Gene Symbol: FBP1
Description: fructose 1,6-bisphosphate 1-phosphatase
Alias: ACN8, fructose 1,6-bisphosphate 1-phosphatase
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Cui D, Brown C, Chiang H. The type 1 phosphatase Reg1p-Glc7p is required for the glucose-induced degradation of fructose-1,6-bisphosphatase in the vacuole. J Biol Chem. 2004;279:9713-24 pubmed
    ..Taken together, our results suggest that Reg1p-Glc7p interaction and Glc7p phosphatase activity play a required role in the Vid vesicle to vacuole-trafficking step along the FBPase degradation pathway. ..
  2. Hung G, Brown C, Wolfe A, Liu J, Chiang H. Degradation of the gluconeogenic enzymes fructose-1,6-bisphosphatase and malate dehydrogenase is mediated by distinct proteolytic pathways and signaling events. J Biol Chem. 2004;279:49138-50 pubmed
    ..By contrast, the cAMP-dependent signaling pathway was not involved in the non-vacuolar degradation of these proteins, although the phosphorylation of glucose was required. ..
  3. Santt O, Pfirrmann T, Braun B, Juretschke J, Kimmig P, Scheel H, et al. The yeast GID complex, a novel ubiquitin ligase (E3) involved in the regulation of carbohydrate metabolism. Mol Biol Cell. 2008;19:3323-33 pubmed publisher
    ..Our study uncovers a new type of ubiquitin ligase complex composed of novel subunits involved in carbohydrate metabolism and identifies Gid4/Vid24 as a major regulator of this E3. ..
  4. Regelmann J, Schüle T, Josupeit F, Horak J, Rose M, Entian K, et al. Catabolite degradation of fructose-1,6-bisphosphatase in the yeast Saccharomyces cerevisiae: a genome-wide screen identifies eight novel GID genes and indicates the existence of two degradation pathways. Mol Biol Cell. 2003;14:1652-63 pubmed
    ..The influence of Ubp14p, a deubiquitinating enzyme, on proteasome-dependent catabolite degradation was further uncovered. ..
  5. Morawiec E, Wichtowska D, Graczyk D, Conesa C, Lefebvre O, Boguta M. Maf1, repressor of tRNA transcription, is involved in the control of gluconeogenetic genes in Saccharomyces cerevisiae. Gene. 2013;526:16-22 pubmed publisher
    ..We found that transcription of FBP1 and PCK1, two major genes controlling gluconeogenesis, was decreased in maf1? cells...
  6. Yan Y, Kang B. Regulation of Vid-dependent degradation of FBPase by TCO89, a component of TOR Complex 1. Int J Biol Sci. 2010;6:361-70 pubmed
    ..The P1S mutation of FBPase, reported to block its degradation, was observed to impair the association of FBPase with TORCI components. These results implicated an important regulatory role of TCO89 and TORCI in this pathway. ..
  7. Brown C, Hung G, Dunton D, Chiang H. The TOR complex 1 is distributed in endosomes and in retrograde vesicles that form from the vacuole membrane and plays an important role in the vacuole import and degradation pathway. J Biol Chem. 2010;285:23359-70 pubmed publisher
    ..We suggest that TORC1 interacts with multiple cargo proteins destined for the Vid pathway and plays an important role in the degradation of FBPase in the vacuole. ..
  8. Kitanovic A, Wolfl S. Fructose-1,6-bisphosphatase mediates cellular responses to DNA damage and aging in Saccharomyces cerevisiae. Mutat Res. 2006;594:135-47 pubmed
    ..RT-PCR analysis showed that the expression of the key enzyme in gluconeogenesis fructose-1,6-bisphosphatase (FBP1) was clearly up-regulated by MMS in glucose-rich medium...
  9. Girzalsky W, Hoffmann L, Schemenewitz A, Nolte A, Kunau W, Erdmann R. Pex19p-dependent targeting of Pex17p, a peripheral component of the peroxisomal protein import machinery. J Biol Chem. 2006;281:19417-25 pubmed

More Information


  1. Chen S, Wu X, Wadas B, Oh J, Varshavsky A. An N-end rule pathway that recognizes proline and destroys gluconeogenic enzymes. Science. 2017;355: pubmed publisher
    ..Gid4 subunit of the ubiquitin ligase GID in the yeast Saccharomyces cerevisiae targeted the gluconeogenic enzymes Fbp1, Icl1, and Mdh2 for degradation...
  2. Braun B, Pfirrmann T, Menssen R, Hofmann K, Scheel H, Wolf D. Gid9, a second RING finger protein contributes to the ubiquitin ligase activity of the Gid complex required for catabolite degradation. FEBS Lett. 2011;585:3856-61 pubmed publisher
    ..This subunit binds to Gid2/Rmd5. A mutation in the degenerated RING finger of Gid9/Fyv10 abolishes polyubiquitylation and degradation of three enzymes specific for gluconeogenesis. ..
  3. Juretschke J, Menssen R, Sickmann A, Wolf D. The Hsp70 chaperone Ssa1 is essential for catabolite induced degradation of the gluconeogenic enzyme fructose-1,6-bisphosphatase. Biochem Biophys Res Commun. 2010;397:447-52 pubmed publisher
    ..Moreover, we show that degradation of an additional gluconeogenic enzyme, phosphoenolpyruvate carboxykinase, is also affected in ssa1-45(ts) cells demonstrating that Ssa1 plays a general role in elimination of gluconeogenic enzymes. ..
  4. Barbin L, Eisele F, Santt O, Wolf D. The Cdc48-Ufd1-Npl4 complex is central in ubiquitin-proteasome triggered catabolite degradation of fructose-1,6-bisphosphatase. Biochem Biophys Res Commun. 2010;394:335-41 pubmed publisher
    ..We show that this machinery acts between polyubiquitination of FBPase and its degradation by the proteasome. ..
  5. Gibson N, McAlister Henn L. Physical and genetic interactions of cytosolic malate dehydrogenase with other gluconeogenic enzymes. J Biol Chem. 2003;278:25628-36 pubmed
    ..between MDH2 and yeast phosphoenolpyruvate carboxykinase (PCK1) and between MDH2 and fructose-1,6-bisphosphatase (FBP1)...
  6. Schule T, Rose M, Entian K, Thumm M, Wolf D. Ubc8p functions in catabolite degradation of fructose-1, 6-bisphosphatase in yeast. EMBO J. 2000;19:2161-7 pubmed
    ..Like FBPase, Ubc8p is found in the cytoplasmic fraction of the cell. We demonstrate cytoplasmic degradation of FBPase. ..
  7. Gancedo C, Delgado M. Isolation and characterization of a mutant from Saccharomyces cerevisiae lacking fructose 1,6-bisphosphatase. Eur J Biochem. 1984;139:651-5 pubmed
    ..All the mutants isolated were of nuclear origin and defined three complementation groups. ..
  8. Gancedo J, Mazon M, Gancedo C. Fructose 2,6-bisphosphate activates the cAMP-dependent phosphorylation of yeast fructose-1,6-bisphosphatase in vitro. J Biol Chem. 1983;258:5998-9 pubmed
    ..The characteristics of the phosphorylation reaction in vitro show that this modification is responsible for the inactivation of fructose-1,6-bisphosphatase observed in vivo. ..
  9. Platta H, Grunau S, Rosenkranz K, Girzalsky W, Erdmann R. Functional role of the AAA peroxins in dislocation of the cycling PTS1 receptor back to the cytosol. Nat Cell Biol. 2005;7:817-22 pubmed
    ..Here we demonstrate that the AAA peroxins mediate the ATP-dependent dislocation of the peroxisomal targeting signal-1 (PTS1) receptor from the peroxisomal membrane to the cytosol. ..
  10. Alibhoy A, Giardina B, Dunton D, Chiang H. Vps34p is required for the decline of extracellular fructose-1,6-bisphosphatase in the vacuole import and degradation pathway. J Biol Chem. 2012;287:33080-93 pubmed
    ..We suggest that VPS34 plays a critical role in the decline of extracellular FBPase in response to glucose. ..
  11. Entian K, Vogel R, Rose M, Hofmann L, Mecke D. Isolation and primary structure of the gene encoding fructose-1,6-bisphosphatase from Saccharomyces cerevisiae. FEBS Lett. 1988;236:195-200 pubmed
    The gene encoding Saccharomyces cerevisiae fructose-1,6-bisphosphatase (FBP1) was isolated. Constructed fbp1::HIS3 null mutants were unable to grow with ethanol, and growth was restored after transformation with the cloned fbp gene...
  12. Haarasilta S, Taskinen L. Location of three key enzymes of gluconeogenesis in baker's yeast. Arch Microbiol. 1977;113:159-61 pubmed
    ..On the evidence obtained from zonal separations these three enzymes of gluconeogenesis are most probably located in the soluble cytosol...