Gene Symbol: FMO1
Description: N,N-dimethylaniline monooxygenase
Alias: N,N-dimethylaniline monooxygenase
Species: Saccharomyces cerevisiae S288c
- Suh J, Poulsen L, Ziegler D, Robertus J. Lysine 219 participates in NADPH specificity in a flavin-containing monooxygenase from Saccharomyces cerevisiae. Arch Biochem Biophys. 1999;372:360-6 pubmed..Dissociation constants for NADP(+) to oxidized yFMO were measured spectroscopically. K(d) is 12 microM for the wild-type enzyme and 243 microM for the K219A mutant, consistent with the role of Lys 219 in pyridine nucleotide binding. ..
- Suh J, Poulsen L, Ziegler D, Robertus J. Yeast flavin-containing monooxygenase generates oxidizing equivalents that control protein folding in the endoplasmic reticulum. Proc Natl Acad Sci U S A. 1999;96:2687-91 pubmed..The enzyme is required for the proper folding, in the ER, of test proteins with disulfide bonds, whereas those without disulfide bonds are properly folded independently of yFMO in the ER or in the cytoplasm. ..
- Bartsch M, Gobbato E, Bednarek P, Debey S, Schultze J, Bautor J, et al. Salicylic acid-independent ENHANCED DISEASE SUSCEPTIBILITY1 signaling in Arabidopsis immunity and cell death is regulated by the monooxygenase FMO1 and the Nudix hydrolase NUDT7. Plant Cell. 2006;18:1038-51 pubmed..FLAVIN-DEPENDENT MONOOXYGENASE1 (FMO1) positively regulates the EDS1 pathway, and one member (NUDT7) of a family of cytosolic Nudix hydrolases exerts ..