Gene Symbol: FHL1
Description: Fhl1p
Alias: SPP42, Fhl1p
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Maddock J, Weidenhammer E, Adams C, Lunz R, Woolford J. Extragenic suppressors of Saccharomyces cerevisiae prp4 mutations identify a negative regulator of PRP genes. Genetics. 1994;136:833-47 pubmed
    ..Ten independent recessive suppressors were obtained that identified four complementation groups, spp41, spp42, spp43 and spp44 (suppressor of prp4, numbers 1-4)...
  2. Tai A, Kamei Y, Mukai Y. The forkhead-like transcription factor (Fhl1p) maintains yeast replicative lifespan by regulating ribonucleotide reductase 1 (RNR1) gene transcription. Biochem Biophys Res Commun. 2017;488:218-223 pubmed publisher
    ..To determine how Fhl1p regulates the lifespan, we performed a DNA microarray analysis of a heterozygous diploid strain deleted for FHL1...
  3. Downey M, Knight B, Vashisht A, Seller C, Wohlschlegel J, Shore D, et al. Gcn5 and sirtuins regulate acetylation of the ribosomal protein transcription factor Ifh1. Curr Biol. 2013;23:1638-48 pubmed publisher
    ..We provide insights into how the action of histone acetylation machineries converges with nutrient-sensing pathways to regulate important aspects of cell growth. ..
  4. Daniel J. Direct in vivo access to potential gene targets of the RPD3 histone deactylase using fitness-based interferential genetics. Yeast. 2007;24:575-87 pubmed
    ..studies using different methods, three genes were found to be involved in the translational machinery (MRPL27, FHL1 and RDN1). Moreover, other selected genes are linked to cell-cycle control (CSE4, AMN1, VAC17 and GRR1)...
  5. Rudra D, Zhao Y, Warner J. Central role of Ifh1p-Fhl1p interaction in the synthesis of yeast ribosomal proteins. EMBO J. 2005;24:533-42 pubmed
    ..The basis for this observation remains unknown. We now provide evidence that two factors, Fhl1p and Ifh1p, are key players in the transcription of RP genes. Both are found at transcribing RP genes in vivo...
  6. Schawalder S, Kabani M, Howald I, Choudhury U, Werner M, Shore D. Growth-regulated recruitment of the essential yeast ribosomal protein gene activator Ifh1. Nature. 2004;432:1058-61 pubmed
    ..Rap1 (refs 6, 7) and more recently Fhl1 (ref. 8) were shown to bind upstream of many RP genes...
  7. Hermann Le Denmat S, Werner M, Sentenac A, Thuriaux P. Suppression of yeast RNA polymerase III mutations by FHL1, a gene coding for a fork head protein involved in rRNA processing. Mol Cell Biol. 1994;14:2905-13 pubmed
    ..There was no detectable effect on mRNA splicing. Thus, the Fhl1p protein plays a key role in the control of rRNA processing, presumably by acting as a transcriptional regulator of ..
  8. Jorgensen P, Rupes I, Sharom J, Schneper L, Broach J, Tyers M. A dynamic transcriptional network communicates growth potential to ribosome synthesis and critical cell size. Genes Dev. 2004;18:2491-505 pubmed
    ..In turn, Sfp1 influences the nuclear localization of Fhl1 and Ifh1, which bind to RP gene promoters...
  9. Kleinschmidt M, Schulz R, Braus G. The yeast CPC2/ASC1 gene is regulated by the transcription factors Fhl1p and Ifh1p. Curr Genet. 2006;49:218-28 pubmed
    ..motif, which has previously been described as a putative binding site for the forkhead-like transcription factor Fhl1p. Deletion of FHL1 reduces CPC2 transcription significantly in presence of glucose, but has no effect when the non-..

More Information


  1. Rudra D, Mallick J, Zhao Y, Warner J. Potential interface between ribosomal protein production and pre-rRNA processing. Mol Cell Biol. 2007;27:4815-24 pubmed
    ..total transcription by RNA polymerase II, is controlled by the interaction of three transcription factors, Rap1, Fhl1, and Ifh1. Of these, only Rap1 binds directly to DNA and only Ifh1 is absent when transcription is repressed...
  2. Lefebvre O, Ruth J, Sentenac A. A mutation in the largest subunit of yeast TFIIIC affects tRNA and 5 S RNA synthesis. Identification of two classes of suppressors. J Biol Chem. 1994;269:23374-81 pubmed
    ..A second class of suppressors is not involved in transcription but alleviates the main physiological defects of mutant cells. It includes RPR1 and NOP1, required for the maturation of pre-tRNA and pre-rRNA, respectively. ..
  3. Kamei Y, Tai A, Dakeyama S, Yamamoto K, Inoue Y, Kishimoto Y, et al. Transcription factor genes essential for cell proliferation and replicative lifespan in budding yeast. Biochem Biophys Res Commun. 2015;463:351-6 pubmed publisher
    ..Heterozygous diploid knockout strains for FHL1, RAP1, REB1, and MCM1 genes showed significantly short lifespan...
  4. Fermi B, Bosio M, Dieci G. Promoter architecture and transcriptional regulation of Abf1-dependent ribosomal protein genes in Saccharomyces cerevisiae. Nucleic Acids Res. 2016;44:6113-26 pubmed publisher
    ..common promoter architecture, with an Abf1 site upstream of a conserved element matching the sequence recognized by Fhl1, a transcription factor which together with Ifh1 orchestrates Rap1-associated RPG regulation...
  5. Cherel I, Thuriaux P. The IFH1 gene product interacts with a fork head protein in Saccharomyces cerevisiae. Yeast. 1995;11:261-70 pubmed
    ..Conversely, its overexpression by increased gene dosage partially compensates for the genetic inactivation of Fhl1p. These data suggest a direct interaction between the Fhl1p and Ifh1p proteins, and are consistent with a model ..
  6. Martin D, Soulard A, Hall M. TOR regulates ribosomal protein gene expression via PKA and the Forkhead transcription factor FHL1. Cell. 2004;119:969-79 pubmed
    ..that regulation of RP gene transcription via TOR and PKA in yeast involves the Forkhead-like transcription factor FHL1 and the two cofactors IFH1 (a coactivator) and CRF1 (a corepressor)...
  7. Xiao L, Kamau E, Donze D, Grove A. Expression of yeast high mobility group protein HMO1 is regulated by TOR signaling. Gene. 2011;489:55-62 pubmed publisher
    ..The Saccharomyces cerevisiae Forkhead-like transcription factor Fhl1 is important for this regulation, and its localization to ribosomal protein gene promoters requires the high ..
  8. Kim M, Hahn J. Role of CK2-dependent phosphorylation of Ifh1 and Crf1 in transcriptional regulation of ribosomal protein genes in Saccharomyces cerevisiae. Biochim Biophys Acta. 2016;1859:1004-13 pubmed publisher
    In Saccharomyces cerevisiae, Fhl1 is involved in the regulation of ribosomal protein (RP) genes through interaction with either its coactivator Ifh1 or corepressor Crf1, depending on nutrient conditions...