ECM11

Summary

Gene Symbol: ECM11
Description: Ecm11p
Alias: Ecm11p
Species: Saccharomyces cerevisiae S288c

Top Publications

  1. Lussier M, White A, Sheraton J, Di Paolo T, Treadwell J, Southard S, et al. Large scale identification of genes involved in cell surface biosynthesis and architecture in Saccharomyces cerevisiae. Genetics. 1997;147:435-50 pubmed
    ..Fifty of these genes were previously known, 17 encoded proteins whose function could be anticipated through sequence homology or previously recognized phenotypes and 15 genes had no previously known phenotype. ..
  2. Zavec A, Lesnik U, Komel R, Comino A. The Saccharomyces cerevisiae gene ECM11 is a positive effector of meiosis. FEMS Microbiol Lett. 2004;241:193-9 pubmed
    b>Ecm11 is classified as a protein involved in yeast cell wall biogenesis and organization, but in this paper, we provide evidence that it is involved in meiosis as well...
  3. Zavec A, Comino A, Lenassi M, Komel R. Ecm11 protein of yeast Saccharomyces cerevisiae is regulated by sumoylation during meiosis. FEMS Yeast Res. 2008;8:64-70 pubmed
    ..In this study, it is shown that Ecm11 protein in Saccharomyces cerevisiae is modified by SUMO during meiosis...
  4. Humphryes N, Leung W, Argunhan B, Terentyev Y, Dvorácková M, Tsubouchi H. The Ecm11-Gmc2 complex promotes synaptonemal complex formation through assembly of transverse filaments in budding yeast. PLoS Genet. 2013;9:e1003194 pubmed publisher
    ..Here, we show that the Ecm11-Gmc2 complex is a novel SC component, functioning to facilitate assembly of the yeast transverse filament protein, ..
  5. Zavec P, Comino A, Watt P, Komel R. Interaction trap experiment with CDC6. Pflugers Arch. 2000;439:R94-6 pubmed
    ..Four gene products interacting with Cdc6 were detected. By sequence analysis we found that ECM11 codes for the protein involved in the cell wall synthesis, YNL201 codes for the protein of unknown function, ..
  6. Comino A, Mancek M, Komel R. Ecm11 is located in the cell nucleus throughout mitosis. Pflugers Arch. 2001;442:R179-81 pubmed
    It was found previously that Ecm11 interacts with Cdc6 in a two-hybrid screen. To verify that these two gene products can actually encounter in the living cell, ECM11 was expressed as a fusion with GFP...
  7. Zavec P, Comino A, Watt P, Komel R. Interaction trap experiment with CDC6. Pflugers Arch. 2000;439:r094-r096 pubmed publisher
    ..Four gene products interacting with Cdc6 were detected. By sequence analysis we found that ECM11 codes for the protein involved in the cell wall synthesis, YNL201 codes for the protein of unknown function, ..
  8. Voelkel Meiman K, Taylor L, Mukherjee P, Humphryes N, Tsubouchi H, MacQueen A. SUMO localizes to the central element of synaptonemal complex and is required for the full synapsis of meiotic chromosomes in budding yeast. PLoS Genet. 2013;9:e1003837 pubmed publisher
    ..The recently identified SUMOylated SC component, Ecm11, also localizes to the SC central element...
  9. Voelkel Meiman K, Cheng S, Morehouse S, MacQueen A. Synaptonemal Complex Proteins of Budding Yeast Define Reciprocal Roles in MutS?-Mediated Crossover Formation. Genetics. 2016;203:1091-103 pubmed publisher
    ..in MutS?-mediated crossovers during meiosis-in budding yeast mutants devoid of the SC central element components Ecm11 or Gmc2, and in mutants expressing a version of Zip1 missing most of its N terminus...

More Information

Publications12

  1. Herruzo E, Ontoso D, González Arranz S, Cavero S, Lechuga A, San Segundo P. The Pch2 AAA+ ATPase promotes phosphorylation of the Hop1 meiotic checkpoint adaptor in response to synaptonemal complex defects. Nucleic Acids Res. 2016;44:7722-41 pubmed publisher
    ..Based on our results, we propose that, under checkpoint-inducing conditions, Pch2 also possesses a positive action on Hop1 promoting its phosphorylation and its proper distribution on unsynapsed chromosome axes. ..
  2. Muñoz Galvan S, Jimeno S, Rothstein R, Aguilera A. Histone H3K56 acetylation, Rad52, and non-DNA repair factors control double-strand break repair choice with the sister chromatid. PLoS Genet. 2013;9:e1003237 pubmed publisher
    ..A dysfunction can lead to genome instability as manifested by high levels of homolog recombination and DSB accumulation...
  3. Kurdzo E, Obeso D, Chuong H, Dawson D. Meiotic Centromere Coupling and Pairing Function by Two Separate Mechanisms in Saccharomyces cerevisiae. Genetics. 2017;205:657-671 pubmed publisher
    ..In addition, we tested other synaptonemal complex components, Ecm11 and Zip4, for their contributions to centromere pairing...