Genomes and Genes
Gene Symbol: FBP1
Description: fructose 1,6-bisphosphate 1-phosphatase
Alias: ACN8, fructose 1,6-bisphosphate 1-phosphatase
Species: Saccharomyces cerevisiae S288c
- Chen S, Wu X, Wadas B, Oh J, Varshavsky A. An N-end rule pathway that recognizes proline and destroys gluconeogenic enzymes. Science. 2017;355: pubmed publisher..Gid4 subunit of the ubiquitin ligase GID in the yeast Saccharomyces cerevisiae targeted the gluconeogenic enzymes Fbp1, Icl1, and Mdh2 for degradation...
- Braun B, Pfirrmann T, Menssen R, Hofmann K, Scheel H, Wolf D. Gid9, a second RING finger protein contributes to the ubiquitin ligase activity of the Gid complex required for catabolite degradation. FEBS Lett. 2011;585:3856-61 pubmed publisher..This subunit binds to Gid2/Rmd5. A mutation in the degenerated RING finger of Gid9/Fyv10 abolishes polyubiquitylation and degradation of three enzymes specific for gluconeogenesis. ..
- Juretschke J, Menssen R, Sickmann A, Wolf D. The Hsp70 chaperone Ssa1 is essential for catabolite induced degradation of the gluconeogenic enzyme fructose-1,6-bisphosphatase. Biochem Biophys Res Commun. 2010;397:447-52 pubmed publisher..Moreover, we show that degradation of an additional gluconeogenic enzyme, phosphoenolpyruvate carboxykinase, is also affected in ssa1-45(ts) cells demonstrating that Ssa1 plays a general role in elimination of gluconeogenic enzymes. ..
- Barbin L, Eisele F, Santt O, Wolf D. The Cdc48-Ufd1-Npl4 complex is central in ubiquitin-proteasome triggered catabolite degradation of fructose-1,6-bisphosphatase. Biochem Biophys Res Commun. 2010;394:335-41 pubmed publisher..We show that this machinery acts between polyubiquitination of FBPase and its degradation by the proteasome. ..
- Gibson N, McAlister Henn L. Physical and genetic interactions of cytosolic malate dehydrogenase with other gluconeogenic enzymes. J Biol Chem. 2003;278:25628-36 pubmed..between MDH2 and yeast phosphoenolpyruvate carboxykinase (PCK1) and between MDH2 and fructose-1,6-bisphosphatase (FBP1)...
- Schule T, Rose M, Entian K, Thumm M, Wolf D. Ubc8p functions in catabolite degradation of fructose-1, 6-bisphosphatase in yeast. EMBO J. 2000;19:2161-7 pubmed..Like FBPase, Ubc8p is found in the cytoplasmic fraction of the cell. We demonstrate cytoplasmic degradation of FBPase. ..
- Gancedo C, Delgado M. Isolation and characterization of a mutant from Saccharomyces cerevisiae lacking fructose 1,6-bisphosphatase. Eur J Biochem. 1984;139:651-5 pubmed..All the mutants isolated were of nuclear origin and defined three complementation groups. ..
- Gancedo J, Mazon M, Gancedo C. Fructose 2,6-bisphosphate activates the cAMP-dependent phosphorylation of yeast fructose-1,6-bisphosphatase in vitro. J Biol Chem. 1983;258:5998-9 pubmed..The characteristics of the phosphorylation reaction in vitro show that this modification is responsible for the inactivation of fructose-1,6-bisphosphatase observed in vivo. ..
- Platta H, Grunau S, Rosenkranz K, Girzalsky W, Erdmann R. Functional role of the AAA peroxins in dislocation of the cycling PTS1 receptor back to the cytosol. Nat Cell Biol. 2005;7:817-22 pubmed..Here we demonstrate that the AAA peroxins mediate the ATP-dependent dislocation of the peroxisomal targeting signal-1 (PTS1) receptor from the peroxisomal membrane to the cytosol. ..
- Alibhoy A, Giardina B, Dunton D, Chiang H. Vps34p is required for the decline of extracellular fructose-1,6-bisphosphatase in the vacuole import and degradation pathway. J Biol Chem. 2012;287:33080-93 pubmed..We suggest that VPS34 plays a critical role in the decline of extracellular FBPase in response to glucose. ..
- Entian K, Vogel R, Rose M, Hofmann L, Mecke D. Isolation and primary structure of the gene encoding fructose-1,6-bisphosphatase from Saccharomyces cerevisiae. FEBS Lett. 1988;236:195-200 pubmedThe gene encoding Saccharomyces cerevisiae fructose-1,6-bisphosphatase (FBP1) was isolated. Constructed fbp1::HIS3 null mutants were unable to grow with ethanol, and growth was restored after transformation with the cloned fbp gene...
- Haarasilta S, Taskinen L. Location of three key enzymes of gluconeogenesis in baker's yeast. Arch Microbiol. 1977;113:159-61 pubmed..On the evidence obtained from zonal separations these three enzymes of gluconeogenesis are most probably located in the soluble cytosol...