000;182:2886-92 pubmed
    ..for synthesis of 10-formyl-THF, and the methionyl-tRNA formyltransferase (open reading frame YBL013W; designated FMT1)...
  2. Vial L, Gomez P, Panvert M, Schmitt E, Blanquet S, Mechulam Y. Mitochondrial methionyl-tRNAfMet formyltransferase from Saccharomyces cerevisiae: gene disruption and tRNA substrate specificity. Biochemistry. 2003;42:932-9 pubmed
    ..Each mechanism appears well suited to an efficient selection of the substrate within the pool of all tRNAs. ..
  3. Halbreich A, Rabinowitz M. Isolation of Saccharomyces cerevisiae mitochondrial formyltetrahydrofolic acid:methionyl-tRNA transformylase and the hybridization of mitochondrial fMet-tRNA with mitochondrial DNA. Proc Natl Acad Sci U S A. 1971;68:294-8 pubmed
    ..Yeast cytoplasmic fMet-tRNA formylated with Escherichia coli enzyme, and E. coli fMet-tRNA, do not hybridize with mitochondrial DNA. It is concluded that yeast mitochondrial tRNA(fMet) is a gene product of the mitochondrial genome. ..
  4. Lee C, Tibbetts A, Kramer G, Appling D. Yeast AEP3p is an accessory factor in initiation of mitochondrial translation. J Biol Chem. 2009;284:34116-25 pubmed publisher
    ..as demonstrated in yeast mutants in which the nuclear gene encoding mitochondrial methionyl-tRNA formyltransferase (FMT1) has been deleted...
  5. Williams E, Butler C, Bonnefoy N, Fox T. Translation initiation in Saccharomyces cerevisiae mitochondria: functional interactions among mitochondrial ribosomal protein Rsm28p, initiation factor 2, methionyl-tRNA-formyltransferase and novel protein Rmd9p. Genetics. 2007;175:1117-26 pubmed
    ..identified three nuclear genes: IFM1, which encodes the mitochondrial translation initiation factor 2 (IF2); FMT1, which encodes the methionyl-tRNA-formyltransferase; and RMD9, a gene of unknown function...